Thermopsis spp.
Species
KNApSAcK Entry
| Organism name | Thermopsis spp. |
|---|---|
| Genus | Thermopsis |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Thermopsis |
|---|---|
| Linked NCBI taxonomy ID | 49852 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (9)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00010119
|
Oroboside
/ Orobol 7-O-glucoside |
No. 2 | No. 15 |
|
||||
|
C00002553
|
Ononin
/ Formononetin 7-O-glucoside |
CHEMBL465980
|
11 / 14 / 40 | No. 2 | No. 15 |
|
||
|
C00010087
|
Calycosin 7-O-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00010122
|
Pratensein 7-O-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00002563
|
Pratensein
/ 5,7,3'-Trihydroxy-4'-methoxyisoflavone |
CHEMBL252904
|
No. 3 | No. 15 |
|
|||
|
C00009458
|
3'-Methylorobol
/ 3'-O-Methylorobol / Orobol 3'-methyl ether |
CHEMBL241402
|
No. 3 | No. 15 |
|
|||
|
C00002554
|
Orobol
/ Santol / Norsantal / 5,7,3',4'-Tetrahydroxyisoflavone |
CHEMBL241609
|
C059811
|
1 / 1 / 8 | No. 71 | No. 15 |
|
|
|
C00002218
|
Cytisine
/ (-)-Cytisine |
CHEMBL47039
CHEMBL497939 CHEMBL1628606 |
C004712
|
27 / 36 / 33 | 6 / 1 | No. 376 | No. 3 |
|
|
C00010186
|
Trifolirhizin
/ Sophojaponicin B1 / (-)-Maackiain 3-O-glucoside |
CHEMBL454878
|
No. 557 | No. 15 |
|
Human Protein / Gene in interactions
39 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002218 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002553 | 7 / 37 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002218 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002218 | 6 / 4 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002218 | 11 / 10 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002553 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002218 | 0 / 1 |
| P30926 | Neuronal acetylcholine receptor subunit beta-4 | CHRN beta | C00002218 | 0 / 0 |
| P32297 | Neuronal acetylcholine receptor subunit alpha-3 | CHRN alpha | C00002218 | 1 / 0 |
| Q07001 | Acetylcholine receptor subunit delta | CHRN delta | C00002218 | 3 / 2 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00002218 | 1 / 1 |
| P07510 | Acetylcholine receptor subunit gamma | CHRN gamma | C00002218 | 2 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00002218 | 1 / 1 |
| P02708 | Acetylcholine receptor subunit alpha | CHRN alpha | C00002218 | 3 / 2 |
| P11230 | Acetylcholine receptor subunit beta | CHRN beta | C00002218 | 2 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002554 | 1 / 8 |
| O75496 | Geminin | Unclassified protein | C00002218 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002553 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002553 | 4 / 2 |
| P15121 | Aldose reductase | Enzyme | C00002553 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002218 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002218 | 0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00002218 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002218 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002553 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002553 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002218 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002218 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002553 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002218 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002553 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002218 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00002218 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002218 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002218 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002218 | 1 / 4 |
| Q15822 | Neuronal acetylcholine receptor subunit alpha-2 | CHRN alpha | C00002218 | 1 / 1 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00002553 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002553 | 1 / 1 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1135 | CHRNA2 | cholinergic receptor, nicotinic, alpha 2 (neuronal) |
C00002218
|
| 1136 | CHRNA3, LNCR2, NACHRA3, PAOD2 | cholinergic receptor, nicotinic, alpha 3 (neuronal) |
C00002218
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00002218
|
| 1139 | CHRNA7, CHRNA7-2, NACHRA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) |
C00002218
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00002218
|
| 1143 | CHRNB4 | cholinergic receptor, nicotinic, beta 4 (neuronal) |
C00002218
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (50)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #610353 | Epilepsy, nocturnal frontal lobe, 4; enfl4 |
Q15822
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P00533
P04637 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #265000 | Multiple pterygium syndrome, escobar variant; evmps |
P07510
|
| #253290 | Multiple pterygium syndrome, lethal type; lmps |
P02708
P07510 Q07001 |
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #608931 | Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency |
P11230
|
| #608930 | Myasthenic syndrome, congenital, fast-channel |
P02708
Q07001 |
| #601462 | Myasthenic syndrome, congenital, slow-channel; sccms |
P02708
P11230 Q07001 |
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #612052 | Smoking as a quantitative trait locus 3; sqtl3 |
P32297
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (71)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00770 | Congenital myasthenic syndrome |
P02708
(related)
P11230 (related) Q07001 (related) |
| H00986 | Multiple pterygium syndrome |
P02708
(related)
P07510 (related) Q07001 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) Q15822 (related) |
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|