Daphniphyllum oldhami
Species
KNApSAcK Entry
| Organism name | Daphniphyllum oldhami |
|---|---|
| Genus | Daphniphyllum |
| Family | Daphniphyllaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Daphniphyllum oldhamii |
|---|---|
| Linked NCBI taxonomy ID | 1008903 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Daphniphyllaceae |
|---|---|
| ID | 4386 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (37)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002227
|
Matrine
/ (+)-Matrine |
CHEMBL204860
CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581 |
C034244
|
5 / 3 / 7 | 4 / 5 | No. 85 | No. 3 |
|
|
C00002207
|
Anagyrine
/ (-)-Anagyrine |
CHEMBL203399
CHEMBL509692 CHEMBL1324708 CHEMBL1454284 |
C012736
|
7 / 8 / 11 | No. 384 | No. 3 |
|
|
|
C00002215
|
Camoensine
|
No. 384 | No. 3 |
|
||||
|
C00040720
|
Yuzurimine B
|
No. 584 |
|
|||||
|
C00040721
|
Yuzurimine E
/ (-)-Yuzurimine E |
No. 584 |
|
|||||
|
C00039690
|
Macrodaphniphyllidine
|
No. 584 |
|
|||||
|
C00038684
|
Calyciphylline B
|
No. 1167 |
|
|||||
|
C00038943
|
Daphnioldhanin J
/ (-)-Daphnioldhanin J |
CHEMBL465875
|
No. 1167 |
|
||||
|
C00038986
|
Deoxycalyciphylline B
/ (-)-Deoxycalyciphylline B |
No. 1167 |
|
|||||
|
C00038932
|
Daphnilactone B
/ (-)-Daphnilactone B |
No. 1167 |
|
|||||
|
C00039435
|
Isodaphnilactone B
|
No. 1167 |
|
|||||
|
C00038989
|
Deoxyisocalyciphylline B
/ (-)-Deoxyisocalyciphylline B |
No. 1167 |
|
|||||
|
C00007758
|
Oxymatrine
/ Ammothamnine / Matrine N-oxide / (+)-Matrine N-oxide / Matrine 1beta-oxide |
CHEMBL458337
CHEMBL1358502 |
C037573
|
3 / 11 / 6 | 0 / 4 | No. 1211 | No. 3 |
|
|
C00038942
|
Daphnioldhanin I
|
No. 1333 |
|
|||||
|
C00038926
|
Daphmacrine
|
No. 1333 |
|
|||||
|
C00038927
|
Daphmacropodine
|
No. 1333 |
|
|||||
|
C00038941
|
Daphnioldhanin G
/ (-)-Daphnioldhanin G |
CHEMBL1078304
|
No. 1333 |
|
||||
|
C00038938
|
Daphnioldhanin D
|
No. 1333 |
|
|||||
|
C00038940
|
Daphnioldhanin F
/ (-)-Daphnioldhanin F |
No. 1333 |
|
|||||
|
C00038939
|
Daphnioldhanin E
/ (-)-Daphnioldhanin E |
No. 1333 |
|
|||||
|
C00040267
|
Secodaphniphylline
|
No. 1457 |
|
|||||
|
C00038818
|
Codaphniphylline
/ (+)-Codaphniphylline |
No. 1457 |
|
|||||
|
C00038934
|
Daphnimacropine
|
No. 1457 |
|
|||||
|
C00038933
|
Daphnilongeranin D
|
No. 1457 |
|
|||||
|
C00038957
|
Dehydrodaphnigraciline
|
CHEMBL465534
|
No. 1714 |
|
||||
|
C00040722
|
Yuzurine
|
No. 1714 |
|
|||||
|
C00038931
|
Daphnigraciline
|
No. 1714 |
|
|||||
|
C00007759
|
Sophocarpine
/ (-)-Sophocarpine |
CHEMBL377725
CHEMBL380909 |
C035933
|
0 / 1 | No. 1721 |
|
||
|
C00039756
|
Methyl homosecodaphniphyllate
|
No. 2618 |
|
|||||
|
C00038928
|
Daphmanidin A
/ (-)-Daphmanidin A |
CHEMBL519114
|
No. 2948 |
|
||||
|
C00038937
|
Daphnioldhanin C
|
No. 3743 |
|
|||||
|
C00038935
|
Daphnioldhanin A
/ (-)-Daphnioldhanin A |
No. 3743 |
|
|||||
|
C00038936
|
Daphnioldhanin B
/ (-)-Daphnioldhanin B |
No. 3743 |
|
|||||
|
C00047838
|
Dapholdhamine A
|
CHEMBL563837
|
No. 4190 |
|
||||
|
C00047839
|
Dapholdhamine B
/ (-)-Dapholdhamine B |
CHEMBL561787
|
No. 4190 |
|
||||
|
C00047840
|
Dapholdhamine C
/ (-)-Dapholdhamine C |
CHEMBL552401
|
No. 5234 |
|
||||
|
C00047841
|
Dapholdhamine D
/ (-)-Dapholdhamine D |
CHEMBL563419
|
No. 5234 |
|
Human Protein / Gene in interactions
13 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002207 C00002227 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00002207 C00002227 | 2 / 5 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002227 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002227 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00007758 | 7 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00007758 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002207 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002207 | 3 / 3 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002207 | 1 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00007758 | 4 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002207 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002227 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002207 | 1 / 0 |
4 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00002227
|
| 4893 | NRAS, ALPS4, N-ras, NRAS1, NS6 | neuroblastoma RAS viral (v-ras) oncogene homolog |
C00002227
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00002227
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002227
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (19)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (17)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
9 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D007249 | Inflammation |
C00007759
C00007758 |
| D008113 | Liver Neoplasms |
C00002227
|
| D056487 | Drug-Induced Liver Injury, Chronic |
C00002227
|
| D006331 | Heart Diseases |
C00002227
|
| D002779 | Cholestasis |
C00002227
|
| D002289 | Carcinoma, Non-Small-Cell Lung |
C00002227
|
| D003092 | Colitis |
C00007758
|
| D019694 | Hepatitis B, Chronic |
C00007758
|
| D008106 | Liver Cirrhosis, Experimental |
C00007758
|