KCF-S cluster No. 14 (180 metabolites)

Corresponding Phytochemical cluster No. 15


KEGG BRITE br08003 External link 512


Categories (2)

br08003 Category # of metabolite
Isoflavones 1
Xanthenes 2

metabolites link (3)

br08003 Category KEGG ID KNApSAcK ID
Isoflavones C10518 C00002561
Xanthenes C10063 C00002951
Xanthenes C10080 C00002963

Metabolite list (180)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00002561 External link 512 Piscerythramine
/ 4'-Amino-5,7,3'-trihydroxy-5'-methoxy-2',6'-diprenylisoflavone
C00002951 External link 512 Gartanin
CHEMBL487992
4 / 3 / 2
C00002963 External link 512 Mangostin
/ alpha-Mangostin
CHEMBL323197
C021053
25 / 27 / 58 0 / 3
C00004016 External link 512 5-Methoxy-7,8-diprenylflavone
C00004017 External link 512 Gancaonin Q
C00004018 External link 512 Rubraflavone A
C00004023 External link 512 Rubraflavone B
C00004027 External link 512 Albanin E
C00004028 External link 512 Mulberrin
/ Kuwanon C
/ Norartocarpin
/ 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL518543
3 / 0 / 3
C00004030 External link 512 Kuwanon T
/ 2-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00004032 External link 512 Artocarpin
/ 2',4',5-Trihydroxy-7-methoxy-6-(3-methyl-1-butenyl)-3-(3-methyl-2-butenyl)flavone
/ 2-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methyl-1-butenyl)-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00004033 External link 512 Brosimone H
C00004035 External link 512 Cannflavin A
C00004037 External link 512 Rubraflavone C
C00004041 External link 512 Dihydrocycloartomunin
C00004061 External link 512 Cyclomulberrin
C00004062 External link 512 Isoartocarpin
/ Cycloartocarpin
C00004099 External link 512 Isocyclomulberrin
/ (+)-3,8,10-Trihydroxy-9-(3-methyl-2-butenyl)-6-(2-methyl-1-propenyl)-6H,7H-[1]benzopyrano[4,3-b][1]benzopyran-7-one
CHEMBL485976
C00004100 External link 512 Cycloaltilisin
/ (+)-2,8,10-Trihydroxy-3-methoxy-11-(3-methyl-2-butenyl)-6-(2-methyl-1-propenyl)-6H,7H-[1]benzopyrano[4,3-b][1]benzopyran-7-one
C00004103 External link 512 Dihydroisocycloartomunin
/ 3,8,10-Trihydroxy-2-methoxy-11-(3-methyl-2-butenyl)-6-(2-methyl-1-propenyl)-6H,7H-[1]benzopyrano[4,3-b][1]benzopyran-7-one
C00004995 External link 512 Macarangin
/ (E)-6-(3,7-dimethyl-2,6-octadienyl)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-Benzopyran-4-one
/ 6-[(2E)-3,7-Dimethyl-2,6-octadienyl]-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL478764
1 / 2 / 0
C00005020 External link 512 Glyasperin A
/ 3,5,7-Trihydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)phenyl]-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00005021 External link 512 Kushenol C
C00005029 External link 512 Broussoflavonol F
/ 3,5,7-Trihydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)phenyl]-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL464007
1 / 2 / 2
C00005032 External link 512 Broussoflavonol B
C00005033 External link 512 Broussoflavonol C
C00005034 External link 512 Broussoflavonol G
CHEMBL516319
C00009515 External link 512 Lupalbigenin
/ 5,7,4'-Trihydroxy-6,3'-diprenylisoflavone
CHEMBL463936
C00009516 External link 512 6,8-Diprenylgenistein
/ 8-(gamma,gamma-Dimethylallyl)wighteone
/ 5,7,4'-Trihydroxy-6,8-diprenylisoflavone
CHEMBL494252
12 / 14 / 11
C00009523 External link 512 Angustone A
/ 5,7,2',4'-Tetrahydroxy-6,3'-diprenylisoflavone
C00009524 External link 512 6,8-Diprenylorobol
/ 5,7,3',4'-Tetrahydroxy-6,8-diprenylisoflavone
C00009839 External link 512 2'-Methoxylupalbigenin
/ 5,7,4'-Trihydroxy-2'-methoxy-6,3'-diprenylisoflavone
C00009840 External link 512 Flemiphyllin
/ 5,7,4'-Trihydroxy-8,3',5'-triprenylisoflavone
C00009841 External link 512 6,8-Diprenylpratensein
/ 5,7,3'-Trihydroxy-4'-methoxy-6,8-diprenylisoflavone
C00009882 External link 512 3',5'-Diprenylgenistein
/ 5,7,4'-Trihydroxy-3',5'-diprenylisoflavone
C00009916 External link 512 Lupinisol C
C00009922 External link 512 Isoangustone A
/ 5,7,3',4'-Tetrahydroxy-6,5'-diprenylisoflavone
C00009924 External link 512 Pumilaisoflavone C
/ 5,7,4'-Trihydroxy-3',5'-dimethoxy-6,2'-diprenylisoflavone
C00009925 External link 512 Lupinisol A
C00009926 External link 512 Lupinisol B
C00009936 External link 512 2'-Hydroxyisolupalbigenin
/ 5,7,2',4'-Tetrahydroxy-8,3'-diprenylisoflavone
C00009940 External link 512 8-Prenylluteone
/ 5,7,2',4'-Tetrahydroxy-6,8-diprenylisoflavone
C00009941 External link 512 Euchrenone b5
/ 5,7,2'-Trihydroxy-4',5'-methylenedioxy-6,8-diprenylisoflavone
C00009942 External link 512 Euchrenone b4
/ 5,7-Dihydroxy-2'-methoxy-4',5'-methylenedioxy-6,8-diprenylisoflavone
C00009951 External link 512 Euchrenone b1
/ 5,7,4'-Trihydroxy-6,8,3'-triprenylisoflavone
C00009952 External link 512 Euchrenone b2
/ 5,7,2',4'-Tetrahydroxy-6,8,3'-triprenylisoflavone
C00010027 External link 512 Erycristagallin
/ 3,9-Dihydroxy-2,10-diprenylpterocarpene
CHEMBL462699
1 / 0 / 0
C00010068 External link 512 Lupinalbin F
C00010069 External link 512 Euchretin B
C00010070 External link 512 8-Prenyllisetin
/ 8-Dimethylallyllisetin
C00010071 External link 512 Euchretin C
/ 5,7,4',5'-Tetrahydroxy-6,8,3'-triprenylcoumaronochromone
C00011152 External link 512 7-O-Methylisolupalbigenin
CHEMBL463146
C00013408 External link 512 5,7-Dihydroxy-2-[4-hydroxy-3-(2-hydroxy-3-methyl-3-butenyl)phenyl]-6-(2-hydroxy-3-methyl-3-butenyl)-4H-1-benzopyran-4-one
C00013411 External link 512 Moralbanone
/ 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-4H-1-benzopyran-4-one
C00013412 External link 512 Cudraflavone C
/ 2',4',5,7-Tetrahydroxy-3,6-bis(3-methyl-2-butenyl)flavone
/ 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL485777
C00013413 External link 512 Artocommunol CD
/ 2-(2,4-Dihydroxyphenyl)-3-[(2E)-3,7-dimethyl-2,6-octadienyl]-5,7-dihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00013414 External link 512 Cudraflavone D
/ 2-[2,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00013415 External link 512 Artelasticin
/ 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6,8-tris(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL1985303
C00013416 External link 512 Dorsilurin D
/ (+)-2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-8-(2-hydroxy-3-methyl-3-butenyl)-3,6-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00013417 External link 512 Dorsilurin A
/ 2-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-6,8-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00013420 External link 512 Epimedokoreanin B
/ 2-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00013421 External link 512 Heteroartonin A
/ 2-[2,5-Dihydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00013516 External link 512 Isomacarangin
/ 8-[(2Z)-3,7-Dimethyl-2,6-octadienyl]-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00013517 External link 512 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL516427
C00013522 External link 512 Broussonol E
/ Papyriflavonol A
/ 2-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-3,5,7-trihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL457303
C00013523 External link 512 Broussonol D
/ 2-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-3,5,7-trihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL458762
C00013525 External link 512 Dorsmanin D
/ 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,8-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00018864 External link 512 Lespedezol A5
/ 3,8,9-Trihydroxy-7-(methylmethanoate)-10-(3,7-dimethyl-2,6-octadienyl)pterocarpene
C00018870 External link 512 Lespedezol E1
/ 5,7,4'-Trihydroxy-8-(3,7-dimethyl-2,6-octadienyl)isoflavone
C00018871 External link 512 Lespedezol E2
/ 7,2',4',5'-Tetrahydroxy-3'-(3,7-dimethyl-2,6-octadienyl)isoflavone
C00018939 External link 512 Lespedezol A2
/ 3,8,9-Trihydroxy-10-(3,7-dimethyl-2,6-octadienyl)pterocarpene
C00018941 External link 512 Lespedezol B1
/ 5,6,2',4'-Tetrahydroxy-3-methyl-7-(3,7-dimethyl-2,6-octadienyl)-2-arylbenzofuran
C00018944 External link 512 Lespedezol C1
/ 7,4',5'-Trihydroxy-3-(3,7-dimethyl-2.,6-octadienyl)coumaronochromone
C00018965 External link 512 Erysubin F
CHEMBL2159045
1 / 0 / 0
C00019046 External link 512 Isolupalbigenin
CHEMBL461061
2 / 1 / 1
C00019057 External link 512 Isoerysenegalensein E
/ 5,7,4'-Trihydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-8-prenylisoflavone
CHEMBL559714
C00019062 External link 512 Erysenegalensein E
CHEMBL557493
C00019081 External link 512 Derrisisoflavone A
C00019092 External link 512 Derrisisoflavone D
/ 7,4'-Dihydroxy-5-methoxy-6-(2-hydroxy-3-methyl-3-butenyl)-8-prenylisoflavone
C00019093 External link 512 Derrisisoflavone E
/ 7,4'-Dihydroxy-5-methoxy-8-(2-hydroxy-3-methyl-3-butenyl)-6-prenylisoflavone
C00019095 External link 512 Derrisisoflavone B
/ 5,7,4'-Trihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-6-prenylisoflavone
C00019101 External link 512 Erysenegalensein N
/ 5,7,2',4'-Tetrahydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-8-prenylisoflavone
C00019103 External link 512 Erysenegalensein D
C00019248 External link 512 Millewanin A
/ 5,7,4'-Trihydroxy-3'-methoxy-2',5'-diprenylisoflavone
C00019249 External link 512 Millewanin B
/ 5,7,4'-Trihydroxy-3'-methoxy-5'-((2E)-3,7-dimethyl-2,6-octadienyl)-2'-prenylisoflavone
C00019250 External link 512 Millewanin C
/ 5,7,3',4'-Tetrahydroxy-5'-((2E)-3,7-dimethyl-2,6-octadienyl)-2-prenylisoflavone
C00019251 External link 512 Millewanin D
/ 5,7,4'-Trihydroxy-5'-((2E)-3,7-dimethyl-2,6-octadienyl)-2'-prenylisoflavone
C00019284 External link 512 Vogelin C
/ 5,7,2',4'-Tetrahydroxy-8,5'-diprenylisoflavone
C00019286 External link 512 Flemiphilippinin B
/ 5,7-Dihydroxy-3',4'-dimethoxy-6,8-diprenylisoflavone
C00019324 External link 512 Sanggenol B
C00019400 External link 512 Euchrenone b14
/ 5,7,4'-Trihydroxy-2'-methoxy-6,8,3-triprenylisoflavone
C00019401 External link 512 Euchrenone b15
/ 5,7,4'-Trihydroxy-2'-methoxy-6,8-diprenylisoflavone
C00019412 External link 512 Euchretin N
/ 5,7,4'-Trihydroxy-5'-methoxy-6,8,3'-triprenylcoumaronochromone
C00019413 External link 512 Euchretin F
C00019666 External link 512 Isopiscerythramine
/ 4'-Amino-5,7',3'-trihydroxy-5'-methoxy-8,2'-diprenylisoflavone
C00019723 External link 512 Erythbigenin
/ 5,7,3',4'-Tetrahydroxy-5'-methoxy-2',6'-diprenylisoflavone
C00019741 External link 512 Eryvarin E
/ 3-Hydroxy-9-methoxy-2,10-diprenylpterocarpan
C00023981 External link 512 Emericellin
/ Variecoxanthone B
CHEMBL525537
C00023982 External link 512 Variecoxanthone C
C00024199 External link 512 Gerontoxanthone H
CHEMBL514057
9 / 9 / 4
C00029359 External link 512 1,3,7-Trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone
CHEMBL1782240
1 / 0 / 0
C00029554 External link 512 5,7-Dihydroxy-4'-methoxy-6,8-diprenylisoflavone
C00029600 External link 512 8-Deoxygartanin
CHEMBL488606
3 / 2 / 2
C00029819 External link 512 beta-Mangostin
CHEMBL261706
3 / 0 / 0
C00029882 External link 512 Calycinoxanthone D
/ (+)-Calycinoxanthone D
C00029995 External link 512 Cochinchinone A
CHEMBL1782241
1 / 0 / 0
C00030036 External link 512 Cudratricusxanthone E
CHEMBL1173562
C00030075 External link 512 Cyclocommunin
CHEMBL485976
C00030162 External link 512 Dulxanthone B
CHEMBL2147809
C00030348 External link 512 Normangostin
/ gamma-Mangostin
CHEMBL260553
C102777
5 / 2 / 5
C00030359 External link 512 Garcinone E
CHEMBL454580
25 / 20 / 15
C00030726 External link 512 Mangostinone
CHEMBL481310
1 / 2 / 2
C00030834 External link 512 Norcowanin
CHEMBL463409
C00030932 External link 512 Parvifolixanthone B
C00031249 External link 512 Rubraxanthone
CHEMBL458846
C472155
C00031806 External link 512 Garciniaxanthone E
C00034778 External link 512 7-O-Methylgarcinone E
CHEMBL463410
C00034819 External link 512 Cochinchinone B
CHEMBL1173563
C00034821 External link 512 Cowanin
CHEMBL458845
C00034822 External link 512 Cowanol
CHEMBL463408
C00034823 External link 512 Cowaxanthone
CHEMBL517161
C00034825 External link 512 Cowaxanthone B
C00034828 External link 512 Cowaxanthone E
C00034838 External link 512 Dulcisxanthone E
C00034845 External link 512 Fuscaxanthone C
CHEMBL464524
1 / 0 / 0
C00034929 External link 512 Artochamin D
C00035277 External link 512 Cowagarcinone A
C00035280 External link 512 Cowagarcinone E
C00035298 External link 512 Dulcisxanthone B
C00035339 External link 512 Mangostenol
C00036374 External link 512 1,3,5-Trihydroxy-4,8-di(3-methylbut-2-enyl)-xanthone
C00036389 External link 512 1,6-Dihydroxy-2-(2-hydroxy-3-methylbut-3-enyl)-3,7-dimethoxy-8-(3-methylbut-2-enyl) xanthone
C00036438 External link 512 1-Hydroxy-8-(2-hydroxy-3-methylbut-3-enyl)-3,6,7-trimethoxy-2-(3-methylbut-2-enyl) xanthone
C00036564 External link 512 4,2',4'-Trihydroxy-3'-prenylchalcone
CHEMBL187247
CHEMBL482023
1 / 1 / 1
C00036965 External link 512 Cudraxanthone F
C00037076 External link 512 Dulciol A
C00037077 External link 512 Dulciol B
C00037078 External link 512 Dulciol C
C00037326 External link 512 Isocowanin
C00037327 External link 512 Isocowanol
C472156
C00037511 External link 512 Montrouxanthone
C00037549 External link 512 Nervosaxanthone
C00037745 External link 512 Roeperanone
/ (+)-Roeperanone
C00037856 External link 512 Subelliptenone A
C00038332 External link 512 8-Hydroxycudraxanthone G
CHEMBL480167
1 / 2 / 2
C00038877 External link 512 Cudratricusxanthone K
CHEMBL228335
C00038881 External link 512 Cudraxanthone G
CHEMBL494664
1 / 2 / 2
C00039041 External link 512 Dorsilurin F
CHEMBL489270
C00039042 External link 512 Dorsilurin G
/ (-)-Dorsilurin G
CHEMBL489067
C00040327 External link 512 Smeathxanthone A
CHEMBL480158
1 / 2 / 2
C00041297 External link 512 8-Lavandulylkaempferol
CHEMBL463941
C00041559 External link 512 Glycyrrhizol A
CHEMBL522282
C00041675 External link 512 Millewanin G
/ (+)-Millewanin G
CHEMBL522471
1 / 1 / 1
C00041676 External link 512 Millewanin H
/ (+)-Millewanin H
CHEMBL523654
1 / 1 / 1
C00042242 External link 512 Artelasticinol
CHEMBL464516
C00043245 External link 512 Adenaflorin B
CHEMBL463699
C00044578 External link 512 Brasixanthone G
C00044660 External link 512 Cratoxyarborenone A
CHEMBL465205
C00044661 External link 512 Cratoxyarborenone B
CHEMBL465407
C00044662 External link 512 Cratoxyarborenone C
CHEMBL459105
C00044664 External link 512 Cratoxyarborenone E
CHEMBL462716
C00044770 External link 512 Fuscaxanthone D
C00044771 External link 512 Fuscaxanthone E
C00044772 External link 512 Fuscaxanthone F
C00045573 External link 512 5,7,2',4-Tetrahydroxy-3-geranylflavone
CHEMBL458187
1 / 2 / 2
C00045574 External link 512 5,7,3',4'-Tetrahydroxy-3-methoxy-6-geranylflavone
CHEMBL457262
1 / 2 / 2
C00045575 External link 512 5,7,3',4'-Tetrahydroxy-6-geranylflavonol
CHEMBL457261
1 / 2 / 2
C00046278 External link 512 Parvixanthone A
C00046279 External link 512 Parvixanthone B
C00046280 External link 512 Parvixanthone C
/ (-)-Parvixanthone C
C00046281 External link 512 Parvixanthone D
C00046282 External link 512 Parvixanthone E
C00046283 External link 512 Parvixanthone F
C00046284 External link 512 Parvixanthone G
/ (-)-Parvixanthone G
C00046285 External link 512 Parvixanthone H
/ (+)-Parvixanthone H
C00047281 External link 512 Lespecyrtin F2
CHEMBL551908
C00047320 External link 512 Oblongixanthone B
C00047321 External link 512 Oblongixanthone C
CHEMBL564269
C00047927 External link 512 Isoemericellin
C00048250 External link 512 1,5-Dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone

Human Protein / Gene in interactions

56 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00002951 C00002963 C00005029 C00029600 C00030348 C00030359 C00030726 C00038332 C00038881 C00040327 C00045573 C00045574 C00045575 2 / 2
Q04206 Transcription factor p65 Transcription Factor C00002951 C00002963 C00029359 C00029600 C00029819 C00029995 C00030348 C00034845 0 / 0
P49327 Fatty acid synthase Transferase C00002963 C00029819 C00030348 C00030359 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002951 C00002963 C00029600 C00029819 0 / 0
Q99700 Ataxin-2 Unclassified protein C00009516 C00024199 C00030359 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00009516 C00024199 C00030359 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00009516 C00024199 C00030359 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002963 C00009516 C00030359 4 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00009516 C00024199 C00030359 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00009516 C00024199 C00030359 2 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00009516 C00024199 C00030359 1 / 0
O75496 Geminin Unclassified protein C00009516 C00024199 C00030359 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002963 C00009516 C00030359 0 / 0
P03372 Estrogen receptor NR3A1 C00019046 C00041675 C00041676 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00009516 C00030359 0 / 0
O14763 Tumor necrosis factor receptor superfamily member 10B Unclassified protein C00002951 C00002963 1 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00004028 C00030348 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00004028 C00030348 0 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00002963 C00030359 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002963 C00030359 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00009516 C00030359 0 / 3
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002963 2 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00002963 2 / 2
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00030359 7 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002963 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00030359 1 / 1
P54132 Bloom syndrome protein Enzyme C00030359 1 / 2
O60906 Sphingomyelin phosphodiesterase 2 Enzyme C00002963 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00019046 0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002963 0 / 1
P56817 Beta-secretase 1 A1A C00004028 0 / 0
Q00987 E3 ubiquitin-protein ligase Mdm2 Other nuclear protein C00002963 1 / 5
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002963 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00004995 2 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002963 2 / 2
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00036564 1 / 1
P37840 Alpha-synuclein Unclassified protein C00024199 4 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002963 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00030359 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002963 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002963 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002963 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00030359 0 / 0
P04062 Glucosylceramidase Enzyme C00009516 6 / 4
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00030359 0 / 0
P06746 DNA polymerase beta Enzyme C00030359 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002963 1 / 0
P04054 Phospholipase A2 Enzyme C00010027 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00030359 0 / 0
P17861 X-box-binding protein 1 Unclassified protein C00030359 1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002963 7 / 37
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00030359 0 / 0
O00255 Menin Unclassified protein C00002963 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002963 1 / 2
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00018965 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00024199 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (54)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614401 Accelerated tumor formation, susceptibility to; actfs Q00987
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#300615 Brunner syndrome P21397
#114500 Colorectal cancer; crc P18054
P84022
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#612371 Major affective disorder 7; mafd7 P17861
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc O14763
P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (74)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
Q00987 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
Q00987 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
Q00987 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
Q00987 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00037 Alveolar rhabdomyosarcoma Q00987 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00002963
D009202 Cardiomyopathies C00002963
D009203 Myocardial Infarction C00002963