Coptis spp.
Species
KNApSAcK Entry
| Organism name | Coptis spp. |
|---|---|
| Genus | Coptis |
| Family | Ranunculaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Coptis |
|---|---|
| Linked NCBI taxonomy ID | 3441 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Ranunculaceae |
|---|---|
| ID | 3440 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (31)
| Species | Activity |
|---|---|
| Coptis spp. | Alexeteric |
| Coptis spp. | Amebicide |
| Coptis spp. | Analgesic |
| Coptis spp. | Antiacetylcholinesterase |
| Coptis spp. | Antialzheimeran |
| Coptis spp. | Antiarthritic |
| Coptis spp. | Antibacterial |
| Coptis spp. | Anticancer |
| Coptis spp. | Antidote, daylily |
| Coptis spp. | Antidysenteric |
| Coptis spp. | Antigiardic |
| Coptis spp. | Antihelicobacter |
| Coptis spp. | Antiinflammatory |
| Coptis spp. | Antiperiodic |
| Coptis spp. | Antiperistaltic |
| Coptis spp. | Antipyretic |
| Coptis spp. | Antisecretory |
| Coptis spp. | Antiseptic |
| Coptis spp. | Antitrypanosomic |
| Coptis spp. | Antiulcer |
| Coptis spp. | Astringent |
| Coptis spp. | Bitter |
| Coptis spp. | cAMP-Inhibitor |
| Coptis spp. | Candidicide |
| Coptis spp. | Collyrium |
| Coptis spp. | Digestive |
| Coptis spp. | Hypoglycemic |
| Coptis spp. | Mutagenic |
| Coptis spp. | Stomachic |
| Coptis spp. | Tonic |
| Coptis spp. | Trichomonicide |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001819
|
Thalsine
/ Majarine / Berberine / Umbellatin |
CHEMBL295124
|
D001599
|
19 / 25 / 26 | 30 / 19 | No. 155 | No. 4 |
|
|
C00026154
|
Thalifendine
|
CHEMBL1187148
|
C477156
|
No. 155 | No. 4 |
|
||
|
C00026131
|
Groenlandicine
|
No. 155 | No. 4 |
|
||||
|
C00026130
|
Epiberberine
|
CHEMBL1197637
|
C061432
|
22 / 34 / 27 | No. 155 | No. 4 |
|
|
|
C00025997
|
Berlambine
/ Oxyberberine / 8-Oxoberberine |
CHEMBL11531
|
No. 439 |
|
Human Protein / Gene in interactions
36 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001819 C00026130 | 4 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001819 C00026130 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00001819 C00026130 | 2 / 5 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001819 C00026130 | 4 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001819 C00026130 | 0 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00026130 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00026130 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00026130 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001819 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001819 | 0 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00026130 | 1 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001819 | 2 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001819 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00026130 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00026130 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00026130 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00026130 | 1 / 1 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00001819 | 1 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00026130 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001819 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00026130 | 2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001819 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001819 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00026130 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00026130 | 1 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00001819 | 0 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00001819 | 5 / 5 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00026130 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00026130 | 0 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00026130 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00001819 | 1 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001819 | 1 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001819 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001819 | 1 / 4 |
| Q9UBT2 | SUMO-activating enzyme subunit 2 | Enzyme | C00026130 | 0 / 0 |
| Q9UBE0 | SUMO-activating enzyme subunit 1 | Unclassified protein | C00026130 | 0 / 0 |
30 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00001819
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001819
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001819
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00001819
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00001819
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001819
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00001819
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001819
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00001819
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001819
|
| 894 | CCND2, KIAK0002 | cyclin D2 |
C00001819
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00001819
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00001819
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00001819
|
| 1021 | CDK6, PLSTIRE | cyclin-dependent kinase 6 (EC:2.7.11.22) |
C00001819
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001819
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00001819
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00001819
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001819
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00001819
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00001819
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00001819
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001819
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00001819
|
| 5027 | P2RX7, P2X7 | purinergic receptor P2X, ligand-gated ion channel, 7 |
C00001819
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001819
|
| 6476 | SI | sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48) |
C00001819
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001819
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001819
|
| 7185 | TRAF1, EBI6, MGC:10353 | TNF receptor-associated factor 1 |
C00001819
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (48)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #609135 | Aplastic anemia |
O14746
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (42)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
|
| H00024 | Prostate cancer |
O14746
(marker)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
19 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00001819
|
| D001862 | Bone Resorption |
C00001819
|
| D002471 | Cell Transformation, Neoplastic |
C00001819
|
| D003556 | Cystitis |
C00001819
|
| D003920 | Diabetes Mellitus |
C00001819
|
| D003921 | Diabetes Mellitus, Experimental |
C00001819
|
| D003924 | Diabetes Mellitus, Type 2 |
C00001819
|
| D004487 | Edema |
C00001819
|
| D006470 | Hemorrhage |
C00001819
|
| D006937 | Hypercholesterolemia |
C00001819
|
| D006943 | Hyperglycemia |
C00001819
|
| D006949 | Hyperlipidemias |
C00001819
|
| D006973 | Hypertension |
C00001819
|
| D007077 | Ileal Diseases |
C00001819
|
| D007333 | Insulin Resistance |
C00001819
|
| D007410 | Intestinal Diseases |
C00001819
|
| D009369 | Neoplasms |
C00001819
|
| D010190 | Pancreatic Neoplasms |
C00001819
|
| D011471 | Prostatic Neoplasms |
C00001819
|