Species

KNApSAcK Entry

Organism name Papaver confine
Genus Papaver
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Papaver
Linked NCBI taxonomy ID 3468
Linked level genus

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025655 External link 512 Corytuberine
/ (+)-Corytuberine
CHEMBL227965
C013896
1 / 0 / 0 No. 20 No. 4
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00025827 External link 512 Corydine
/ Glaucentrin
/ (+)-Corydine
/ Glaucentrine
CHEMBL489524
CHEMBL2002847
C067341
1 / 0 / 0 No. 20 No. 4
C00026095 External link 512 Stylopine
/ (-)-Stylopine
/ l-Tetrahydrocoptisine
/ (-)-Tetrahydrocoptisine
CHEMBL1922602
No. 37 No. 4
C00026092 External link 512 Scoulerine
/ (-)-Scoulerine
CHEMBL191133
CHEMBL1235966
CHEMBL1395394
27 / 19 / 15 No. 37 No. 4
C00026144 External link 512 Sinactine
/ Tetrahydroepiberberine
No. 37 No. 4
C00026118 External link 512 Corysamine
No. 155 No. 4
C00001819 External link 512 Thalsine
/ Majarine
/ Berberine
/ Umbellatin
CHEMBL295124
D001599
19 / 25 / 26 30 / 19 No. 155 No. 4
C00025457 External link 512 Papaverrubin A
/ Papaverrubine A
/ N-Demethylisorheadine
No. 305
C00025461 External link 512 Papaverrubine E
No. 305
C00025459 External link 512 Papaverrubine C
/ Epiporphyroxine
/ 14-Epiporphyroxine
No. 305
C00025460 External link 512 Porphyroxine
/ Papaverrubine D
No. 305
C00001911 External link 512 Rhoeadine
C019078
No. 305
C00001886 External link 512 Mecambrine
/ (-)-Fugapavine
/ (-)-Mecambrine
No. 688
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4
C00027332 External link 512 Cryptopin
/ Cryptopine
/ Kryptopine
/ Kryptocavin
/ Cryptocavine
CHEMBL1339015
C007159
6 / 5 / 8 No. 820 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00001924 External link 512 Thebaine
/ (-)-Thebaine
/ Paramorphine
CHEMBL403893
CHEMBL1318110
D013797
4 / 0 / 0 No. 1983 No. 4

Human Protein / Gene in interactions

60 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001819 C00001872 C00001906 C00026092 C00027332 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001819 C00001872 C00001906 C00026092 C00027332 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 C00001819 C00025625 C00027332 1 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001819 C00001872 C00001906 C00026092 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001799 C00001924 C00025625 C00026092 0 / 0
O75496 Geminin Unclassified protein C00001872 C00001924 C00025625 C00026092 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001872 C00001906 C00026092 C00027332 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00001819 C00001872 C00025625 1 / 4
O00255 Menin Unclassified protein C00001819 C00025625 C00027332 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00001819 C00001872 C00025625 0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001819 C00001872 C00026092 0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 C00025655 C00025827 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001819 C00001872 C00026092 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025625 C00026092 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001819 C00001906 3 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 C00025625 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025625 C00026092 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001924 C00026092 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 C00026092 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001819 C00001872 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 C00026092 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001819 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025625 2 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00025625 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00026092 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00026092 1 / 1
P14416 D(2) dopamine receptor Dopamine receptor C00026092 2 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025625 1 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00027332 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00026092 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00001819 1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00026092 0 / 0
P02545 Prelamin-A/C Unclassified protein C00026092 11 / 10
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001872 3 / 3
O15118 Niemann-Pick C1 protein Unclassified protein C00025625 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025625 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026092 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001924 0 / 0
P29466 Caspase-1 C14 C00026092 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025625 1 / 1
P06746 DNA polymerase beta Enzyme C00025625 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025625 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025625 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001819 4 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001819 2 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00026092 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00026092 1 / 0
O14746 Telomerase reverse transcriptase Enzyme C00001819 5 / 5
Q9UBT6 DNA polymerase kappa Enzyme C00025625 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00026092 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00026092 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025625 1 / 1
Q99700 Ataxin-2 Unclassified protein C00026092 1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00026092 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001819 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025625 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00001819 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001819 4 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

31 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799 C00001819 C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799 C00001906
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00001819
581 BAX, BCL2L4 BCL2-associated X protein C00001819
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001819
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00001819
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001819
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001819
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00001819
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001819
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001819
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00001819
894 CCND2, KIAK0002 cyclin D2 C00001819
898 CCNE1, CCNE cyclin E1 C00001819
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00001819
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001819
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00001819
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001819
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00001819
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00001819
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00001819
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00001819
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00001819
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001819
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00001819
5027 P2RX7, P2X7 purinergic receptor P2X, ligand-gated ion channel, 7 C00001819
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001819
6476 SI sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48) C00001819
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001819
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00001819
7185 TRAF1, EBI6, MGC:10353 TNF receptor-associated factor 1 C00001819

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (52)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103780 Alcohol dependence P14416
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609135 Aplastic anemia O14746
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (43)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
H00024 Prostate cancer O14746 (marker)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

19 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00001819
D001862 Bone Resorption C00001819
D002471 Cell Transformation, Neoplastic C00001819
D003556 Cystitis C00001819
D003920 Diabetes Mellitus C00001819
D003921 Diabetes Mellitus, Experimental C00001819
D003924 Diabetes Mellitus, Type 2 C00001819
D004487 Edema C00001819
D006470 Hemorrhage C00001819
D006937 Hypercholesterolemia C00001819
D006943 Hyperglycemia C00001819
D006949 Hyperlipidemias C00001819
D006973 Hypertension C00001819
D007077 Ileal Diseases C00001819
D007333 Insulin Resistance C00001819
D007410 Intestinal Diseases C00001819
D009369 Neoplasms C00001819
D010190 Pancreatic Neoplasms C00001819
D011471 Prostatic Neoplasms C00001819