PCIDB

KNApSAcK Metabolite C00026092

Metabolite

KNApSAcK Entry

id C00026092
Name Scoulerine / (-)-Scoulerine
CAS RN 6451-73-6
Standard InChI InChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
Standard InChI (Main Layer) InChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 37

Link

ChEMBL

By standard InChI CHEMBL1235966
By standard InChI Main Layer CHEMBL191133 CHEMBL1235966 CHEMBL1395394

KEGG

By LinkDB C02106

CTD

By CAS RN

Species

Summary

Plant class

class name count
eudicotyledons 31
Magnoliophyta 2
rosids 2

Family

family name count
Papaveraceae 30
Rutaceae 1
Menispermaceae 1
Lauraceae 1
Annonaceae 1
Fabaceae 1

List (36)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Corydalis caseana A.Gray. 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis caucasia 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis gigantea Trautv.et Mey. 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis hsuchowensis 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis intermedia 54425 Papaveraceae eudicotyledons Viridiplantae
Corydalis majori 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis nobilis 38909 Papaveraceae eudicotyledons Viridiplantae
Corydalis pseudoadunca 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis sibirica Pers. 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis solida 38914 Papaveraceae eudicotyledons Viridiplantae
Corydalis stewartii 3463 Papaveraceae eudicotyledons Viridiplantae
Cryptocarya longifolia Kostermans 22027 Lauraceae Magnoliophyta Viridiplantae
Disepalum pulchrum 690737 Annonaceae Magnoliophyta Viridiplantae
Erythrina orientalis Murr. 3841 Fabaceae rosids Viridiplantae
Fumaria densiflora 1092452 Papaveraceae eudicotyledons Viridiplantae
Fumaris vaillantii Loisel.
Hunnemannia fumariaefolia Sweet 56854 Papaveraceae eudicotyledons Viridiplantae
Hypecoum procumbens L. 391933 Papaveraceae eudicotyledons Viridiplantae
Papaver albiflora 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver albiflorum (sub.spp.albiflorum, austromoravicum) 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver confine 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver lecoquii Lamotte 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver orientale 22694 Papaveraceae eudicotyledons Viridiplantae
Papaver pinnatifidum 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver rhoeas chelidonides 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver setigerum 215229 Papaveraceae eudicotyledons Viridiplantae
Papaver somniferum L. 3469 Papaveraceae eudicotyledons Viridiplantae
Papaver stevenianum 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver tauricola 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver trinifolium 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver triniifolium 400537 Papaveraceae eudicotyledons Viridiplantae
Sarcocapnos enneaphylla 38924 Papaveraceae eudicotyledons Viridiplantae
Sarcocapnos saetabensis 107196 Papaveraceae eudicotyledons Viridiplantae
Stephania cepharantha Hayata 147243 Menispermaceae eudicotyledons Viridiplantae
Stylophorum lasiocarpum 72189 Papaveraceae eudicotyledons Viridiplantae
Zanthoxylum taediosum 67937 Rutaceae rosids Viridiplantae

Human Protein / Gene in interaction

27 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1395394 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1235966 CHEMBL1395394 CHEMBL2114784 (2)
1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1235966 CHEMBL1395394 CHEMBL2343280 (2) CHEMBL2343284 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL1395394 CHEMBL1614158 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL1395394 CHEMBL1614544 (1)
11 / 10
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1395394 CHEMBL1741325 (1)
0 / 1
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL1235966 CHEMBL1395394 CHEMBL2343279 (2) CHEMBL2343283 (2)
2 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL1235966 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1235966 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL1235966 CHEMBL2114788 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL1235966 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL1235966 CHEMBL1614280 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL1235966 CHEMBL1963863 (1) CHEMBL2114934 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1395394 CHEMBL1794467 (1) CHEMBL1794492 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1395394 CHEMBL1741322 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1235966 CHEMBL1738588 (1)
0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL1235966 CHEMBL1395394 CHEMBL2343277 (2) CHEMBL2343281 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1395394 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1395394 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1235966 CHEMBL1794483 (1)
0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein CHEMBL1235966 CHEMBL1794319 (1) CHEMBL1794383 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1235966 CHEMBL1738184 (1)
0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL1235966 CHEMBL1395394 CHEMBL2343278 (2) CHEMBL2343282 (2)
1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1395394 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1235966 CHEMBL1738442 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1235966 CHEMBL1964002 (1) CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL1235966 CHEMBL2114859 (1) CHEMBL2114734 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (15)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)