Species

KNApSAcK Entry

Organism name Papaver triniifolium
Genus Papaver
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Papaver triniifolium
Linked NCBI taxonomy ID 400537
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00026092 External link 512 Scoulerine
/ (-)-Scoulerine
CHEMBL191133
CHEMBL1235966
CHEMBL1395394
27 / 19 / 15 No. 37 No. 4
C00026087 External link 512 Cheilanthifoline
/ (-)-Cheilanthifoline
No. 37 No. 4
C00025632 External link 512 Isocorypalmine
/ (-)-Isocorypalmine
/ Tetrahydrocolumbamine
/ O10-Methylstepholidine
CHEMBL2334891
CHEMBL2334892
4 / 3 / 0 No. 37 No. 4
C00026144 External link 512 Sinactine
/ Tetrahydroepiberberine
No. 37 No. 4
C00026139 External link 512 N-Methylsinactine
No. 234
C00025464 External link 512 Rhoeagenine
No. 305
C00001911 External link 512 Rhoeadine
C019078
No. 305
C00027454 External link 512 Oreodine
No. 305
C00025456 External link 512 Oreogenine
No. 305
C00001802 External link 512 Amurine
/ (+)-Amurine
No. 426 No. 4
C00001916 External link 512 Salutaridine
/ (+)-Salutaridine
CHEMBL402782
CHEMBL404097
C009270
3 / 4 / 2 No. 426 No. 4
C00027425 External link 512 N-Methylcrotonosine
No. 688
C00001886 External link 512 Mecambrine
/ (-)-Fugapavine
/ (-)-Mecambrine
No. 688
C00027331 External link 512 Crykonisine
No. 1137
C00027467 External link 512 Papavarine
CHEMBL19224
121 / 66 / 52 No. 1165 No. 4
C00027143 External link 512 Floripavidine
/ (-)-Floripavidine
/ 2-alpha-L-Rhamnosyl-N-methylasimilobine
No. 2772
C00026134 External link 512 Mecambridine
/ (-)-Oreophiline
/ (-)-Mecambridine
C051429
No. 3042

Human Protein / Gene in interactions

138 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00025632 C00026092 C00027467 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025632 C00026092 C00027467 2 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025632 C00026092 C00027467 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001916 C00027467 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00026092 C00027467 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00026092 C00027467 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00026092 C00027467 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00026092 C00027467 1 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025632 C00026092 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00026092 C00027467 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00026092 C00027467 0 / 0
P29466 Caspase-1 C14 C00026092 C00027467 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00026092 C00027467 0 / 1
P02545 Prelamin-A/C Unclassified protein C00026092 C00027467 11 / 10
P33032 Melanocortin receptor 5 Melanocortin receptor C00027467 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00027467 0 / 0
Q92793 CREB-binding protein Enzyme C00027467 1 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00027467 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00027467 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00027467 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00027467 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00027467 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00027467 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00027467 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00027467 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00027467 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00027467 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00027467 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00027467 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00027467 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001916 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00027467 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00027467 0 / 0
P17252 Protein kinase C alpha type Alpha C00027467 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00027467 1 / 8
Q13370 cGMP-inhibited 3',5'-cyclic phosphodiesterase B PDE_3B C00027467 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00027467 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00027467 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00027467 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00027467 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00027467 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00027467 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00027467 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00027467 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00027467 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00027467 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00027467 2 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00027467 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00027467 0 / 0
P39748 Flap endonuclease 1 Enzyme C00026092 0 / 0
O75496 Geminin Unclassified protein C00026092 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00027467 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00027467 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00027467 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00027467 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00027467 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00027467 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00027467 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00027467 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00027467 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00027467 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00027467 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00027467 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00027467 0 / 0
P08311 Cathepsin G S1A C00027467 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00027467 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00026092 0 / 0
P03956 Interstitial collagenase M10A C00027467 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00027467 0 / 0
Q9Y233 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE_10A C00027467 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00026092 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00026092 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00027467 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00026092 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00026092 0 / 0
P00734 Prothrombin S1A C00001916 4 / 2
P04150 Glucocorticoid receptor NR3C1 C00027467 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00027467 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00027467 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00027467 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00027467 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00027467 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00027467 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00027467 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00027467 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00027467 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00027467 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00027467 2 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00027467 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00027467 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00027467 2 / 1
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00027467 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00026092 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00027467 0 / 0
P03372 Estrogen receptor NR3A1 C00027467 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00027467 1 / 0
P22303 Acetylcholinesterase Hydrolase C00027467 1 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00027467 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00027467 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00027467 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00027467 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00027467 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00027467 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00027467 2 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00027467 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00027467 0 / 0
P08246 Neutrophil elastase S1A C00027467 2 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00027467 2 / 2
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00027467 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00026092 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00026092 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00027467 0 / 3
Q99700 Ataxin-2 Unclassified protein C00026092 1 / 1
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00027467 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00027467 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00027467 0 / 0
Q14432 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE_3A C00027467 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00027467 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00027467 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00027467 0 / 1
O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE_2A C00027467 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00027467 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00027467 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00026092 0 / 0
P40225 Thrombopoietin Unclassified protein C00027467 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00027467 4 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00026092 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00026092 0 / 0
Q14123 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C PDE_1C C00027467 0 / 0
P54750 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE_1A C00027467 0 / 0
Q01064 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE_1B C00027467 0 / 0
P27815 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE_4A C00027467 0 / 0
Q08499 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE_4D C00027467 1 / 0
Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE_4B C00027467 0 / 0
Q08493 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE_4C C00027467 0 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00027467 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00027467 2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00027467 3 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (73)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#614613 Acrodysostosis 2, with or without hormone resistance; acrdys2 Q08499
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614674 Periodic fever, menstrual cycle-dependent P08908
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180849 Rubinstein-taybi syndrome 1; rsts1 Q92793
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601367 Stroke, ischemic P00734
#187950 Thrombocythemia 1; thcyt1 P40225
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (56)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00504 Rubinstein-Taybi syndrome Q92793 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)