Corydalis majori
Species
KNApSAcK Entry
| Organism name | Corydalis majori |
|---|---|
| Genus | Corydalis |
| Family | Fumariaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Corydalis |
|---|---|
| Linked NCBI taxonomy ID | 3463 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Papaveraceae |
|---|---|
| ID | 3465 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (12)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001824
|
Bulbocapnine
/ d-Bulbocapnine |
CHEMBL157912
|
C083807
|
0 / 1 | No. 20 | No. 4 |
|
|
|
C00027488
|
Tetrahydrocorysamine
/ (+)-Tetrahydrocorysamine |
No. 37 | No. 4 |
|
||||
|
C00028013
|
Cavidine
|
CHEMBL453544
|
C011188
|
No. 37 | No. 4 |
|
||
|
C00026095
|
Stylopine
/ (-)-Stylopine / l-Tetrahydrocoptisine / (-)-Tetrahydrocoptisine |
CHEMBL1922602
|
No. 37 | No. 4 |
|
|||
|
C00026087
|
Cheilanthifoline
/ (-)-Cheilanthifoline |
No. 37 | No. 4 |
|
||||
|
C00026092
|
Scoulerine
/ (-)-Scoulerine |
CHEMBL191133
CHEMBL1235966 CHEMBL1395394 |
27 / 19 / 15 | No. 37 | No. 4 |
|
||
|
C00025629
|
Sinoacutine
/ (-)-Sinoacutine / (-)-Salutaridine |
CHEMBL402782
CHEMBL404097 |
3 / 4 / 2 | No. 426 | No. 4 |
|
||
|
C00001838
|
Corpaine
/ (-)-Corpaine |
No. 512 | No. 4 |
|
||||
|
C00028088
|
Corysolidine
|
No. 512 | No. 4 |
|
||||
|
C00001820
|
Bucuculline
/ Bicucullin / (+)-Bicuculline |
CHEMBL417990
CHEMBL1316579 CHEMBL1437488 CHEMBL1444722 |
D001640
|
30 / 28 / 20 | 0 / 21 | No. 605 | No. 4 |
|
|
C00001830
|
Capnoidine
/ l-Adlumidine / l-Capnoidine / (-)-Adlumidine / (-)-Capnoidine |
CHEMBL417990
CHEMBL1316579 CHEMBL1437488 CHEMBL1444722 |
30 / 28 / 20 | No. 605 | No. 4 |
|
||
|
C00001906
|
Fumarin
/ Biflorine / Protopine / Fumarine / Corydinine |
CHEMBL453019
|
C009093
|
5 / 5 / 4 | 2 / 0 | No. 820 | No. 4 |
|
Human Protein / Gene in interactions
52 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001820 C00001830 C00001906 C00026092 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001820 C00001830 C00001906 C00026092 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001820 C00001830 C00001906 C00026092 | 1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001820 C00001830 C00026092 | 11 / 10 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001820 C00001830 C00026092 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001820 C00001830 C00001906 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001820 C00001830 C00026092 | 0 / 1 |
| O75496 | Geminin | Unclassified protein | C00001820 C00001830 C00026092 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001820 C00001830 C00026092 | 0 / 0 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001820 C00001830 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001820 C00001830 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001820 C00001830 | 4 / 2 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001820 C00001830 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001820 C00001830 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001820 C00001830 | 0 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001820 C00001830 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001820 C00001830 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001820 C00001830 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001820 C00001830 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001820 C00001830 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001820 C00001830 | 1 / 0 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001820 C00001830 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001820 C00001830 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001820 C00001830 | 0 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00001820 C00001830 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00001820 C00001830 | 2 / 2 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001906 C00026092 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001820 C00001830 | 1 / 0 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001820 C00001830 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001820 C00001830 | 0 / 0 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00001820 C00001830 | 3 / 2 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00026092 | 1 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00026092 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00026092 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00026092 | 0 / 0 |
| O14727 | Apoptotic protease-activating factor 1 | Unclassified protein | C00026092 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00025629 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00026092 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00026092 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00025629 | 4 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00026092 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00026092 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00026092 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00026092 | 1 / 1 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00026092 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00026092 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00026092 | 2 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00025629 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00026092 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00026092 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00026092 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00026092 | 0 / 0 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001906
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001906
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (37)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103780 | Alcohol dependence |
P14416
P47869 |
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #607208 | Dravet syndrome |
P18507
P35498 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (24)
| KEGG | name | UniProt |
|---|---|---|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) P35498 (related) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
21 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D002375 | Catalepsy |
C00001824
C00001820 |
| D007022 | Hypotension |
C00001820
|
| D000648 | Amnesia, Retrograde |
C00001820
|
| D001008 | Anxiety Disorders |
C00001820
|
| D001919 | Bradycardia |
C00001820
|
| D004487 | Edema |
C00001820
|
| D004827 | Epilepsy |
C00001820
|
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00001820
|
| D006930 | Hyperalgesia |
C00001820
|
| D006973 | Hypertension |
C00001820
|
| D000647 | Amnesia |
C00001820
|
| D009069 | Movement Disorders |
C00001820
|
| D009207 | Myoclonus |
C00001820
|
| D009436 | Neural Tube Defects |
C00001820
|
| D020078 | Neurogenic Inflammation |
C00001820
|
| D020336 | Paraparesis, Spastic |
C00001820
|
| D010409 | Penile Diseases |
C00001820
|
| D049188 | Prenatal Injuries |
C00001820
|
| D012640 | Seizures |
C00001820
|
| D013035 | Spasm |
C00001820
|
| D013226 | Status Epilepticus |
C00001820
|