Species

KNApSAcK Entry

Organism name Corydalis stewartii
Genus Corydalis
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Corydalis
Linked NCBI taxonomy ID 3463
Linked level genus

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00026095 External link 512 Stylopine
/ (-)-Stylopine
/ l-Tetrahydrocoptisine
/ (-)-Tetrahydrocoptisine
CHEMBL1922602
No. 37 No. 4
C00026087 External link 512 Cheilanthifoline
/ (-)-Cheilanthifoline
No. 37 No. 4
C00026092 External link 512 Scoulerine
/ (-)-Scoulerine
CHEMBL191133
CHEMBL1235966
CHEMBL1395394
27 / 19 / 15 No. 37 No. 4
C00025629 External link 512 Sinoacutine
/ (-)-Sinoacutine
/ (-)-Salutaridine
CHEMBL402782
CHEMBL404097
3 / 4 / 2 No. 426 No. 4
C00029245 External link 512 Yenhusomidine
CHEMBL520375
No. 512 No. 4
C00027332 External link 512 Cryptopin
/ Cryptopine
/ Kryptopine
/ Kryptocavin
/ Cryptocavine
CHEMBL1339015
C007159
6 / 5 / 8 No. 820 No. 4

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00026092 C00027332 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00026092 C00027332 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00026092 C00027332 1 / 1
P00734 Prothrombin S1A C00025629 4 / 2
P02545 Prelamin-A/C Unclassified protein C00026092 11 / 10
P24941 Cyclin-dependent kinase 2 Cdc2 C00025629 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00026092 0 / 1
P14416 D(2) dopamine receptor Dopamine receptor C00026092 2 / 0
P39748 Flap endonuclease 1 Enzyme C00026092 0 / 0
O75496 Geminin Unclassified protein C00026092 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00026092 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00026092 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00026092 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00027332 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00026092 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00026092 0 / 0
P29466 Caspase-1 C14 C00026092 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00026092 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00026092 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026092 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025629 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00026092 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00026092 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00026092 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00026092 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00026092 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00026092 1 / 0
Q99700 Ataxin-2 Unclassified protein C00026092 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00026092 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00026092 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00026092 0 / 0
O00255 Menin Unclassified protein C00027332 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00027332 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (24)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)