Species

KNApSAcK Entry

Organism name Corydalis caucasia
Genus Corydalis
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Corydalis
Linked NCBI taxonomy ID 3463
Linked level genus

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00027438 External link 512 Sanjoinine Ib
/ Norisocorydine
CHEMBL465212
No. 20 No. 4
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00001824 External link 512 Bulbocapnine
/ d-Bulbocapnine
CHEMBL157912
C083807
0 / 1 No. 20 No. 4
C00025675 External link 512 Lauroscholtzine
/ 2-O-Methylboldine
/ N-Methyllaurotetanine
/ (+)-N-Methyllaurotetanine
CHEMBL464099
1 / 1 / 0 No. 20 No. 4
C00026095 External link 512 Stylopine
/ (-)-Stylopine
/ l-Tetrahydrocoptisine
/ (-)-Tetrahydrocoptisine
CHEMBL1922602
No. 37 No. 4
C00026087 External link 512 Cheilanthifoline
/ (-)-Cheilanthifoline
No. 37 No. 4
C00026092 External link 512 Scoulerine
/ (-)-Scoulerine
CHEMBL191133
CHEMBL1235966
CHEMBL1395394
27 / 19 / 15 No. 37 No. 4
C00001838 External link 512 Corpaine
/ (-)-Corpaine
No. 512 No. 4
C00027368 External link 512 Fumariline
C049095
No. 512 No. 4
C00028756 External link 512 Ochotensimine
No. 512 No. 4
C00028283 External link 512 Fumaritine
No. 512 No. 4
C00029012 External link 512 Sibiricine
/ (+)-Sibiricine
No. 512 No. 4
C00027303 External link 512 beta-Hydrastine
CHEMBL475536
CHEMBL462731
CHEMBL1256868
CHEMBL1256919
CHEMBL1408680
CHEMBL1412842
CHEMBL1441048
C013024
21 / 35 / 30 No. 605 No. 4
C00027512 External link 512 Adlumidine
/ (+)-Adlumidine
CHEMBL417990
CHEMBL1316579
CHEMBL1437488
CHEMBL1444722
30 / 28 / 20 No. 605 No. 4
C00001820 External link 512 Bucuculline
/ Bicucullin
/ (+)-Bicuculline
CHEMBL417990
CHEMBL1316579
CHEMBL1437488
CHEMBL1444722
D001640
30 / 28 / 20 0 / 21 No. 605 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4

Human Protein / Gene in interactions

70 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001820 C00001869 C00001906 C00026092 C00027303 C00027512 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001820 C00001869 C00001906 C00026092 C00027303 C00027512 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001820 C00001869 C00001906 C00026092 C00027303 C00027512 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001820 C00001869 C00026092 C00027303 C00027512 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001820 C00026092 C00027303 C00027512 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001820 C00026092 C00027303 C00027512 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001869 C00001906 C00026092 C00027303 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001820 C00026092 C00027303 C00027512 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00001820 C00001906 C00027303 C00027512 3 / 2
O75496 Geminin Unclassified protein C00001820 C00026092 C00027303 C00027512 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001799 C00026092 C00027303 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025675 C00026092 1 / 0
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00001820 C00027512 3 / 2
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00001820 C00027512 2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001820 C00027512 0 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00001820 C00027512 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001820 C00027512 1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001820 C00027512 1 / 1
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001820 C00027512 0 / 0
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001820 C00027512 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001820 C00027512 4 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 C00001869 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001820 C00027512 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001820 C00027512 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001820 C00027512 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001820 C00027512 0 / 0
P29466 Caspase-1 C14 C00001869 C00026092 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001869 C00027303 3 / 3
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001820 C00027512 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001820 C00027512 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00026092 C00027303 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001820 C00027512 0 / 0
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001820 C00027512 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001820 C00027512 1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001820 C00027512 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001820 C00027512 1 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001820 C00027512 0 / 0
Q99700 Ataxin-2 Unclassified protein C00026092 C00027303 1 / 1
P54132 Bloom syndrome protein Enzyme C00027303 1 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00026092 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00026092 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001869 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001869 4 / 3
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
P40225 Thrombopoietin Unclassified protein C00027303 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 7 / 37
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00026092 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00026092 0 / 0
O00255 Menin Unclassified protein C00001869 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00001869 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001869 1 / 4
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00026092 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00027303 2 / 2
P04062 Glucosylceramidase Enzyme C00027303 6 / 4
P55210 Caspase-7 C14 C00001869 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026092 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00027303 5 / 2
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 2 / 2
P04150 Glucocorticoid receptor NR3C1 C00027303 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00026092 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00026092 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00026092 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00026092 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00026092 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00027303 0 / 0
P39748 Flap endonuclease 1 Enzyme C00026092 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001869 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00026092 2 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799 C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799 C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (69)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P14416
P47869
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#137800 Glioma susceptibility 1; glm1 O75874
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (85)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
P35498 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

21 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00001824
C00001820
D007022 Hypotension C00001820
D000648 Amnesia, Retrograde C00001820
D001008 Anxiety Disorders C00001820
D001919 Bradycardia C00001820
D004487 Edema C00001820
D004827 Epilepsy C00001820
D005119 Extravasation of Diagnostic and Therapeutic Materials C00001820
D006930 Hyperalgesia C00001820
D006973 Hypertension C00001820
D000647 Amnesia C00001820
D009069 Movement Disorders C00001820
D009207 Myoclonus C00001820
D009436 Neural Tube Defects C00001820
D020078 Neurogenic Inflammation C00001820
D020336 Paraparesis, Spastic C00001820
D010409 Penile Diseases C00001820
D049188 Prenatal Injuries C00001820
D012640 Seizures C00001820
D013035 Spasm C00001820
D013226 Status Epilepticus C00001820