Species

KNApSAcK Entry

Organism name Papaver stevenianum
Genus Papaver
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Papaver
Linked NCBI taxonomy ID 3468
Linked level genus

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00025827 External link 512 Corydine
/ Glaucentrin
/ (+)-Corydine
/ Glaucentrine
CHEMBL489524
CHEMBL2002847
C067341
1 / 0 / 0 No. 20 No. 4
C00025655 External link 512 Corytuberine
/ (+)-Corytuberine
CHEMBL227965
C013896
1 / 0 / 0 No. 20 No. 4
C00026092 External link 512 Scoulerine
/ (-)-Scoulerine
CHEMBL191133
CHEMBL1235966
CHEMBL1395394
27 / 19 / 15 No. 37 No. 4
C00025457 External link 512 Papaverrubin A
/ Papaverrubine A
/ N-Demethylisorheadine
No. 305
C00001911 External link 512 Rhoeadine
C019078
No. 305
C00025459 External link 512 Papaverrubine C
/ Epiporphyroxine
/ 14-Epiporphyroxine
No. 305
C00001886 External link 512 Mecambrine
/ (-)-Fugapavine
/ (-)-Mecambrine
No. 688
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00001924 External link 512 Thebaine
/ (-)-Thebaine
/ Paramorphine
CHEMBL403893
CHEMBL1318110
D013797
4 / 0 / 0 No. 1983 No. 4

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001872 C00001906 C00026092 1 / 0
O75496 Geminin Unclassified protein C00001872 C00001924 C00026092 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001872 C00001906 C00026092 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 C00025655 C00025827 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001872 C00001906 C00026092 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001872 C00001906 C00026092 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001924 C00026092 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001872 C00026092 0 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 C00026092 1 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001924 C00026092 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001872 C00026092 0 / 0
P39748 Flap endonuclease 1 Enzyme C00026092 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00026092 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00026092 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001872 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00026092 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00026092 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00026092 2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001872 3 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00026092 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026092 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001924 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001906 3 / 2
P02545 Prelamin-A/C Unclassified protein C00026092 11 / 10
P29466 Caspase-1 C14 C00026092 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00026092 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00026092 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00026092 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00026092 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00026092 0 / 0
Q99700 Ataxin-2 Unclassified protein C00026092 1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00026092 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001872 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001872 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103780 Alcohol dependence P14416
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (24)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)