Species

KNApSAcK Entry

Organism name Berberis turcomanica
Genus Berberis
Family Berberidaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Berberis
Linked NCBI taxonomy ID 22774
Linked level genus

Family

Family in NCBI taxonomy Berberidaceae
ID 41773

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (16)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00026063 External link 512 Aromoline
/ Thalicrine
/ (+)-Aromoline
CHEMBL504525
CHEMBL508781
C066341
6 / 2 / 3 No. 10 No. 4
C00001817 External link 512 Berbamine
/ d-Berbamine
/ (+)-Berbamine
CHEMBL504323
CHEMBL507540
CHEMBL1198334
C027870
4 / 3 / 4 9 / 1 No. 10 No. 4
C00001897 External link 512 Oxyacanthine
CHEMBL510022
CHEMBL509999
CHEMBL1983122
C092646
5 / 4 / 1 No. 10 No. 4
C00001861 External link 512 Glaucine
/ S-(+)-Glaucine
/ O,O-Dimethylisoboldine
CHEMBL36536
CHEMBL228082
14 / 8 / 6 No. 20 No. 4
C00027238 External link 512 Thalicmidine
/ Thaliporphine
/ (+)-Thaliporphine
/ (S)-O-Methylisoboldine
CHEMBL1394328
CHEMBL1397308
C080702
20 / 26 / 56 No. 20 No. 4
C00025827 External link 512 Corydine
/ Glaucentrin
/ (+)-Corydine
/ Glaucentrine
CHEMBL489524
CHEMBL2002847
C067341
1 / 0 / 0 No. 20 No. 4
C00026111 External link 512 Berberrubine
/ 9-Berberoline
CHEMBL203135
CHEMBL2160119
5 / 10 / 6 No. 155 No. 4
C00001819 External link 512 Thalsine
/ Majarine
/ Berberine
/ Umbellatin
CHEMBL295124
D001599
19 / 25 / 26 30 / 19 No. 155 No. 4
C00001874 External link 512 Neprotin
/ Neprotine
/ Yatrorizine
/ Jatrorrhizine
CHEMBL251055
C055785
14 / 27 / 20 1 / 0 No. 155 No. 4
C00027159 External link 512 Depiline
/ Palmatine
/ Berbericinine
/ O,O-Dimethyldemethyleneberberine
CHEMBL206106
C005413
8 / 13 / 13 8 / 0 No. 155 No. 4
C00024667 External link 512 Columbamine
/ Dehydroisocorypalmine
CHEMBL400345
C055786
1 / 0 / 1 8 / 1 No. 155 No. 4
C00001810 External link 512 Armepavine
/ (-)-Armepavine
/ (R)-(-)-Armepavine
CHEMBL451722
CHEMBL1186477
CHEMBL1186510
7 / 5 / 3 No. 345 No. 4
C00025997 External link 512 Berlambine
/ Oxyberberine
/ 8-Oxoberberine
CHEMBL11531
No. 439
C00027499 External link 512 Turcomanine
No. 1137
C00027498 External link 512 Turcomanidine
/ 1-(3,4-Dihydroxybenzyl)-6,7-dimethoxyisoquinoline
No. 1137
C00027467 External link 512 Papavarine
CHEMBL19224
121 / 66 / 52 No. 1165 No. 4

Human Protein / Gene in interactions

164 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001817 C00001819 C00001874 C00024667 C00026063 C00027159 C00027238 C00027467 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001810 C00001819 C00001861 C00027238 C00027467 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001819 C00026063 C00027159 C00027238 C00027467 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001819 C00026063 C00027159 C00027238 C00027467 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001810 C00001861 C00001874 C00027238 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001819 C00001861 C00001874 C00027238 4 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001819 C00026063 C00027159 C00027467 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001810 C00001817 C00001861 C00027238 3 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001819 C00026063 C00027159 C00027467 0 / 1
P02545 Prelamin-A/C Unclassified protein C00001874 C00027159 C00027467 11 / 10
Q16637 Survival motor neuron protein Unclassified protein C00001819 C00001874 C00027467 4 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001810 C00001874 C00027467 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001819 C00027159 C00027467 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001810 C00001874 C00026111 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001810 C00027238 C00027467 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001861 C00001874 C00001897 0 / 0
P29466 Caspase-1 C14 C00027238 C00027467 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001819 C00027238 1 / 2
O00255 Menin Unclassified protein C00001819 C00027238 2 / 5
Q9UBT6 DNA polymerase kappa Enzyme C00027238 C00027467 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001897 C00026111 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001861 C00001874 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001819 C00027467 2 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00027238 C00027467 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001810 C00001897 2 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001817 C00026063 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001861 C00001874 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001819 C00027467 3 / 2
P54750 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE_1A C00001817 C00027467 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00027467 0 / 1
P00918 Carbonic anhydrase 2 Lyase C00027467 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00027467 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00027467 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00027467 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00027467 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00027467 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00027467 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00027467 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00027467 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00027238 3 / 1
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00027467 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025827 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00027467 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00027467 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00027467 0 / 0
P54132 Bloom syndrome protein Enzyme C00027238 1 / 2
Q96LD8 Sentrin-specific protease 8 Enzyme C00001861 0 / 0
Q9BQF6 Sentrin-specific protease 7 Enzyme C00001861 0 / 0
Q9GZR1 Sentrin-specific protease 6 Enzyme C00001861 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00027467 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00027467 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00027467 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00027467 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00027467 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00027467 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00027467 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00027467 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00027467 1 / 1
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001861 0 / 0
P04062 Glucosylceramidase Enzyme C00001874 6 / 4
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00027467 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00027467 1 / 0
P06746 DNA polymerase beta Enzyme C00001874 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00027467 2 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00027467 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00027467 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001874 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00027467 0 / 0
O75496 Geminin Unclassified protein C00001861 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00027467 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00027467 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00027467 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00027467 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00027467 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00027467 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00027467 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00027467 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00027467 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00027467 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00027467 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00027467 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00027467 0 / 0
P08311 Cathepsin G S1A C00027467 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00027467 1 / 0
P03956 Interstitial collagenase M10A C00027467 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00027467 0 / 0
Q9Y233 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE_10A C00027467 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00027467 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00001819 1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00027159 0 / 0
P42574 Caspase-3 C14 C00001861 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00027467 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00027467 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00027467 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00027467 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00027467 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00027467 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00027467 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00027467 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00027467 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00027467 0 / 0
P06280 Alpha-galactosidase A Enzyme C00027238 1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00027467 2 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00027467 1 / 0
Q92793 CREB-binding protein Enzyme C00027467 1 / 1
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00027467 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00027467 0 / 0
P08246 Neutrophil elastase S1A C00027467 2 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00027238 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001861 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00027467 0 / 0
P03372 Estrogen receptor NR3A1 C00027467 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00027467 1 / 0
P22303 Acetylcholinesterase Hydrolase C00027467 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00027467 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00027467 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00027467 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00027467 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00027467 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00027467 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00027467 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00027467 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00027467 0 / 0
Q09428 ATP-binding cassette sub-family C member 8 K C00026111 5 / 3
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00027467 0 / 3
P21728 D(1A) dopamine receptor Dopamine receptor C00027467 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00027467 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00027467 2 / 2
O75164 Lysine-specific demethylase 4A Enzyme C00001897 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00027238 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00027467 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00027467 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00027467 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00027467 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00027467 0 / 0
Q14432 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE_3A C00027467 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00027467 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00027467 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00027467 0 / 1
O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE_2A C00027467 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00027467 0 / 0
O14746 Telomerase reverse transcriptase Enzyme C00001819 5 / 5
P17252 Protein kinase C alpha type Alpha C00027467 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001819 0 / 0
P40225 Thrombopoietin Unclassified protein C00027467 1 / 1
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00001819 1 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001897 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001874 1 / 1
Q13370 cGMP-inhibited 3',5'-cyclic phosphodiesterase B PDE_3B C00027467 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001819 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001819 1 / 4
Q14654 ATP-sensitive inward rectifier potassium channel 11 K C00026111 3 / 4
Q14123 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C PDE_1C C00027467 0 / 0
Q01064 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE_1B C00027467 0 / 0
P27815 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE_4A C00027467 0 / 0
Q08499 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE_4D C00027467 1 / 0
Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE_4B C00027467 0 / 0
Q08493 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE_4C C00027467 0 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00027467 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00027467 2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00027467 3 / 2
P04637 Cellular tumor antigen p53 Transcription Factor C00027238 7 / 37
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00026111 2 / 1
P55210 Caspase-7 C14 C00027238 0 / 0

46 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001817 C00001819 C00001874 C00027159
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00001817 C00001819
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00001819 C00024667
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00001819 C00024667
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001819 C00027159
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001817 C00001819
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001819 C00027159
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00001817 C00001819
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00024667
637 BID, FP497 BH3 interacting domain death agonist C00001817
3570 IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 interleukin 6 receptor C00027159
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00027159
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00001817
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00001817
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001817
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00001817
1003 CDH5, 7B4, CD144 cadherin 5, type 2 (vascular endothelium) C00024667
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00027159
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00024667
2048 EPHB2, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5 EPH receptor B2 (EC:2.7.10.1) C00024667
9500 MAGED1, DLXIN-1, NRAGE melanoma antigen family D, 1 C00024667
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00027159
64321 SOX17, VUR3 SRY (sex determining region Y)-box 17 C00024667
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00027159
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001819
581 BAX, BCL2L4 BCL2-associated X protein C00001819
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001819
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00001819
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001819
894 CCND2, KIAK0002 cyclin D2 C00001819
898 CCNE1, CCNE cyclin E1 C00001819
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00001819
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00001819
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001819
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00001819
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00001819
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001819
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00001819
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00001819
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00001819
5027 P2RX7, P2X7 purinergic receptor P2X, ligand-gated ion channel, 7 C00001819
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001819
6476 SI sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48) C00001819
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001819
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00001819
7185 TRAF1, EBI6, MGC:10353 TNF receptor-associated factor 1 C00001819

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (113)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#614613 Acrodysostosis 2, with or without hormone resistance; acrdys2 Q08499
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#609135 Aplastic anemia O14746
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
P84022
Q14191
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#606176 Diabetes mellitus, permanent neonatal; pndm Q09428
Q14654
#610374 Diabetes mellitus, transient neonatal, 2 Q09428
#610582 Diabetes mellitus, transient neonatal, 3 Q14654
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#256450 Hyperinsulinemic hypoglycemia, familial, 1; hhf1 Q09428
#601820 Hyperinsulinemic hypoglycemia, familial, 2; hhf2 Q14654
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 Q09428
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#240800 Hypoglycemia, leucine-induced; lih Q09428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180849 Rubinstein-taybi syndrome 1; rsts1 Q92793
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277700 Werner syndrome; wrn Q14191
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (108)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
P00533 (related)
P04626 (related)
P04637 (related)
H00024 Prostate cancer O14746 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) Q09428 (related)
Q14654 (related)
H00513 Transient neonatal diabetes mellitus (TNDM) Q09428 (related)
Q14654 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) Q09428 (related)
Q14654 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00409 Type II diabetes mellitus Q14654 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00504 Rubinstein-Taybi syndrome Q92793 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

21 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D015473 Leukemia, Promyelocytic, Acute C00001817
D009361 Neoplasm Invasiveness C00024667
D000647 Amnesia C00001819
D001862 Bone Resorption C00001819
D002471 Cell Transformation, Neoplastic C00001819
D003556 Cystitis C00001819
D003920 Diabetes Mellitus C00001819
D003921 Diabetes Mellitus, Experimental C00001819
D003924 Diabetes Mellitus, Type 2 C00001819
D004487 Edema C00001819
D006470 Hemorrhage C00001819
D006937 Hypercholesterolemia C00001819
D006943 Hyperglycemia C00001819
D006949 Hyperlipidemias C00001819
D006973 Hypertension C00001819
D007077 Ileal Diseases C00001819
D007333 Insulin Resistance C00001819
D007410 Intestinal Diseases C00001819
D009369 Neoplasms C00001819
D010190 Pancreatic Neoplasms C00001819
D011471 Prostatic Neoplasms C00001819