PCIDB

KNApSAcK Metabolite C00024667

Metabolite

KNApSAcK Entry

id C00024667
Name Columbamine / Dehydroisocorypalmine
CAS RN 3621-36-1
Standard InChI InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1
Standard InChI (Main Layer) InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 155

Link

ChEMBL

By standard InChI CHEMBL400345
By standard InChI Main Layer CHEMBL400345

KEGG

By LinkDB C01795

CTD

By CAS RN C055786

Species

Summary

Plant class

class name count
eudicotyledons 36
Magnoliophyta 1

Family

family name count
Ranunculaceae 14
Menispermaceae 11
Berberidaceae 10
Pieridae 1
Annonaceae 1
Papaveraceae 1

List (39)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Aconitum columbianum 157970 Ranunculaceae eudicotyledons Viridiplantae
Anamirta cocculus (L.) W.& A. 432626 Menispermaceae eudicotyledons Viridiplantae
Archangelicia flava
Berberis aemulans 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis crataegina 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis oblonga 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis poirettii 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis pruinosa 258196 Berberidaceae eudicotyledons Viridiplantae
Berberis turcomanica 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis vulgaris L. 22774 Berberidaceae eudicotyledons Viridiplantae
Burasaia australis Scott Elliot 461558 Menispermaceae eudicotyledons Viridiplantae
Burasaia congesta Decne 461558 Menispermaceae eudicotyledons Viridiplantae
Chasmanthera dependens Hochst 341014 Menispermaceae eudicotyledons Viridiplantae
Chasmanthera dependens Hochst. 341015 Menispermaceae eudicotyledons Viridiplantae
Coptis japonica Makino. 3441 Ranunculaceae eudicotyledons Viridiplantae
Coptis quinquefolia Miq. 261444 Ranunculaceae eudicotyledons Viridiplantae
Corydalis ophiocarpa Hook.f.et Thoms 3463 Papaveraceae eudicotyledons Viridiplantae
Enantia chlorantha Oliver 320276 Pieridae Metazoa
Fibraurea chloroleuca Miers 527504 Menispermaceae eudicotyledons Viridiplantae
Fibraurea chloroleuca Miore. 461587 Menispermaceae eudicotyledons Viridiplantae
Fibraurea sp. 461587 Menispermaceae eudicotyledons Viridiplantae
Fibraurea tinctoria 461588 Menispermaceae eudicotyledons Viridiplantae
Fissistigma balansae 296846 Annonaceae Magnoliophyta Viridiplantae
Isopyrum thalictroides 432643 Ranunculaceae eudicotyledons Viridiplantae
Jateorhiza palmata Miers 461596 Menispermaceae eudicotyledons Viridiplantae
Mahonia japonica 116719 Berberidaceae eudicotyledons Viridiplantae
Mahonia repens (Lindi) G.Don 22774 Berberidaceae eudicotyledons Viridiplantae
Nandina domestica 41776 Berberidaceae eudicotyledons Viridiplantae
Ranunculus serbicus 286994 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum alpinum L. 395328 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum foliolosum DC 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum javanicum Blume 327930 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum longistylum DC 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum minus L.Race B 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum minus var.hypoleucum 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum podocarpum Humb. 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum revolutum DC 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum rogosum 46968 Ranunculaceae eudicotyledons Viridiplantae
Tinospora capillipes Gagnep. 150903 Menispermaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

1 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL400345 CHEMBL942995 (1)
0 / 1

CTD interaction (9)

compound gene gene name gene description interaction interaction type form reference
pmid
C055786 1003 CDH5
7B4
CD144
cadherin 5, type 2 (vascular endothelium) columbamine results in increased expression of CDH5 mRNA increases expression
mRNA 23124089
C055786 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) columbamine results in decreased expression of CDK6 mRNA decreases expression
mRNA 23124089
C055786 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) columbamine results in decreased expression of CDK6 protein decreases expression
protein 23124089
C055786 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 23124089
C055786 2048 EPHB2
CAPB
DRT
EK5
EPHT3
ERK
Hek5
PCBC
Tyro5
EPH receptor B2 (EC:2.7.10.1) columbamine results in decreased expression of EPHB2 mRNA decreases expression
mRNA 23124089
C055786 9500 MAGED1
DLXIN-1
NRAGE
melanoma antigen family D, 1 columbamine results in decreased expression of MAGED1 mRNA decreases expression
mRNA 23124089
C055786 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) columbamine results in decreased expression of MMP2 mRNA decreases expression
mRNA 23124089
C055786 64321 SOX17
VUR3
SRY (sex determining region Y)-box 17 columbamine results in decreased expression of SOX17 mRNA decreases expression
mRNA 23124089
C055786 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 23124089

Related Disease

Diseases related to proteins in ChEMBL interactions

KEGG DISEASE (1)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D009361 C055786 Neoplasm Invasiveness therapeutic
23124089