PCIDB

Fibraurea tinctoria

Species

KNApSAcK Entry

Organism name Fibraurea tinctoria
Genus Fibraurea
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Fibraurea tinctoria
Linked NCBI taxonomy ID 461588
Linked level species

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00039714 External link 512 Makisterone A
CHEMBL255034
1 / 0 / 1 No. 58 No. 11
C00024667 External link 512 Columbamine
/ Dehydroisocorypalmine
CHEMBL400345
C055786
1 / 0 / 1 8 / 1 No. 155 No. 4
C00026048 External link 512 Stepharanin
/ Stepharanine
CHEMBL251229
1 / 0 / 1 No. 155 No. 4
C00027159 External link 512 Depiline
/ Palmatine
/ Berbericinine
/ O,O-Dimethyldemethyleneberberine
CHEMBL206106
C005413
8 / 13 / 13 8 / 0 No. 155 No. 4
C00001874 External link 512 Neprotin
/ Neprotine
/ Yatrorizine
/ Jatrorrhizine
CHEMBL251055
C055785
14 / 27 / 20 1 / 0 No. 155 No. 4
C00039211 External link 512 Fibrauretin A
/ (+)-Fibrauretin A
CHEMBL398472
1 / 0 / 1 No. 1330 No. 43
C00039113 External link 512 epi-12-Palmatoside G
/ (+)-epi-12-Palmatoside G
CHEMBL251672
1 / 0 / 1 No. 1353
C00039212 External link 512 Fibrauretinoside A
No. 1450
C00039210 External link 512 Fibleucinoside
CHEMBL399973
1 / 0 / 1 No. 1450
C00039213 External link 512 Fibraurinoside
CHEMBL399731
1 / 0 / 1 No. 1450
C00039130 External link 512 epi-Fibrauretinoside A
/ (+)-epi-Fibrauretinoside A
No. 1450

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001874 C00024667 C00026048 C00027159 C00039113 C00039210 C00039211 C00039213 C00039714 0 / 1
P02545 Prelamin-A/C Unclassified protein C00001874 C00027159 11 / 10
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00027159 0 / 0
P04062 Glucosylceramidase Enzyme C00001874 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00001874 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00027159 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00027159 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001874 1 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00027159 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001874 0 / 0
P06746 DNA polymerase beta Enzyme C00001874 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00027159 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00027159 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00001874 4 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001874 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001874 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001874 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001874 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001874 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001874 0 / 0

16 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001874 C00027159
1003 CDH5, 7B4, CD144 cadherin 5, type 2 (vascular endothelium) C00024667
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00027159
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00027159
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00027159
3570 IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 interleukin 6 receptor C00027159
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00027159
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00027159
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00027159
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00024667
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00024667
2048 EPHB2, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5 EPH receptor B2 (EC:2.7.10.1) C00024667
9500 MAGED1, DLXIN-1, NRAGE melanoma antigen family D, 1 C00024667
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00024667
64321 SOX17, VUR3 SRY (sex determining region Y)-box 17 C00024667
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00024667

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (22)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009361 Neoplasm Invasiveness C00024667