PCIDB

KNApSAcK Metabolite C00001874

Metabolite

KNApSAcK Entry

id C00001874
Name Neprotin / Neprotine / Yatrorizine / Jatrorrhizine
CAS RN 3621-38-3
Standard InChI InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1
Standard InChI (Main Layer) InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 155

Link

ChEMBL

By standard InChI CHEMBL251055
By standard InChI Main Layer CHEMBL251055

KEGG

By LinkDB C09553

CTD

By CAS RN C055785

Species

Summary

Plant class

class name count
eudicotyledons 23
Magnoliophyta 2
rosids 1

Family

family name count
Berberidaceae 14
Menispermaceae 4
Ranunculaceae 4
Pieridae 1
Magnoliaceae 1
Papaveraceae 1
Annonaceae 1
Rutaceae 1

List (29)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acangelisia gusanlung 3455 Menispermaceae eudicotyledons Viridiplantae
Archangelicia flava
Berberis aemulans 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis cratagina 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis heterobotrys 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis julianae 258178 Berberidaceae eudicotyledons Viridiplantae
Berberis poirettii 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis pruinosa 258196 Berberidaceae eudicotyledons Viridiplantae
Berberis spp. 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis turcomanica 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis vulgaris 258209 Berberidaceae eudicotyledons Viridiplantae
Chelidonum majus
Coptis japonica 3442 Ranunculaceae eudicotyledons Viridiplantae
Enantia chlorantha 320276 Pieridae Metazoa
Fibraurea chloroleuca 527504 Menispermaceae eudicotyledons Viridiplantae
Fibraurea tinctoria 461588 Menispermaceae eudicotyledons Viridiplantae
Glaucium arabicum 56852 Papaveraceae eudicotyledons Viridiplantae
Jateorhiza palmata 461596 Menispermaceae eudicotyledons Viridiplantae
Mahonia aquifolium 203270 Berberidaceae eudicotyledons Viridiplantae
Mahonia japonica 116719 Berberidaceae eudicotyledons Viridiplantae
Mahonia nepalensis 22774 Berberidaceae eudicotyledons Viridiplantae
Mahonia spp. 22774 Berberidaceae eudicotyledons Viridiplantae
Michelia spp. 13611 Magnoliaceae Magnoliophyta Viridiplantae
Nandina domestica 41776 Berberidaceae eudicotyledons Viridiplantae
Thalictrum honanense 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum minus 476039 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum spp. 46968 Ranunculaceae eudicotyledons Viridiplantae
Xylopia parviflora 992813 Annonaceae Magnoliophyta Viridiplantae
Zanthoxylum chaylbeum 67937 Rutaceae rosids Viridiplantae

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein CHEMBL251055 CHEMBL1613842 (1)
4 / 2
P06746 DNA polymerase beta Enzyme CHEMBL251055 CHEMBL1614079 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL251055 CHEMBL1613818 (1)
6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL251055 CHEMBL1614175 (1)
1 / 1
P02545 Prelamin-A/C Unclassified protein CHEMBL251055 CHEMBL1614544 (1)
11 / 10
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL251055 CHEMBL1614166 (1)
1 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL251055 CHEMBL1794486 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL251055 CHEMBL942995 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL251055 CHEMBL1794483 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL251055 CHEMBL1614421 (1)
4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL251055 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL251055 CHEMBL1738442 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL251055 CHEMBL2114738 (1)
0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein CHEMBL251055 CHEMBL2354285 (1)
0 / 0

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
C055785 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 jatrorrhizine binds to BIRC5 promoter affects binding
promoter 17968851

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (20)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)