Species

KNApSAcK Entry

Organism name Enantia chlorantha
Genus Enantia
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Enantia
Linked NCBI taxonomy ID 320276
Linked level genus

Family

Family in NCBI taxonomy Pieridae
ID 7114

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Metazoa
ID 33208

Plant class

Plant class
ID

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00029094 External link 512 Xylopinine
/ Tetrahydropseudopalmatine
CHEMBL465824
CHEMBL2357282
1 / 0 / 0 No. 37 No. 4
C00026149 External link 512 Corypalmine
/ Tetrahydrojatrorrhizine
CHEMBL2334885
CHEMBL2334886
4 / 3 / 0 No. 37 No. 4
C00026150 External link 512 Tetrahydropalmatine
/ dl-Tetrahydropalmatine
/ (+/-)-Tetrahydropalmatine
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025632 External link 512 Isocorypalmine
/ (-)-Isocorypalmine
/ Tetrahydrocolumbamine
/ O10-Methylstepholidine
CHEMBL2334891
CHEMBL2334892
4 / 3 / 0 No. 37 No. 4
C00025890 External link 512 Liridine
/ Homomoschatoline
/ O-Methylmoschatoline
/ O-Methylisomoschatoline
CHEMBL227533
No. 74
C00001878 External link 512 Liriodenine
/ Oxoushinsunine
/ Spermatheridine
CHEMBL37736
C026980
5 / 3 / 1 No. 74
C00025935 External link 512 Lysicamine
/ Oxonuciferine
CHEMBL510090
C069090
No. 74
C00026143 External link 512 Govanine
/ Pseudocolumbamine
CHEMBL1197451
No. 155 No. 4
C00025342 External link 512 Pseudopalmatine
/ 5,6-Dihydro-8-demethylcoralyne
CHEMBL376300
No. 155 No. 4
C00027159 External link 512 Depiline
/ Palmatine
/ Berbericinine
/ O,O-Dimethyldemethyleneberberine
CHEMBL206106
C005413
8 / 13 / 13 8 / 0 No. 155 No. 4
C00001874 External link 512 Neprotin
/ Neprotine
/ Yatrorizine
/ Jatrorrhizine
CHEMBL251055
C055785
14 / 27 / 20 1 / 0 No. 155 No. 4

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001874 C00026150 C00027159 0 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025632 C00026149 C00026150 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00025632 C00026149 C00026150 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025632 C00026149 C00026150 2 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025632 C00026149 C00026150 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001874 C00029094 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001874 C00027159 11 / 10
P39748 Flap endonuclease 1 Enzyme C00001874 0 / 0
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001878 0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001878 1 / 0
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001878 1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001878 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001874 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001874 1 / 1
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001878 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00027159 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00027159 0 / 1
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00026150 1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00027159 0 / 0
P13726 Tissue factor Membrane receptor C00026150 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00027159 0 / 0
P03372 Estrogen receptor NR3A1 C00026150 1 / 1
P04062 Glucosylceramidase Enzyme C00001874 6 / 4
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00027159 1 / 1
P06746 DNA polymerase beta Enzyme C00001874 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001874 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001874 4 / 3
Q16637 Survival motor neuron protein Unclassified protein C00001874 4 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001874 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001874 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001874 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00027159 1 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001874 C00027159
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00027159
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00027159
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00027159
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00027159
3570 IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 interleukin 6 receptor C00027159
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00027159
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00027159

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (37)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (24)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)