| Organism name | Fibraurea chloroleuca | 
|---|---|
| Genus | Fibraurea | 
| Family | Menispermaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Fibraurea chloroleuca | 
|---|---|
| Linked NCBI taxonomy ID | 527504 | 
| Linked level | species | 
| Family in NCBI taxonomy | Menispermaceae | 
|---|---|
| ID | 3455 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | eudicotyledons | 
|---|---|
| ID | 71240 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00001874   | Neprotin / Neprotine / Yatrorizine / Jatrorrhizine | CHEMBL251055 | C055785 | 14 / 27 / 20 | 1 / 0 | No. 155 | No. 4 |   | 
| C00026143   | Govanine / Pseudocolumbamine | CHEMBL1197451 | No. 155 | No. 4 |   | |||
| C00027159   | Depiline / Palmatine / Berbericinine / O,O-Dimethyldemethyleneberberine | CHEMBL206106 | C005413 | 8 / 13 / 13 | 8 / 0 | No. 155 | No. 4 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| P02545 | Prelamin-A/C | Unclassified protein | C00001874 C00027159 | 11 / 10 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001874 C00027159 | 0 / 1 | 
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00027159 | 0 / 0 | 
| P04062 | Glucosylceramidase | Enzyme | C00001874 | 6 / 4 | 
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001874 | 1 / 1 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00027159 | 1 / 0 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00027159 | 0 / 1 | 
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001874 | 1 / 0 | 
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00027159 | 0 / 0 | 
| P39748 | Flap endonuclease 1 | Enzyme | C00001874 | 0 / 0 | 
| P06746 | DNA polymerase beta | Enzyme | C00001874 | 0 / 0 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00027159 | 0 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00027159 | 1 / 1 | 
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001874 | 4 / 1 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001874 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001874 | 4 / 3 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001874 | 0 / 0 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001874 | 0 / 0 | 
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001874 | 0 / 0 | 
| P43351 | DNA repair protein RAD52 homolog | Unclassified protein | C00001874 | 0 / 0 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 | C00001874
                          C00027159 | 
| 6352 | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP | chemokine (C-C motif) ligand 5 | C00027159 | 
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 | C00027159 | 
| 6351 | CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 | chemokine (C-C motif) ligand 4 | C00027159 | 
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 | C00027159 | 
| 3570 | IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 | interleukin 6 receptor | C00027159 | 
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 | C00027159 | 
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A | C00027159 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #608013 | Gaucher disease, perinatal lethal | P04062 | 
| #230800 | Gaucher disease, type i | P04062 | 
| #230900 | Gaucher disease, type ii | P04062 | 
| #231000 | Gaucher disease, type iii | P04062 | 
| #231005 | Gaucher disease, type iiic | P04062 | 
| #232300 | Glycogen storage disease ii | P10253 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #160900 | Myotonic dystrophy 1; dm1 | Q9NR56 | 
| #168600 | Parkinson disease, late-onset; pd | P04062 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #172700 | Pick disease of brain | P10636 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #253300 | Spinal muscular atrophy, type i; sma1 | Q16637 | 
| #253550 | Spinal muscular atrophy, type ii; sma2 | Q16637 | 
| #253400 | Spinal muscular atrophy, type iii; sma3 | Q16637 | 
| #271150 | Spinal muscular atrophy, type iv; sma4 | Q16637 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00066 | Lewy body dementia (LBD) | P04062
                            (related) | 
| H00126 | Gaucher disease | P04062
                            (related) | 
| H00426 | Defects in the degradation of ganglioside | P04062
                            (related) | 
| H00810 | Progressive myoclonic epilepsy (PME) | P04062
                            (related) | 
| H00036 | Osteosarcoma | P08684
                            (marker) | 
| H00069 | Glycogen storage diseases (GSD) | P10253
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00455 | Spinal muscular atrophy (SMA) | Q16637
                            (related) |