PCIDB

Jateorhiza palmata

Species

KNApSAcK Entry

Organism name Jateorhiza palmata
Genus Jateorhiza
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Jateorhiza
Linked NCBI taxonomy ID 461596
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Natural Activity

List (13)

Species Activity
Jateorhiza palmata (Lam.) Miers Anthelminthic
Jateorhiza palmata (Lam.) Miers Antiseptic
Jateorhiza palmata (Lam.) Miers Aperitif
Jateorhiza palmata (Lam.) Miers Bitter
Jateorhiza palmata (Lam.) Miers CNS-Paralytic
Jateorhiza palmata (Lam.) Miers Emetic
Jateorhiza palmata (Lam.) Miers Fungicide
Jateorhiza palmata (Lam.) Miers Gastrotonic
Jateorhiza palmata (Lam.) Miers Hypotensive
Jateorhiza palmata (Lam.) Miers Laxative
Jateorhiza palmata (Lam.) Miers Narcotic
Jateorhiza palmata (Lam.) Miers Stomachic
Jateorhiza palmata (Lam.) Miers Tonic

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001874 External link 512 Neprotin
/ Neprotine
/ Yatrorizine
/ Jatrorrhizine
CHEMBL251055
C055785
14 / 27 / 20 1 / 0 No. 155 No. 4
C00001898 External link 512 Palmatine
CHEMBL206106
C005413
8 / 13 / 13 8 / 0 No. 155 No. 4
C00027159 External link 512 Depiline
/ Palmatine
/ Berbericinine
/ O,O-Dimethyldemethyleneberberine
CHEMBL206106
C005413
8 / 13 / 13 8 / 0 No. 155 No. 4
C00003413 External link 512 Chasmanthin
CHEMBL458613
No. 1330 No. 43
C00003463 External link 512 Palmarin
CHEMBL458613
C062507
No. 1330 No. 43
C00003417 External link 512 Columbin
CHEMBL1417543
C062514
3 / 5 / 4 No. 2453 No. 43

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001874 C00001898 C00027159 0 / 1
P02545 Prelamin-A/C Unclassified protein C00001874 C00001898 C00027159 11 / 10
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001898 C00027159 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001898 C00027159 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001898 C00027159 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001874 C00003417 4 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001898 C00027159 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001898 C00027159 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001898 C00027159 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001874 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001874 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001874 1 / 1
P04062 Glucosylceramidase Enzyme C00001874 6 / 4
P06746 DNA polymerase beta Enzyme C00001874 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001874 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00003417 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001874 4 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001874 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001874 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003417 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001874 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001874 0 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001874 C00001898 C00027159
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00001898 C00027159
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00001898 C00027159
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00001898 C00027159
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001898 C00027159
3570 IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 interleukin 6 receptor C00001898 C00027159
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001898 C00027159
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00001898 C00027159

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (30)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (23)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)