KCF-S cluster No. 58 (68 metabolites)

Corresponding Phytochemical cluster No. 11

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (68)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	59
eudicotyledons	27
Spermatophyta	11
Euphyllophyta	8

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Cumulative family count

class name	count
Asteraceae	39
Lamiaceae	20
Amaranthaceae	13
Zoanthidae	10
Taxaceae	7
Polyporaceae	7
Caryophyllaceae	6
Tapinellaceae	6
Menispermaceae	6
Podocarpaceae	4
Polypodiaceae	4
Dryopteridaceae	2
Ranunculaceae	2
Agelasidae	1
Blechnaceae	1
Dennstaedtiaceae	1

KEGG BRITE br08003

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Categories (3)

br08003 Category	# of metabolite
Stigmastane	2
Cholestane	7
Ergostane	1

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metabolites link (11)

br08003 Category	KEGG ID	KNApSAcK ID
Stigmastane	C08810	C00003642
Cholestane	C08811	C00003643
Stigmastane	C08816	C00003649
Cholestane	C00477	C00003651
Cholestane	C02633	C00003654
Cholestane	C08819	C00003655
Ergostane	C08829	C00003660
Cholestane	C08834	C00003666
Cholestane	C08835	C00003667
Cholestane	C08838	C00003670
Cholestane	C00477	C00048314

Metabolite list (68)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003642	Ajugalactone	CHEMBL2087160		1 / 1 / 0
C00003643	Ajugasterone C	CHEMBL477336		1 / 1 / 0
C00003649	Cyasterone	CHEMBL494249 CHEMBL1736717	C002082	2 / 1 / 0
C00003651	Ecdysone	CHEMBL549300 CHEMBL1456897	D004440	4 / 4 / 7
C00003654	Ecdysterone / beta-Ecdysterone / 20-Hydroxyecdysone	CHEMBL224128 CHEMBL490151 CHEMBL477132 CHEMBL1707235 CHEMBL2087148 CHEMBL2087156 CHEMBL2087157 CHEMBL2354392	D004441	6 / 2 / 1
C00003655	Inokosterone	CHEMBL564971 CHEMBL1967672	C100084
C00003660	Makisterone B
C00003666	Polypodine B	CHEMBL522181 CHEMBL502028 CHEMBL1567145		1 / 1 / 0
C00003667	Ponasterone A	CHEMBL549789 CHEMBL1881624	C008999	3 / 2 / 0	2 / 0
C00003670	Pterosterone	CHEMBL2087151		1 / 1 / 0
C00028006	Canescensterone / (+)-Canescensterone
C00031585	Ajugalide E
C00031896	Isocyasterone	CHEMBL494249 CHEMBL1736717		2 / 1 / 0
C00033543	20-Hydroxyecdysone	CHEMBL224128 CHEMBL490151 CHEMBL477132 CHEMBL1707235 CHEMBL2087148 CHEMBL2087156 CHEMBL2087157 CHEMBL2354392		6 / 2 / 1
C00036472	24-epi-Pterosterone / (+)-24-epi-Pterosterone	CHEMBL2087151		1 / 1 / 0
C00038226	2-Deoxy-5,20,26-trihydroxyecdysone
C00039714	Makisterone A	CHEMBL255034		1 / 0 / 1
C00040785	1-epi-Integristerone A	CHEMBL2087144		1 / 1 / 0
C00040811	2-Dehydro-3-epi-20-hydroxyecdysone / (+)-2-Dehydro-3-epi-20-hydroxyecdysone
C00041048	Malacosterone
C00041077	Panuosterone
C00041079	Paxillosterone
C00041169	Taxisterone	CHEMBL2087145		1 / 1 / 0
C00041214	Turkesterone	CHEMBL2087140	C017787	1 / 1 / 0
C00043834	Polyporusterone A / (+)-Polyporusterone A	CHEMBL404770
C00043835	Polyporusterone B / (+)-Polyporusterone B	CHEMBL260669
C00043836	Polyporusterone C	CHEMBL410507
C00043837	Polyporusterone D	CHEMBL479518
C00043838	Polyporusterone E	CHEMBL479334
C00043839	Polyporusterone F	CHEMBL479520
C00043840	Polyporusterone G	CHEMBL409505
C00045167	20-Hydroxyecdysone 2-acetate
C00045173	2-Deoxy-20-hydroxyecdysone	CHEMBL2087143		1 / 1 / 0
C00045323	Integristerone A 25-acetate
C00045448	Viticosterone E / (+)-Viticosterone E
C00045464	Zoanthusterone
C00048241	(24Z)-29-Hydroxy-24(28)-dehydromakisterone C / (+)-(24Z)-29-Hydroxy-24(28)-dehydromakisterone C
C00048253	15-Hydroxyponasterone A / (+)-15-Hydroxyponasterone A
C00048256	1beta-Hydroxymakisterone C / (+)-1beta-Hydroxymakisterone C
C00048265	20-Hydroxyecdysone 2-acetate
C00048266	22-Deoxy-28-hydroxymakisterone C / (+)-22-Deoxy-28-hydroxymakisterone C
C00048267	22-Oxo-20-hydroxyecdysone
C00048269	24(28)-Dehydroamarasterone B
C00048270	24(28)-Dehydromakisterone A
C00048271	24-epi-Makisterone A	CHEMBL255034		1 / 0 / 1
C00048272	26-Hydroxymakisterone C / (+)-26-Hydroxymakisterone C
C00048273	2-Deoxyecdysterone	CHEMBL2087143		1 / 1 / 0
C00048286	3-epi-20-Hydroxyecdysone	CHEMBL224128 CHEMBL490151 CHEMBL477132 CHEMBL1707235 CHEMBL2087148 CHEMBL2087156 CHEMBL2087157 CHEMBL2354392		6 / 2 / 1
C00048292	5alpha-20-Hydroxyecdysone / (+)-5alpha-20-Hydroxyecdysone	CHEMBL224128 CHEMBL490151 CHEMBL477132 CHEMBL1707235 CHEMBL2087148 CHEMBL2087156 CHEMBL2087157 CHEMBL2354392		6 / 2 / 1
C00048305	Achyranthesterone A / (+)-Achyranthesterone A
C00048314	alpha-Ecdysone	CHEMBL549300 CHEMBL1456897	D004440	4 / 4 / 7
C00048318	Amarasterone A
C00048346	Carthamoleusterone / (+)-Carthamoleusterone
C00048347	Carthamosterone
C00048348	Carthamosterone A
C00048349	Carthamosterone B
C00048429	Integristerone A	CHEMBL2087144		1 / 1 / 0
C00048431	Integristerone B
C00048439	Isovitexirone
C00048469	Lesterone	CHEMBL2087140		1 / 1 / 0
C00048470	Leuzeasterone / (+)-Leuzeasterone
C00048475	Makisterone C	CHEMBL2087159		1 / 1 / 0
C00048521	Rapisterone
C00048522	Rapisterone B
C00048523	Rapisterone D	CHEMBL522181 CHEMBL502028 CHEMBL1567145		1 / 1 / 0
C00049632	Decumbesterone A	CHEMBL495061
C00049773	22-epi-20-Hydroxyecdysone	CHEMBL224128 CHEMBL490151 CHEMBL477132 CHEMBL1707235 CHEMBL2087148 CHEMBL2087156 CHEMBL2087157 CHEMBL2354392		6 / 2 / 1
C00049793	Gerardiasterone

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08183	Multidrug resistance protein 1	drug	C00003642 C00003643 C00003649 C00003651 C00003654 C00003666 C00003667 C00003670 C00031896 C00033543 C00036472 C00040785 C00041169 C00041214 C00045173 C00048273 C00048286 C00048292 C00048314 C00048429 C00048469 C00048475 C00048523 C00049773	1 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003649 C00003654 C00031896 C00033543 C00048286 C00048292 C00049773	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00003654 C00033543 C00048286 C00048292 C00049773	0 / 0
O75496	Geminin	Unclassified protein	C00003654 C00033543 C00048286 C00048292 C00049773	0 / 0
O00167	Eyes absent homolog 2	Enzyme	C00003654 C00033543 C00048286 C00048292 C00049773	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00003654 C00033543 C00048286 C00048292 C00049773	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00003651 C00003667 C00048314	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00039714 C00048271	0 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003651 C00048314	1 / 2
O00255	Menin	Unclassified protein	C00003651 C00048314	2 / 5
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003667	1 / 0

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
2272	FHIT, AP3Aase, FRA3B	fragile histidine triad (EC:3.6.1.29)	C00003667
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00003667

Related Diseases

Diseases related to proteins in ChEMBL interactions