Species

KNApSAcK Entry

Organism name Fissistigma balansae
Genus Fissistigma
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Fissistigma
Linked NCBI taxonomy ID 296846
Linked level genus

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025241 External link 512 Kikemanin
/ Kikemanine
/ Corydalmine
/ Schefferine
/ (-)-Kikemanine
/ (-)-Corydalmine
CHEMBL448891
CHEMBL1209608
CHEMBL2334894
C058198
5 / 3 / 0 No. 37 No. 4
C00027489 External link 512 Thaipetaline
/ (-)-Thaipetaline
/ 10-O-Demethylthaicanine
No. 37 No. 4
C00027282 External link 512 Aristolactam BIII
/ Aristololactam B III
CHEMBL390715
No. 125
C00027470 External link 512 Piperolactam A
CHEMBL387864
C457227
No. 125
C00027121 External link 512 Aristolactam AII
/ Aristololactam A II
CHEMBL390368
No. 125
C00027122 External link 512 Aristolactam AIIIa
CHEMBL388956
5 / 1 / 3 No. 125
C00025791 External link 512 Cepharanone B
/ Aristolactam BII
/ Aristololactam B II
CHEMBL226772
C064674
No. 125
C00027471 External link 512 Piperolactam C
/ O-Methylpiperolactam B
/ Piperolactam B methyl ether
CHEMBL250441
No. 125
C00027350 External link 512 Enterocarpam I
CHEMBL519867
No. 125
C00027484 External link 512 Stigmalactam
CHEMBL486789
No. 125
C00027371 External link 512 Goniothalactam
CHEMBL228081
No. 125
C00027434 External link 512 Norcepharadione B
CHEMBL227414
C457229
No. 125
C00027284 External link 512 Goniopetaline
/ Goniopedaline
/ Aristolactam FII
No. 125
C00026126 External link 512 Dehydrodiscretamine
No. 155 No. 4
C00024667 External link 512 Columbamine
/ Dehydroisocorypalmine
CHEMBL400345
C055786
1 / 0 / 1 8 / 1 No. 155 No. 4
C00034515 External link 512 Fissisaine
No. 155 No. 4
C00027436 External link 512 Norfissilandione
/ 1,2-(Methylenedioxy)-9-methoxy-8,11-dioxo-6a,7-dehydroaporphine
No. 2415
C00027365 External link 512 Fissilandione
No. 2415

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00025241 0 / 0
O14965 Aurora kinase A Aur C00027122 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00027122 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00027122 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025241 2 / 0
Q96GD4 Aurora kinase B Aur C00027122 0 / 0
P13726 Tissue factor Membrane receptor C00025241 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025241 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00024667 0 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025241 1 / 0
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00027122 1 / 3

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1003 CDH5, 7B4, CD144 cadherin 5, type 2 (vascular endothelium) C00024667
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00024667
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00024667
2048 EPHB2, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5 EPH receptor B2 (EC:2.7.10.1) C00024667
9500 MAGED1, DLXIN-1, NRAGE melanoma antigen family D, 1 C00024667
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00024667
64321 SOX17, VUR3 SRY (sex determining region Y)-box 17 C00024667
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00024667

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908

KEGG DISEASE (4)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00030 Cervical cancer P11802 (related)
H00038 Malignant melanoma P11802 (related)
H00042 Glioma P11802 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009361 Neoplasm Invasiveness C00024667