Isopyrum thalictroides

• Index
• Plant Species
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Isopyrum thalictroides
Genus	Isopyrum
Family	Ranunculaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Isopyrum thalictroides
Linked NCBI taxonomy ID	432643
Linked level	species

Family

Family in NCBI taxonomy	Ranunculaceae
ID	3440

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	eudicotyledons
ID	71240

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005514	Rhamnetin 3-rutinoside					No. 1	No. 15
C00027396	Isothalmidine / (+)-Isothalmidine					No. 10	No. 4
C00001872	Isocorydine / (+)-Isocorydine / L-(+)-Isocorydine / (S)-(+)-Isocorydine	CHEMBL489525 CHEMBL1376826		14 / 7 / 10		No. 20	No. 4
C00039457	Isothalicrine / (+)-Isothalicrine					No. 89	No. 4
C00039459	Isothalirine					No. 89	No. 4
C00027159	Depiline / Palmatine / Berbericinine / O,O-Dimethyldemethyleneberberine	CHEMBL206106	C005413	8 / 13 / 13	8 / 0	No. 155	No. 4
C00024667	Columbamine / Dehydroisocorypalmine	CHEMBL400345	C055786	1 / 0 / 1	8 / 1	No. 155	No. 4
C00026132	Isocoptisine / Pseudocoptisine					No. 155	No. 4
C00001910	Reticuline / (+)-Reticuline	CHEMBL235212 CHEMBL401501 CHEMBL464734	C003298	1 / 0 / 0		No. 345	No. 4
C00027393	Isopythaldine					No. 2328
C00027392	Isopyruthaldine					No. 2328
C00027146	Isothaliphine / (-)-Isothaliphine					No. 2328
C00039458	Isothalictrine					No. 2328
C00027168	Thaliphine					No. 2328

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001872 C00024667 C00027159	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001872 C00027159	1 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001872 C00027159	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001872 C00027159	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001872 C00027159	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001872	3 / 3
O75496	Geminin	Unclassified protein	C00001872	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00027159	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001872	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00027159	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00001910	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00001872	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00027159	11 / 10
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001872	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00001872	1 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001872	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001872	1 / 4
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001872	0 / 0

16 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00027159
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00027159
6348	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3	chemokine (C-C motif) ligand 3	C00027159
6351	CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4	chemokine (C-C motif) ligand 4	C00027159
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00027159
3570	IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80	interleukin 6 receptor	C00027159
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00027159
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00027159
1003	CDH5, 7B4, CD144	cadherin 5, type 2 (vascular endothelium)	C00024667
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00024667
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00024667
2048	EPHB2, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5	EPH receptor B2 (EC:2.7.10.1)	C00024667
9500	MAGED1, DLXIN-1, NRAGE	melanoma antigen family D, 1	C00024667
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00024667
64321	SOX17, VUR3	SRY (sex determining region Y)-box 17	C00024667
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00024667

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions