KCF-S cluster No. 89 (52 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (52)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
eudicotyledons	65
Magnoliophyta	11

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Cumulative family count

class name	count
Ranunculaceae	31
Menispermaceae	22
Berberidaceae	11
Hernandiaceae	7
Annonaceae	2
Lauraceae	1
Aristolochiaceae	1
Nelumbonaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	6

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metabolites link (8)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C09323	C00001791
Isoquinoline alkaloids	C09419	C00001845
Isoquinoline alkaloids	C09441	C00001858
Isoquinoline alkaloids	C09655	C00001920
Isoquinoline alkaloids	C05177	C00025262
Isoquinoline alkaloids	C06511	C00025616
Isoquinoline alkaloids	C05177	C00027522
Isoquinoline alkaloids	C09419	C00028131

Metabolite list (52)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001791	Adiantifoline	CHEMBL2002665	C087813
C00001845	Dauricine	CHEMBL442717 CHEMBL1721004 CHEMBL1995008	C035934	2 / 2 / 2	1 / 2
C00001858	Fetidine
C00001920	Thalicarpine / (+)-Thalicarpine	CHEMBL507100	C073328
C00025262	Berbamunine / (+)-Berbamunine	CHEMBL1187468
C00025606	Daurisoline / (-)-Daurisoline / (R,R)-Daurisoline	CHEMBL2216904	C023968	1 / 2 / 2
C00025611	Grisabine / (-)-Grisabine / 1-Epicuspidaline	CHEMBL1186148
C00025616	Dauriciline / Guattegaumerine / 1'betaH-Berbamunine / N,N'-Dimethyllindoldhamine / (-)-N,N'-Dimethyllindoldhamine	CHEMBL1187468	C052054
C00025836	Dauricinoline
C00025837	Dauricoline
C00025839	Daurinoline
C00025880	Magnolin / Grisabutine	CHEMBL1187468
C00025930	Lindoldhamine / (+)-Lindoldhamine	CHEMBL1375576		9 / 8 / 11
C00026053	Sutchueneneonine / (+)-Sutchueneneonine
C00027491	Thalibealine / (-)-Thalibealine
C00027493	Thalmelatidine		C087814
C00027501	Vateamine 2'beta-N-oxide
C00027522	Berbamunine / (+)-Berbamunine	CHEMBL1187468
C00027552	Isopyruthaline / (+)-Isopyruthaline
C00027553	Isopythaline
C00027562	Malekulatine / (+)-Malekulatine	CHEMBL504018
C00027612	(-)-Temuconine
C00028041	(+)-O-Methylchenabinol / Chenabinol methyl ether / (+)-Chenabinol methyl ether
C00028061	Cissampentine
C00028131	Dauricine	CHEMBL442717 CHEMBL1721004 CHEMBL1995008	C035934	2 / 2 / 2	1 / 2
C00028257	Espinine
C00028341	Herveline A
C00028342	Herveline B
C00028343	Herveline C
C00028473	Liensinine		C080095
C00028677	Neosutchuenenine
C00028790	Pakistanine / (+)-Pakistanine		C008754
C00029065	Sutchuenenine
C00029101	Thalictrogamine
C00029103	Thalifaberidine	CHEMBL446572	C091306
C00029104	Thalifaramine
C00029105	Thalifarazine
C00029106	Thalifaronine
C00029111	Thalipine
C00029113	Thalmelatine / (+)-Thalmelatine
C00029236	Waziristanine
C00039457	Isothalicrine / (+)-Isothalicrine
C00039459	Isothalirine
C00040813	3',5'-Dihydroxythalifaboramine / (+)-3',5'-Dihydroxythalifaboramine
C00040819	3-Hydroxy-6'-desmethyl-9-O-methylthalifaboramine	CHEMBL1171064
C00040820	3-Hydroxy-6'-desmethylthalifaboramine / (+)-3-Hydroxy-6'-desmethylthalifaboramine
C00040824	3-Hydroxythalifaboramine / (+)-3-Hydroxythalifaboramine	CHEMBL1171065
C00040840	5'-Hydroxythalifaboramine / (+)-5'-Hydroxythalifaboramine
C00041208	Thaligrisine / (+)-Thaligrisine	CHEMBL1186148
C00049607	3-Methoxyfaurithaline / (+)-3-Methoxyfaurithaline
C00049637	Fauripavine / (+)-Fauripavine
C00049638	Faurithaline / (+)-Faurithaline

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00001845 C00025606 C00028131	2 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001845 C00028131	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00025930	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00025930	1 / 2
P14618	Pyruvate kinase PKM	Enzyme	C00025930	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00025930	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00025930	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00025930	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00025930	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00025930	1 / 1
O00255	Menin	Unclassified protein	C00025930	2 / 5

1 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00001845 C00028131

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions