Species

KNApSAcK Entry

Organism name Chasmanthera dependens Hochst.
Genus Chasmanthera
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Chasmanthera dependens
Linked NCBI taxonomy ID 341015
Linked level species

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00026150 External link 512 Tetrahydropalmatine
/ dl-Tetrahydropalmatine
/ (+/-)-Tetrahydropalmatine
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00024667 External link 512 Columbamine
/ Dehydroisocorypalmine
CHEMBL400345
C055786
1 / 0 / 1 8 / 1 No. 155 No. 4

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00024667 C00026150 0 / 1
P03372 Estrogen receptor NR3A1 C00026150 1 / 1
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00026150 1 / 0
P13726 Tissue factor Membrane receptor C00026150 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00026150 2 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026150 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00026150 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00026150 1 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1003 CDH5, 7B4, CD144 cadherin 5, type 2 (vascular endothelium) C00024667
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00024667
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00024667
2048 EPHB2, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5 EPH receptor B2 (EC:2.7.10.1) C00024667
9500 MAGED1, DLXIN-1, NRAGE melanoma antigen family D, 1 C00024667
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00024667
64321 SOX17, VUR3 SRY (sex determining region Y)-box 17 C00024667
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00024667

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#615363 Estrogen resistance; estrr P03372
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908

KEGG DISEASE (2)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009361 Neoplasm Invasiveness C00024667