Species

KNApSAcK Entry

Organism name Fibraurea chloroleuca Miore.
Genus Fibraurea
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Fibraurea
Linked NCBI taxonomy ID 461587
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00024667 External link 512 Columbamine
/ Dehydroisocorypalmine
CHEMBL400345
C055786
1 / 0 / 1 8 / 1 No. 155 No. 4
C00026111 External link 512 Berberrubine
/ 9-Berberoline
CHEMBL203135
CHEMBL2160119
5 / 10 / 6 No. 155 No. 4
C00026127 External link 512 Dehydrodiscretine
/ Pseudojatrorrhizine
CHEMBL220527
No. 155 No. 4

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00026111 1 / 1
Q09428 ATP-binding cassette sub-family C member 8 K C00026111 5 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00024667 0 / 1
Q14654 ATP-sensitive inward rectifier potassium channel 11 K C00026111 3 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00026111 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00026111 2 / 1

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1003 CDH5, 7B4, CD144 cadherin 5, type 2 (vascular endothelium) C00024667
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00024667
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00024667
2048 EPHB2, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5 EPH receptor B2 (EC:2.7.10.1) C00024667
9500 MAGED1, DLXIN-1, NRAGE melanoma antigen family D, 1 C00024667
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00024667
64321 SOX17, VUR3 SRY (sex determining region Y)-box 17 C00024667
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00024667

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc Q14191
#606176 Diabetes mellitus, permanent neonatal; pndm Q09428
Q14654
#610374 Diabetes mellitus, transient neonatal, 2 Q09428
#610582 Diabetes mellitus, transient neonatal, 3 Q14654
#256450 Hyperinsulinemic hypoglycemia, familial, 1; hhf1 Q09428
#601820 Hyperinsulinemic hypoglycemia, familial, 2; hhf2 Q14654
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 Q09428
#240800 Hypoglycemia, leucine-induced; lih Q09428
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (7)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00512 Permanent neonatal diabetes mellitus (PNDM) Q09428 (related)
Q14654 (related)
H00513 Transient neonatal diabetes mellitus (TNDM) Q09428 (related)
Q14654 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) Q09428 (related)
Q14654 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00409 Type II diabetes mellitus Q14654 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009361 Neoplasm Invasiveness C00024667