PCIDB

KNApSAcK Metabolite C00001861

Metabolite

KNApSAcK Entry

id C00001861
Name Glaucine / S-(+)-Glaucine / O,O-Dimethylisoboldine
CAS RN 475-81-0
Standard InChI InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1
Standard InChI (Main Layer) InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 20

Link

ChEMBL

By standard InChI CHEMBL228082
By standard InChI Main Layer CHEMBL36536 CHEMBL228082

KEGG

By LinkDB C09446

CTD

By CAS RN

Species

Summary

Plant class

class name count
eudicotyledons 22
Magnoliophyta 7
rosids 3

Family

family name count
Papaveraceae 14
Berberidaceae 5
Ranunculaceae 3
Lauraceae 3
Annonaceae 3
Euphorbiaceae 2
Rutaceae 1
Magnoliaceae 1

List (32)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Annona reticulata 301862 Annonaceae Magnoliophyta Viridiplantae
Beilschmiedia podagrica 88849 Lauraceae Magnoliophyta Viridiplantae
Berberis densiflora 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis integerrima 1112794 Berberidaceae eudicotyledons Viridiplantae
Berberis numularis 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis oblonga 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis turcomanica 22774 Berberidaceae eudicotyledons Viridiplantae
Ceratocapnos palaestinus 1095358 Papaveraceae eudicotyledons Viridiplantae
Corydalis ambigua 404569 Papaveraceae eudicotyledons Viridiplantae
Corydalis marchalliana 3463 Papaveraceae eudicotyledons Viridiplantae
Croton hemiargyreus 765397 Euphorbiaceae rosids Viridiplantae
Croton lechleri 323063 Euphorbiaceae rosids Viridiplantae
Cryptocarya chinensis 128609 Lauraceae Magnoliophyta Viridiplantae
Dicentra eximia 41767 Papaveraceae eudicotyledons Viridiplantae
Glaucium corniculatum 56852 Papaveraceae eudicotyledons Viridiplantae
Glaucium elegans 56852 Papaveraceae eudicotyledons Viridiplantae
Glaucium flavum 56853 Papaveraceae eudicotyledons Viridiplantae
Glaucium grandiflorum 56852 Papaveraceae eudicotyledons Viridiplantae
Liriodendron tulipifera 3415 Magnoliaceae Magnoliophyta Viridiplantae
Ocotea vellosiana 63801 Lauraceae Magnoliophyta Viridiplantae
Phoenicanthus obliqua 22140 Annonaceae Magnoliophyta Viridiplantae
Platycapnos saxicola 1095362 Papaveraceae eudicotyledons Viridiplantae
Platycapnos spicata 200995 Papaveraceae eudicotyledons Viridiplantae
Platycapnos tenuiloba 1095361 Papaveraceae eudicotyledons Viridiplantae
Rollinia mucosa 301699 Annonaceae Magnoliophyta Viridiplantae
Sarcocapnos baetica 107195 Papaveraceae eudicotyledons Viridiplantae
Sarcocapnos enneaphylla 38924 Papaveraceae eudicotyledons Viridiplantae
Sarcocapnos saetabensis 107196 Papaveraceae eudicotyledons Viridiplantae
Thalictrum flavum 150094 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum ichengense 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum triternatum 46968 Ranunculaceae eudicotyledons Viridiplantae
Zanthoxylum ailanthoides 159071 Rutaceae rosids Viridiplantae

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q96LD8 Sentrin-specific protease 8 Enzyme CHEMBL36536 CHEMBL1738243 (1) CHEMBL1738578 (1)
0 / 0
P42574 Caspase-3 C14 CHEMBL36536 CHEMBL1738414 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL36536 CHEMBL1614166 (1)
1 / 0
Q9BQF6 Sentrin-specific protease 7 Enzyme CHEMBL36536 CHEMBL1738495 (1)
0 / 0
Q9GZR1 Sentrin-specific protease 6 Enzyme CHEMBL36536 CHEMBL1738502 (1)
0 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme CHEMBL228082 CHEMBL812682 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL36536 CHEMBL1614458 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL36536 CHEMBL2114780 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL36536 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL36536 CHEMBL1738588 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL36536 CHEMBL1794483 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL36536 CHEMBL1614421 (1)
4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL36536 CHEMBL1613914 (1)
0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein CHEMBL36536 CHEMBL2354285 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600274 Frontotemporal dementia; ftd P10636
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (6)

KEGG disease name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)