Liriodendron tulipifera

• Index
• Plant Species
• Natural Activity
• Metabolite list (24)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Liriodendron tulipifera
Genus	Liriodendron
Family	Magnoliaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Liriodendron tulipifera
Linked NCBI taxonomy ID	3415
Linked level	species

Family

Family in NCBI taxonomy	Magnoliaceae
ID	3401

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Magnoliophyta
ID	3398

Natural Activity

List (18)

Species	Activity
Liriodendron tulipifera L.	Analgesic
Liriodendron tulipifera L.	Antibacterial
Liriodendron tulipifera L.	Antiinflammatory
Liriodendron tulipifera L.	Antipyretic
Liriodendron tulipifera L.	Antiseptic
Liriodendron tulipifera L.	Aphrodisiac
Liriodendron tulipifera L.	Bitter
Liriodendron tulipifera L.	Candidicide
Liriodendron tulipifera L.	Cardiotonic
Liriodendron tulipifera L.	Depurative
Liriodendron tulipifera L.	Diaphoretic
Liriodendron tulipifera L.	Digitalic
Liriodendron tulipifera L.	Diuretic
Liriodendron tulipifera L.	Fungicide
Liriodendron tulipifera L.	Positive Inotropic
Liriodendron tulipifera L.	Stimulant
Liriodendron tulipifera L.	Tonic
Liriodendron tulipifera L.	Vermifuge

Metabolite list (24)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00028475	Lirioferine					No. 20	No. 4
C00025675	Lauroscholtzine / 2-O-Methylboldine / N-Methyllaurotetanine / (+)-N-Methyllaurotetanine	CHEMBL464099		1 / 1 / 0		No. 20	No. 4
C00001861	Glaucine / S-(+)-Glaucine / O,O-Dimethylisoboldine	CHEMBL36536 CHEMBL228082		14 / 8 / 6		No. 20	No. 4
C00025931	Liriotulipiferine	CHEMBL1996399				No. 20	No. 4
C00001825	Caaverine / (-)-Caaverine					No. 20	No. 4
C00000659	Medioresinol / (+)-Medioresinol	CHEMBL376507 CHEMBL513023		2 / 1 / 1		No. 38	No. 21
C00000642	(+)-Yangambin	CHEMBL510536 CHEMBL454592 CHEMBL1412125		4 / 2 / 0		No. 38	No. 21
C00007190	(+)-Pinoresinol	CHEMBL267963 CHEMBL487611 CHEMBL460862	C103298	7 / 5 / 6		No. 38	No. 21
C00002631	(+)-Lirioresinol B / (+)-Syringaresinol	CHEMBL361362 CHEMBL402653	C042192	1 / 0 / 0		No. 38	No. 21
C00000640	(+)-Eudesmin	CHEMBL519099 CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879	C105875	2 / 0 / 0		No. 38	No. 21
C00001878	Liriodenine / Oxoushinsunine / Spermatheridine	CHEMBL37736	C026980	5 / 3 / 1		No. 74
C00012975	alpha-Liriodenolide / [3aR-(3aalpha,4beta,5abeta,6beta,9aalpha,9bbeta)]-4-(acetyloxy)-3a,4,5,5a,6,7,9a,9b-octahydro-6-hydroxy-5a,9-dimethyl-3-methylenenaphtho[1,2-b]furan-2(3H)-one					No. 157	No. 38
C00012978	gamma-Liriodenolide / [3aR-(3aalpha,4beta,5abeta,6beta,9bbeta)]-4-(acetyloxy)-3a,4,5,5a,6,7,8,9b-Octahydro-6-hydroxy-5a,9-dimethyl-3-methylenenaphtho[1,2-b]furan-2(3H)-one					No. 157	No. 38
C00012982	beta-Liriodenolide / [3aR-(3aalpha,4beta,5abeta,6beta,9aalpha,9bbeta)]-4-(Acetyloxy)decahydro-6-hydroxy-5a-methyl-3,9-bis(methylene)-naphtho[1,2-b]furan-2(3H)-one					No. 157	No. 38
C00020472	Michefuscalide / beta-Cyclolipiferolide		C059287			No. 157	No. 38
C00003378	Tulipinolide	CHEMBL520114				No. 249	No. 38
C00012329	Tulirinol					No. 249	No. 38
C00003379	epi-Tulipinolide	CHEMBL520114				No. 249	No. 38
C00001164	Myoinositol / myo-Inositol	CHEMBL278373 CHEMBL468154 CHEMBL1222251 CHEMBL1231671 CHEMBL1950780		8 / 17 / 18		No. 795
C00003347	1-Peroxyferolide	CHEMBL518136				No. 843	No. 38
C00003319	Lipiferolide					No. 843	No. 38
C00002498	Scoparone / 6,7-Dimethoxycoumarin / Aesculetin dimethyl ether	CHEMBL325864	C018145	4 / 2 / 2	6 / 0	No. 864	No. 25
C00003380	epi-Tulipinolide diepoxide					No. 1056	No. 38
C00012037	Elemanolide / Epitulipdienolide					No. 1132

Human Protein / Gene in interactions

41 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	C00000642 C00001164 C00001861	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000642 C00001861 C00007190	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001164 C00001861	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000640 C00000642	0 / 0
Q14761	Protein tyrosine phosphatase receptor type C-associated protein	Enzyme	C00001861 C00001878	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000640	0 / 0
Q96LD8	Sentrin-specific protease 8	Enzyme	C00001861	0 / 0
P42574	Caspase-3	C14	C00001861	0 / 0
P05091	Aldehyde dehydrogenase, mitochondrial	Oxidoreductase	C00002498	1 / 1
P16278	Beta-galactosidase	Enzyme	C00001164	4 / 6
P30926	Neuronal acetylcholine receptor subunit beta-4	CHRN beta	C00001878	0 / 0
P32297	Neuronal acetylcholine receptor subunit alpha-3	CHRN alpha	C00001878	1 / 0
P17787	Neuronal acetylcholine receptor subunit beta-2	CHRN beta	C00001878	1 / 1
P43681	Neuronal acetylcholine receptor subunit alpha-4	CHRN alpha	C00001878	1 / 1
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00001861	1 / 0
Q9BQF6	Sentrin-specific protease 7	Enzyme	C00001861	0 / 0
Q9GZR1	Sentrin-specific protease 6	Enzyme	C00001861	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00002631	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000659	1 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001861	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001164	11 / 10
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000642	2 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00007190	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00007190	5 / 3
P06280	Alpha-galactosidase A	Enzyme	C00001164	1 / 1
P56817	Beta-secretase 1	A1A	C00002498	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001861	3 / 3
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00007190	0 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000659	0 / 1
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00007190	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001861	4 / 3
O43451	Maltase-glucoamylase, intestinal	Hydrolase	C00001164	0 / 0
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00025675	1 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00007190	0 / 0
P10323	Acrosin	S1A	C00001164	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001861	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00002498	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002498	1 / 1
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00007190	0 / 0
P43351	DNA repair protein RAD52 homolog	Unclassified protein	C00001861	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00001164	1 / 1

6 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002498
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002498
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002498
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002498
5966	REL, C-Rel	v-rel avian reticuloendotheliosis viral oncogene homolog	C00002498
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002498

Related Diseases

Diseases related to proteins in ChEMBL interactions