Species

KNApSAcK Entry

Organism name Ocotea vellosiana
Genus Ocotea
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ocotea
Linked NCBI taxonomy ID 63801
Linked level genus

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001861 External link 512 Glaucine
/ S-(+)-Glaucine
/ O,O-Dimethylisoboldine
CHEMBL36536
CHEMBL228082
14 / 8 / 6 No. 20 No. 4
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00027447 External link 512 Ocotein
/ Ocoteine
/ Thalicmin
/ Thalicmine
CHEMBL443099
No. 20 No. 4
C00027228 External link 512 Nordicentrine
/ (+)-Nordicentrine
CHEMBL518744
C084697
No. 20 No. 4
C00026016 External link 512 Predicentrine
/ (+)-Predicentrine
CHEMBL404136
No. 20 No. 4
C00025827 External link 512 Corydine
/ Glaucentrin
/ (+)-Corydine
/ Glaucentrine
CHEMBL489524
CHEMBL2002847
C067341
1 / 0 / 0 No. 20 No. 4
C00025658 External link 512
/ Eximine
/ Dicentrine
/ d-Dicentrine
/ (+)-Dicentrine
/ O,N-Dimethyllitseferine
CHEMBL464748
CHEMBL478754
C067342
15 / 20 / 16 No. 20 No. 4
C00005864 External link 512 Kaempferol 3-(4''-p-coumarylrhamnoside)
No. 30 No. 15
C00005869 External link 512 Kaempferol 3-(3'',4''-di-p-coumarylrhamnoside)
No. 231
C00005868 External link 512 Kaempferol 3-(2'',4''-di-(E)-p-coumarylrhamnoside)
CHEMBL1642586
CHEMBL1797052
1 / 1 / 1 No. 231
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00027558 External link 512 Leucoxylonine
No. 3042

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00001861 C00001872 C00025658 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 C00025658 C00025827 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001861 C00001872 C00025658 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001861 C00025658 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001861 C00025658 4 / 3
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 C00025658 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001861 C00001872 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001861 C00025658 1 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001861 C00025658 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001861 C00001872 3 / 3
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001861 0 / 0
Q9GZR1 Sentrin-specific protease 6 Enzyme C00001861 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025658 0 / 0
Q9BQF6 Sentrin-specific protease 7 Enzyme C00001861 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025658 1 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001872 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001872 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001861 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001910 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001872 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001872 0 / 1
P98170 E3 ubiquitin-protein ligase XIAP Other cytosolic protein C00005868 1 / 1
P42574 Caspase-3 C14 C00001861 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025658 0 / 0
Q96LD8 Sentrin-specific protease 8 Enzyme C00001861 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025658 0 / 0
P02545 Prelamin-A/C Unclassified protein C00025658 11 / 10
P06746 DNA polymerase beta Enzyme C00025658 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001872 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001872 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00025658 2 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001872 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#300635 Lymphoproliferative syndrome, x-linked, 2; xlp2 P98170
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (26)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00107 Other well-defined immunodeficiency syndromes P98170 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)