PCIDB

KNApSAcK Metabolite C00025658

Metabolite

KNApSAcK Entry

id C00025658
Name / Eximine / Dicentrine / d-Dicentrine / (+)-Dicentrine / O,N-Dimethyllitseferine
CAS RN 517-66-8
Standard InChI InChI=1S/C20H21NO4/c1-21-5-4-11-7-17-20(25-10-24-17)19-13-9-16(23-3)15(22-2)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m0/s1
Standard InChI (Main Layer) InChI=1S/C20H21NO4/c1-21-5-4-11-7-17-20(25-10-24-17)19-13-9-16(23-3)15(22-2)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 20

Link

ChEMBL

By standard InChI CHEMBL464748
By standard InChI Main Layer CHEMBL464748 CHEMBL478754

KEGG

By LinkDB C17426

CTD

By CAS RN C067342

Human Protein / Gene in interaction

15 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme CHEMBL478754 CHEMBL1614079 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL478754 CHEMBL1614544 (1)
11 / 10
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL464748 CHEMBL1067148 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL478754 CHEMBL1614166 (1)
1 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL478754 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL478754 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL478754 CHEMBL1614410 (1)
1 / 3
Q9UNA4 DNA polymerase iota Enzyme CHEMBL478754 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL478754 CHEMBL1737991 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL478754 CHEMBL1614421 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL478754 CHEMBL1738184 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL478754 CHEMBL1613914 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL478754 CHEMBL2354311 (1)
1 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL478754 CHEMBL2114796 (1)
2 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein CHEMBL478754 CHEMBL2354285 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (16)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)