Stephania abyssinica Walp.
Species
KNApSAcK Entry
| Organism name | Stephania abyssinica Walp. |
|---|---|
| Genus | Stephania |
| Family | Menispermaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Stephania |
|---|---|
| Linked NCBI taxonomy ID | 147243 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Menispermaceae |
|---|---|
| ID | 3455 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (17)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00026044
|
Stephalagine
|
No. 20 | No. 4 |
|
||||
|
C00025827
|
Corydine
/ Glaucentrin / (+)-Corydine / Glaucentrine |
CHEMBL489524
CHEMBL2002847 |
C067341
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00025675
|
Lauroscholtzine
/ 2-O-Methylboldine / N-Methyllaurotetanine / (+)-N-Methyllaurotetanine |
CHEMBL464099
|
1 / 1 / 0 | No. 20 | No. 4 |
|
||
|
C00025658
|
/ Eximine / Dicentrine / d-Dicentrine / (+)-Dicentrine / O,N-Dimethyllitseferine |
CHEMBL464748
CHEMBL478754 |
C067342
|
15 / 20 / 16 | No. 20 | No. 4 |
|
|
|
C00025630
|
Stephanine
/ l-Stephanine / (-)-Stephanine / (R)-(-)-Stephanine |
CHEMBL601020
|
C054160
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00025235
|
Crebanin
/ (-)-Crebanine |
CHEMBL604339
CHEMBL1989287 |
C061009
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00025625
|
Roemerine
/ (-)-Remerine / (-)-Aporheine / (-)-Roemerine |
CHEMBL36654
CHEMBL483825 |
C030169
|
23 / 10 / 13 | No. 20 | No. 4 |
|
|
|
C00025319
|
Oxoxylopin
/ Oxoxylopine / Lanuginosine |
CHEMBL389400
|
1 / 4 / 2 | No. 74 |
|
|||
|
C00025849
|
Dicentrinone
/ Oxodicentrine |
CHEMBL463284
|
1 / 0 / 0 | No. 74 |
|
|||
|
C00025100
|
6-Dihydroepistephamiersine 6-acetate
|
No. 395 |
|
|||||
|
C00025751
|
4'-O-Methylstephavanine
|
C085403
|
No. 530 |
|
||||
|
C00025948
|
N,O,O-Trimethylstephavanine
|
No. 530 |
|
|||||
|
C00025130
|
Stephavanine
|
CHEMBL1992988
|
No. 530 |
|
||||
|
C00025115
|
Metaphanine
|
CHEMBL1187163
|
No. 1284 |
|
||||
|
C00025126
|
Stephabyssin
/ Stephabyssine |
No. 1284 |
|
|||||
|
C00025121
|
Prostephabyssin
/ Prostephabyssine |
CHEMBL1096482
|
3 / 0 / 0 | No. 1284 |
|
|||
|
C00025125
|
Stephabolin
/ Stephaboline |
No. 1284 |
|
Human Protein / Gene in interactions
37 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00025235 C00025630 C00025658 C00025827 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00025625 C00025658 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00025625 C00025658 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00025625 C00025658 | 1 / 2 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00025625 C00025658 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00025625 C00025658 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00025625 C00025658 | 1 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00025625 C00025658 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00025625 | 0 / 0 |
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Enzyme | C00025625 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00025849 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00025625 | 2 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00025658 | 11 / 10 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00025625 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00025121 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00025625 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00025319 | 4 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00025625 | 1 / 1 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00025121 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00025121 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00025625 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00025625 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00025625 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00025658 | 4 / 3 |
| O14727 | Apoptotic protease-activating factor 1 | Unclassified protein | C00025625 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00025658 | 0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00025675 | 1 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00025625 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00025658 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00025625 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00025658 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00025625 | 2 / 5 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00025625 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00025625 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00025625 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00025658 | 2 / 1 |
| P43351 | DNA repair protein RAD52 homolog | Unclassified protein | C00025658 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #277700 | Werner syndrome; wrn |
Q14191
|
KEGG DISEASE (29)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|