PCIDB

Stephania discflora Hand.-Mazz.

Species

KNApSAcK Entry

Organism name Stephania discflora Hand.-Mazz.
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00025658 External link 512
/ Eximine
/ Dicentrine
/ d-Dicentrine
/ (+)-Dicentrine
/ O,N-Dimethyllitseferine
CHEMBL464748
CHEMBL478754
C067342
15 / 20 / 16 No. 20 No. 4
C00026150 External link 512 Tetrahydropalmatine
/ dl-Tetrahydropalmatine
/ (+/-)-Tetrahydropalmatine
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025845 External link 512 Dehydroroemerine
/ Dehydroremerine
/ 6a,7-Didehydroaporheine
CHEMBL1171263
C030170
No. 416

Human Protein / Gene in interactions

39 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00025625 C00025658 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025625 C00025658 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025625 C00025658 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025625 C00025658 1 / 2
O75496 Geminin Unclassified protein C00025625 C00025658 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025625 C00025658 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025625 C00025658 1 / 0
P03372 Estrogen receptor NR3A1 C00026150 1 / 1
P14416 D(2) dopamine receptor Dopamine receptor C00026150 2 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00025625 0 / 0
P02545 Prelamin-A/C Unclassified protein C00025658 11 / 10
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025625 2 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025625 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00026150 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025625 1 / 1
P13726 Tissue factor Membrane receptor C00026150 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00025625 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025625 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025658 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026150 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00026150 0 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025625 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00026150 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025625 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025658 4 / 3
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025658 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00026150 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025625 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025658 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025625 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025658 1 / 0
O00255 Menin Unclassified protein C00025625 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00025625 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025625 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00025625 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00025658 2 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025658 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (29)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)