Species

KNApSAcK Entry

Organism name Glaucium corniculatum
Genus Glaucium
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Glaucium
Linked NCBI taxonomy ID 56852
Linked level genus

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005548 External link 512 Narcissin
/ Isorhamnetin 3-O-rutinoside
CHEMBL84174
CHEMBL258394
CHEMBL1711509
CHEMBL2165403
C031062
7 / 1 / 2 No. 1 No. 15
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00001861 External link 512 Glaucine
/ S-(+)-Glaucine
/ O,O-Dimethylisoboldine
CHEMBL36536
CHEMBL228082
14 / 8 / 6 No. 20 No. 4
C00001824 External link 512 Bulbocapnine
/ d-Bulbocapnine
CHEMBL157912
C083807
0 / 1 No. 20 No. 4
C00027238 External link 512 Thalicmidine
/ Thaliporphine
/ (+)-Thaliporphine
/ (S)-O-Methylisoboldine
CHEMBL1394328
CHEMBL1397308
C080702
20 / 26 / 56 No. 20 No. 4
C00025658 External link 512
/ Eximine
/ Dicentrine
/ d-Dicentrine
/ (+)-Dicentrine
/ O,N-Dimethyllitseferine
CHEMBL464748
CHEMBL478754
C067342
15 / 20 / 16 No. 20 No. 4
C00025827 External link 512 Corydine
/ Glaucentrin
/ (+)-Corydine
/ Glaucentrine
CHEMBL489524
CHEMBL2002847
C067341
1 / 0 / 0 No. 20 No. 4
C00025674 External link 512 N-Methylcorydine
/ (+)-N-Methylcorydine
CHEMBL1617951
No. 286 No. 4
C00027386 External link 512 Isocorydine-N-oxide
/ (+)-Isocorydine N-oxide
No. 286 No. 4
C00027532 External link 512 Corydine N-oxide
No. 286 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4

Human Protein / Gene in interactions

48 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001861 C00001872 C00001906 C00025658 C00027238 0 / 0
O75496 Geminin Unclassified protein C00001861 C00001872 C00005548 C00025658 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001872 C00001906 C00005548 C00027238 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001799 C00001861 C00005548 C00025658 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001872 C00001906 C00027238 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001861 C00025658 C00027238 4 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00001861 C00001872 C00027238 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001861 C00001872 C00027238 3 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 C00025658 C00027238 1 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 C00025658 C00025827 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001872 C00001906 C00027238 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001861 C00005548 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 C00025658 1 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001861 C00025658 1 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001861 C00025658 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001872 0 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001861 0 / 0
Q9BQF6 Sentrin-specific protease 7 Enzyme C00001861 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025658 0 / 0
P54132 Bloom syndrome protein Enzyme C00027238 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00005548 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005548 0 / 0
P06280 Alpha-galactosidase A Enzyme C00027238 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00027238 0 / 0
Q9GZR1 Sentrin-specific protease 6 Enzyme C00001861 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001872 0 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00027238 2 / 2
P42574 Caspase-3 C14 C00001861 0 / 0
P03372 Estrogen receptor NR3A1 C00005548 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00027238 0 / 0
P55210 Caspase-7 C14 C00027238 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00027238 3 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00001906 3 / 2
Q96LD8 Sentrin-specific protease 8 Enzyme C00001861 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025658 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00027238 0 / 0
P02545 Prelamin-A/C Unclassified protein C00025658 11 / 10
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025658 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00027238 0 / 0
P29466 Caspase-1 C14 C00027238 0 / 0
P06746 DNA polymerase beta Enzyme C00025658 0 / 0
O00255 Menin Unclassified protein C00027238 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00001872 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001872 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00025658 2 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00027238 7 / 37
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799 C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799 C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (47)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (71)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00125 Fabry disease P06280 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00001824