PCIDB

Lindera megaphylla

Family in NCBI taxonomy	Lauraceae
ID	3433

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class	Magnoliophyta
ID	3398

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	KCF-S cluster	phytochemical cluster
C00028701	N-Methylhernovine / (-)-N-Methylhernovine	CHEMBL1183924			No. 20	No. 4
C00027450	O-Methylbulbocapnine	CHEMBL464955			No. 20	No. 4
C00025658	/ Eximine / Dicentrine / d-Dicentrine / (+)-Dicentrine / O,N-Dimethyllitseferine	CHEMBL464748 CHEMBL478754	C067342	15 / 20 / 16	No. 20	No. 4
C00005851	Tiliroside / Potengriffioside A / Kaempferol 3-O-beta-D-(6''-coumaroyl)-glucopyranoside	CHEMBL266564 CHEMBL499705	C052083	2 / 1 / 2	No. 30	No. 15
C00025849	Dicentrinone / Oxodicentrine	CHEMBL463284		1 / 0 / 0	No. 74
C00001910	Reticuline / (+)-Reticuline	CHEMBL235212 CHEMBL401501 CHEMBL464734	C003298	1 / 0 / 0	No. 345	No. 4
C00027155	Northalifoline				No. 2199

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P06746	DNA polymerase beta	Enzyme	C00025658	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00025658	11 / 10
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00005851	1 / 1
P24941	Cyclin-dependent kinase 2	Cdc2	C00025658	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00025658	1 / 0
P11387	DNA topoisomerase 1	Isomerase	C00025849	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00025658	0 / 0
O75496	Geminin	Unclassified protein	C00025658	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00025658	1 / 2
P35372	Mu-type opioid receptor	Opioid receptor	C00001910	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00005851	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00025658	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00025658	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00025658	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00025658	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00025658	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00025658	1 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00025658	2 / 1
P43351	DNA repair protein RAD52 homolog	Unclassified protein	C00025658	0 / 0

OMIM	preferred title	UniProt
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#114500	Colorectal cancer; crc	Q14191
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#600274	Frontotemporal dementia; ftd	P10636
#137800	Glioma susceptibility 1; glm1	O75874
#605130	Hairy elbows, short stature, facial dysmorphism, and developmental delay	Q03164
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#160900	Myotonic dystrophy 1; dm1	Q9NR56
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#275210	Restrictive dermopathy, lethal	P02545
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636
#277700	Werner syndrome; wrn	Q14191
#278300	Xanthinuria, type i	P47989

KEGG	name	UniProt
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00036	Osteosarcoma	P08684 (marker)
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)
H00192	Xanthinuria	P47989 (related)
H00001	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Q03164 (related) Q03164 (marker)
H00002	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Q03164 (related)
H00296	Defects in RecQ helicases	Q14191 (related)