Cissampelos pareira L.
Species
KNApSAcK Entry
| Organism name | Cissampelos pareira L. |
|---|---|
| Genus | Cissampelos |
| Family | Menispermaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cissampelos pareira |
|---|---|
| Linked NCBI taxonomy ID | 108409 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Menispermaceae |
|---|---|
| ID | 3455 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (79)
| Species | Activity |
|---|---|
| Cissampelos pareira L. | Alexeteric |
| Cissampelos pareira L. | Alexiteric |
| Cissampelos pareira L. | Analgesic |
| Cissampelos pareira L. | Analgesic |
| Cissampelos pareira L. | Antiabortive |
| Cissampelos pareira L. | Antiabortive |
| Cissampelos pareira L. | Antiarthritic |
| Cissampelos pareira L. | Anticancer |
| Cissampelos pareira L. | Anticonvulsant |
| Cissampelos pareira L. | Antidiarrheal |
| Cissampelos pareira L. | Antidote |
| Cissampelos pareira L. | Antiecbolic |
| Cissampelos pareira L. | Antiedemic |
| Cissampelos pareira L. | Antifertility |
| Cissampelos pareira L. | Antihistaminic |
| Cissampelos pareira L. | Antiinflammatory |
| Cissampelos pareira L. | Antiinflammatory |
| Cissampelos pareira L. | Antileukemic |
| Cissampelos pareira L. | Antilithic |
| Cissampelos pareira L. | Antimalarial |
| Cissampelos pareira L. | Antioxidant |
| Cissampelos pareira L. | Antiplasmodial |
| Cissampelos pareira L. | Antipyretic |
| Cissampelos pareira L. | Antiradicular |
| Cissampelos pareira L. | Antiseptic |
| Cissampelos pareira L. | Antispasmodic |
| Cissampelos pareira L. | Antitrypanosomic |
| Cissampelos pareira L. | Antiulcer |
| Cissampelos pareira L. | Aphrodisiac |
| Cissampelos pareira L. | Astringent |
| Cissampelos pareira L. | Astringent |
| Cissampelos pareira L. | Bactericide |
| Cissampelos pareira L. | Bitter |
| Cissampelos pareira L. | Bitter |
| Cissampelos pareira L. | Bradycardiac |
| Cissampelos pareira L. | Cardiotonic |
| Cissampelos pareira L. | CNS-Depressant |
| Cissampelos pareira L. | Contraceptive |
| Cissampelos pareira L. | Curare |
| Cissampelos pareira L. | Curare |
| Cissampelos pareira L. | Cytotoxic |
| Cissampelos pareira L. | Depurative |
| Cissampelos pareira L. | Depurative |
| Cissampelos pareira L. | Diaphoretic |
| Cissampelos pareira L. | Diaphoretic |
| Cissampelos pareira L. | Diuretic |
| Cissampelos pareira L. | Diuretic |
| Cissampelos pareira L. | Emmenagogue |
| Cissampelos pareira L. | Emmenagogue |
| Cissampelos pareira L. | Expectorant |
| Cissampelos pareira L. | Expectorant |
| Cissampelos pareira L. | Febrifuge |
| Cissampelos pareira L. | Gram(+)-icide |
| Cissampelos pareira L. | Hemostat |
| Cissampelos pareira L. | Hemostat |
| Cissampelos pareira L. | Hepatoprotective |
| Cissampelos pareira L. | Hypertensive |
| Cissampelos pareira L. | Hypotensive |
| Cissampelos pareira L. | Litholytic |
| Cissampelos pareira L. | Litholytic |
| Cissampelos pareira L. | Mucolytic |
| Cissampelos pareira L. | Myorelaxant |
| Cissampelos pareira L. | Myorelaxant |
| Cissampelos pareira L. | Piscicide |
| Cissampelos pareira L. | Piscicide |
| Cissampelos pareira L. | Poison |
| Cissampelos pareira L. | Poison |
| Cissampelos pareira L. | Purgative |
| Cissampelos pareira L. | Respirodepressant |
| Cissampelos pareira L. | Sedative |
| Cissampelos pareira L. | Stimulant |
| Cissampelos pareira L. | Stomachic |
| Cissampelos pareira L. | Stomachic |
| Cissampelos pareira L. | Styptic |
| Cissampelos pareira L. | Tonic |
| Cissampelos pareira L. | Tonic |
| Cissampelos pareira L. | Uterorelaxant |
| Cissampelos pareira L. | Vulnerary |
| Cissampelos pareira L. | Vulnerary |
Metabolite list (21)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001870
|
Isobebeerin
/ Isobebeerine / Isochondodendrine |
CHEMBL509310
CHEMBL1169628 |
No. 10 | No. 4 |
|
|||
|
C00025901
|
Insularine
/ O-Methylinsulanoline |
No. 10 | No. 4 |
|
||||
|
C00025602
|
l-Curine
/ (-)-Curine / l-Bebeerine / Aristolochine / (-)-Bebeerine / Aristolochine(C36 alkaloid) |
CHEMBL1169627
|
13 / 6 / 5 | No. 10 | No. 4 |
|
||
|
C00025604
|
Cycleanine
/ (-)-Cycleanine |
CHEMBL1711244
CHEMBL1983719 |
C037098
|
7 / 1 / 1 | No. 10 | No. 4 |
|
|
|
C00025886
|
Hayatinine
/ (+)-Hayatinine |
CHEMBL454476
|
No. 10 | No. 4 |
|
|||
|
C00025885
|
Hayatine
/ (+/-)-Curine / (+/-)-Bebeerine |
CHEMBL1169627
|
13 / 6 / 5 | No. 10 | No. 4 |
|
||
|
C00025658
|
/ Eximine / Dicentrine / d-Dicentrine / (+)-Dicentrine / O,N-Dimethyllitseferine |
CHEMBL464748
CHEMBL478754 |
C067342
|
15 / 20 / 16 | No. 20 | No. 4 |
|
|
|
C00025976
|
Nuciferine
|
CHEMBL464529
|
C008692
|
0 / 1 | No. 20 | No. 4 |
|
|
|
C00025655
|
Corytuberine
/ (+)-Corytuberine |
CHEMBL227965
|
C013896
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00025295
|
beta-Cyclanoline
/ (-)-b-Cyclanoline |
CHEMBL2008127
|
No. 234 |
|
||||
|
C00025798
|
Cissamine
|
CHEMBL2008127
|
C060801
|
No. 234 |
|
|||
|
C00026120
|
Cyclanoline
/ (-)-Cissamine / alpha-Cyclanoline |
CHEMBL2008127
|
C060801
|
No. 234 |
|
|||
|
C00025842
|
Dehydrodicentrine
|
CHEMBL456942
|
No. 416 |
|
||||
|
C00025835
|
Daijisong
/ Hayatine dimethiodide |
CHEMBL329050
CHEMBL1566620 |
6 / 5 / 5 | No. 1154 |
|
|||
|
C00025879
|
Grandirubrine
|
CHEMBL155235
|
No. 1562 |
|
||||
|
C00025908
|
Isoimerubrine
|
No. 1562 |
|
|||||
|
C00026006
|
Pareitropone
|
No. 1562 |
|
|||||
|
C00026004
|
Pareirubrine
/ Pareirubrine A |
C083802
|
No. 1562 |
|
||||
|
C00026005
|
Pareirubrine B
|
C083803
|
No. 1562 |
|
||||
|
C00025961
|
Norimelutein
/ Norimeluteine |
No. 1565 |
|
|||||
|
C00025963
|
Norrufescine
|
CHEMBL155844
|
No. 1565 |
|
Human Protein / Gene in interactions
33 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00025602 C00025604 C00025658 C00025885 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00025602 C00025604 C00025658 C00025885 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00025602 C00025604 C00025885 | 1 / 1 |
| P43351 | DNA repair protein RAD52 homolog | Unclassified protein | C00025602 C00025658 C00025885 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00025602 C00025658 C00025885 | 4 / 3 |
| P47898 | 5-hydroxytryptamine receptor 5A | Serotonin receptor | C00025602 C00025885 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00025602 C00025885 | 0 / 0 |
| O43603 | Galanin receptor type 2 | Galanin receptor | C00025602 C00025885 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00025655 C00025658 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00025602 C00025885 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00025604 C00025658 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00025602 C00025885 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00025602 C00025885 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00025602 C00025885 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00025602 C00025885 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00025658 | 1 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00025604 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00025835 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00025658 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00025835 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00025835 | 0 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00025658 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00025835 | 0 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00025835 | 3 / 2 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00025658 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00025658 | 11 / 10 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00025604 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00025658 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00025658 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00025658 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00025604 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00025658 | 2 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00025835 | 1 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (27)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277700 | Werner syndrome; wrn |
Q14191
|
KEGG DISEASE (23)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|