Species

KNApSAcK Entry

Organism name Illigera luzonensis
Genus Illigera
Family Hernandiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Illigera luzonensis
Linked NCBI taxonomy ID 74946
Linked level species

Family

Family in NCBI taxonomy Hernandiaceae
ID 22009

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001790 External link 512 Actinodaphnine
/ (+)-Actinodaphnine
/ 1,2-Methylenedioxy-9-hydroxy-10-methoxynoraporphine
CHEMBL518088
CHEMBL1588263
C060992
30 / 32 / 24 No. 20 No. 4
C00001824 External link 512 Bulbocapnine
/ d-Bulbocapnine
CHEMBL157912
C083807
0 / 1 No. 20 No. 4
C00001834 External link 512 Cassythicine
/ (+)-Cassythicine
/ N-Methylactinodaphnine
/ (+)-N-Methylactinodaphnine
CHEMBL464528
No. 20 No. 4
C00027450 External link 512 O-Methylbulbocapnine
CHEMBL464955
No. 20 No. 4
C00027407 External link 512 Launobine
/ (+)-Launobine
CHEMBL516862
No. 20 No. 4
C00025658 External link 512
/ Eximine
/ Dicentrine
/ d-Dicentrine
/ (+)-Dicentrine
/ O,N-Dimethyllitseferine
CHEMBL464748
CHEMBL478754
C067342
15 / 20 / 16 No. 20 No. 4
C00001878 External link 512 Liriodenine
/ Oxoushinsunine
/ Spermatheridine
CHEMBL37736
C026980
5 / 3 / 1 No. 74
C00025849 External link 512 Dicentrinone
/ Oxodicentrine
CHEMBL463284
1 / 0 / 0 No. 74
C00027376 External link 512 Ovigerine
/ Hernovine
/ (+)-Ovigerine
No. 1625

Human Protein / Gene in interactions

39 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00001790 C00025658 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001790 C00025658 2 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001790 C00025658 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001790 C00025658 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001790 C00025658 4 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00001790 C00025658 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001790 C00025658 11 / 10
Q9UNA4 DNA polymerase iota Enzyme C00001790 C00025658 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001790 C00025658 1 / 2
O75496 Geminin Unclassified protein C00001790 C00025658 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001790 C00025658 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001790 C00025658 1 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001790 2 / 0
P11387 DNA topoisomerase 1 Isomerase C00025849 0 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001878 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001790 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001790 2 / 2
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001878 1 / 1
P42858 Huntingtin Unclassified protein C00001790 1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001878 1 / 1
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001878 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001790 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001790 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001790 0 / 0
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001878 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00001790 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001790 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001790 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025658 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001790 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001790 0 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00001790 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025658 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001790 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001790 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001790 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001790 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001790 4 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025658 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (25)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00001824