PCIDB

Dicentra oregana Eastwood.

Species

KNApSAcK Entry

Organism name Dicentra oregana Eastwood.
Genus Dicentra
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dicentra
Linked NCBI taxonomy ID 22680
Linked level genus

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025658 External link 512
/ Eximine
/ Dicentrine
/ d-Dicentrine
/ (+)-Dicentrine
/ O,N-Dimethyllitseferine
CHEMBL464748
CHEMBL478754
C067342
15 / 20 / 16 No. 20 No. 4
C00026117 External link 512 Corypalmine
/ (-)-Corypalmine
CHEMBL2334885
CHEMBL2334886
4 / 3 / 0 No. 37 No. 4
C00001842 External link 512 Cularine
/ (+)-Cularine
C064577
No. 361
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00001799 C00025658 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 C00025658 1 / 2
P21728 D(1A) dopamine receptor Dopamine receptor C00026117 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025658 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025658 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00026117 2 / 0
P39748 Flap endonuclease 1 Enzyme C00025658 0 / 0
O75496 Geminin Unclassified protein C00025658 0 / 0
P06746 DNA polymerase beta Enzyme C00025658 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026117 0 / 0
P02545 Prelamin-A/C Unclassified protein C00025658 11 / 10
O75164 Lysine-specific demethylase 4A Enzyme C00025658 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025658 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025658 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00026117 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025658 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025658 1 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00025658 2 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025658 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (16)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)