Species

KNApSAcK Entry

Organism name Ceratocapnos palaestinus
Genus Ceratocapnos
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ceratocapnos
Linked NCBI taxonomy ID 1095358
Linked level genus

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (25)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00027238 External link 512 Thalicmidine
/ Thaliporphine
/ (+)-Thaliporphine
/ (S)-O-Methylisoboldine
CHEMBL1394328
CHEMBL1397308
C080702
20 / 26 / 56 No. 20 No. 4
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00025676 External link 512 Norglaucin
/ Norglaucine
/ (+)-Norglaucine
/ O,O-Dimethyllaurelliptine
No. 20 No. 4
C00001861 External link 512 Glaucine
/ S-(+)-Glaucine
/ O,O-Dimethylisoboldine
CHEMBL36536
CHEMBL228082
14 / 8 / 6 No. 20 No. 4
C00024773 External link 512 Oxocularine
CHEMBL510574
No. 74
C00024774 External link 512 Oxosarcocapnidine
No. 74
C00024772 External link 512 Oxocompostelline
No. 74
C00024623 External link 512 Chelidonin
/ Stylophorine
/ (+)-Chelidonine
CHEMBL436279
CHEMBL496867
CHEMBL1394506
CHEMBL2009780
C062047
8 / 19 / 21 1 / 2 No. 233 No. 4
C00025924 External link 512 Juziphine
/ Yuziphine
/ (+)-Juziphine
CHEMBL462956
No. 253 No. 4
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00024761 External link 512 Norcularicine
/ (+)-Norcularicine
No. 361
C00024764 External link 512 Sarcocapnidine
/ (+)-Sarcocapnidine
CHEMBL510777
No. 361
C00024765 External link 512 Sarcocapnine
/ (+)-Sarcocapnine
No. 361
C00024759 External link 512 Enneaphylline
/ (+)-Enneaphylline
No. 361
C00024758 External link 512 Claviculine
/ (+)-Claviculine
CHEMBL452512
No. 361
C00001842 External link 512 Cularine
/ (+)-Cularine
C064577
No. 361
C00001841 External link 512 Cularimine
/ (+)-Cularimine
No. 361
C00024756 External link 512 Celtine
/ (+)-Celtine
No. 361
C00025629 External link 512 Sinoacutine
/ (-)-Sinoacutine
/ (-)-Salutaridine
CHEMBL402782
CHEMBL404097
3 / 4 / 2 No. 426 No. 4
C00027394 External link 512 Isosalutaridine
No. 426 No. 4
C00028768 External link 512 Fissistigine C
/ O-Methylpallidine
CHEMBL224744
CHEMBL490139
No. 426 No. 4
C00001820 External link 512 Bucuculline
/ Bicucullin
/ (+)-Bicuculline
CHEMBL417990
CHEMBL1316579
CHEMBL1437488
CHEMBL1444722
D001640
30 / 28 / 20 0 / 21 No. 605 No. 4
C00028026 External link 512 Ceratonicine
No. 1978
C00028025 External link 512 Ceratocapnine
No. 1978
C00028024 External link 512 Ceratocapnidine
No. 1978

Human Protein / Gene in interactions

62 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001820 C00001869 C00024623 C00027238 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001861 C00001869 C00024623 C00027238 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001820 C00001869 C00024623 C00027238 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001820 C00001869 C00024623 C00027238 0 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001869 C00024623 C00027238 1 / 2
P10636 Microtubule-associated protein tau Unclassified protein C00001861 C00001869 C00027238 4 / 3
O00255 Menin Unclassified protein C00001869 C00024623 C00027238 2 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001861 C00001869 C00027238 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001861 C00001869 C00027238 3 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00001869 C00027238 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001820 C00024623 3 / 2
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 C00027238 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001820 C00024623 11 / 10
P29466 Caspase-1 C14 C00001869 C00027238 0 / 0
P55210 Caspase-7 C14 C00001869 C00027238 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001910 C00025629 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 C00027238 7 / 37
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 C00027238 2 / 2
O75496 Geminin Unclassified protein C00001820 C00001861 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001820 C00001869 0 / 1
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001820 1 / 1
P06280 Alpha-galactosidase A Enzyme C00027238 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00027238 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001820 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001820 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001820 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001861 0 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001861 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00027238 0 / 0
Q9GZR1 Sentrin-specific protease 6 Enzyme C00001861 0 / 0
Q9BQF6 Sentrin-specific protease 7 Enzyme C00001861 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001861 1 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001861 0 / 0
P54132 Bloom syndrome protein Enzyme C00027238 1 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 C00025629 0 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001820 1 / 1
P42574 Caspase-3 C14 C00001861 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001820 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00027238 3 / 1
Q96LD8 Sentrin-specific protease 8 Enzyme C00001861 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001869 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001869 1 / 4
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001820 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001820 1 / 0
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001820 0 / 0
P00734 Prothrombin S1A C00025629 4 / 2
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001820 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001820 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001820 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001820 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001820 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001820 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001820 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001820 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001820 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001820 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001820 1 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00001820 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00001820 2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00001820 3 / 2
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001861 0 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00024623

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P47869
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#133239 Esophageal cancer P04637
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (78)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
P35498 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00125 Fabry disease P06280 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

21 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00024623
C00001820
D009069 Movement Disorders C00024623
C00001820
D006973 Hypertension C00001820
D000648 Amnesia, Retrograde C00001820
D001008 Anxiety Disorders C00001820
D001919 Bradycardia C00001820
D004487 Edema C00001820
D004827 Epilepsy C00001820
D005119 Extravasation of Diagnostic and Therapeutic Materials C00001820
D006930 Hyperalgesia C00001820
D000647 Amnesia C00001820
D007022 Hypotension C00001820
D009207 Myoclonus C00001820
D009436 Neural Tube Defects C00001820
D020078 Neurogenic Inflammation C00001820
D020336 Paraparesis, Spastic C00001820
D010409 Penile Diseases C00001820
D049188 Prenatal Injuries C00001820
D012640 Seizures C00001820
D013035 Spasm C00001820
D013226 Status Epilepticus C00001820