Croton lechleri
Species
KNApSAcK Entry
| Organism name | Croton lechleri |
|---|---|
| Genus | Croton |
| Family | Euphorbiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Croton lechleri |
|---|---|
| Linked NCBI taxonomy ID | 323063 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Euphorbiaceae |
|---|---|
| ID | 3977 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (41)
| Species | Activity |
|---|---|
| Croton lechleri Mull. Arg. | Analgesic |
| Croton lechleri Mull. Arg. | Anticomplement |
| Croton lechleri Mull. Arg. | Antiedemic |
| Croton lechleri Mull. Arg. | Antiherpetic |
| Croton lechleri Mull. Arg. | Antiherpetic |
| Croton lechleri Mull. Arg. | Antiinflammatory |
| Croton lechleri Mull. Arg. | Antiinflammatory |
| Croton lechleri Mull. Arg. | Antileukemic |
| Croton lechleri Mull. Arg. | Antimutagenic |
| Croton lechleri Mull. Arg. | Antioxidant |
| Croton lechleri Mull. Arg. | Antioxidant |
| Croton lechleri Mull. Arg. | Antiphagocytotic |
| Croton lechleri Mull. Arg. | Antiradicular |
| Croton lechleri Mull. Arg. | Antiradicular |
| Croton lechleri Mull. Arg. | Antirheumatic |
| Croton lechleri Mull. Arg. | Antiseptic |
| Croton lechleri Mull. Arg. | Antiseptic |
| Croton lechleri Mull. Arg. | Antitumor |
| Croton lechleri Mull. Arg. | Antitumor |
| Croton lechleri Mull. Arg. | Antiulcer |
| Croton lechleri Mull. Arg. | Antiviral |
| Croton lechleri Mull. Arg. | Antiviral |
| Croton lechleri Mull. Arg. | Astringent |
| Croton lechleri Mull. Arg. | Bactericide |
| Croton lechleri Mull. Arg. | Candidicide |
| Croton lechleri Mull. Arg. | Cicatrizant |
| Croton lechleri Mull. Arg. | Cicatrizant |
| Croton lechleri Mull. Arg. | Contraceptive |
| Croton lechleri Mull. Arg. | Cytotoxic |
| Croton lechleri Mull. Arg. | Cytotoxic |
| Croton lechleri Mull. Arg. | Fungicide |
| Croton lechleri Mull. Arg. | Hemostat |
| Croton lechleri Mull. Arg. | Hemostat |
| Croton lechleri Mull. Arg. | Immunodepressant |
| Croton lechleri Mull. Arg. | Immunomodulator |
| Croton lechleri Mull. Arg. | Immunostimulant |
| Croton lechleri Mull. Arg. | Neuroprotective |
| Croton lechleri Mull. Arg. | Phagocytotic |
| Croton lechleri Mull. Arg. | Prooxidant |
| Croton lechleri Mull. Arg. | Vulnerary |
| Croton lechleri Mull. Arg. | Vulnerary |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00009082
|
Catechin-(4alpha->8)-epigallocatechin
|
No. 16 | No. 19 |
|
||||
|
C00009112
|
Gallocatechin-(4alpha->8)-epicatechin
|
No. 16 | No. 19 |
|
||||
|
C00001861
|
Glaucine
/ S-(+)-Glaucine / O,O-Dimethylisoboldine |
CHEMBL36536
CHEMBL228082 |
14 / 8 / 6 | No. 20 | No. 4 |
|
||
|
C00027238
|
Thalicmidine
/ Thaliporphine / (+)-Thaliporphine / (S)-O-Methylisoboldine |
CHEMBL1394328
CHEMBL1397308 |
C080702
|
20 / 26 / 56 | No. 20 | No. 4 |
|
|
|
C00009100
|
Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-gallocatechin
|
No. 29 | No. 19 |
|
||||
|
C00008817
|
Gallocatechin
/ (+)-Gallocatechin / (+)-Gallocatechol / (2R,3S)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol |
CHEMBL47386
CHEMBL125743 CHEMBL130415 CHEMBL264167 CHEMBL404845 |
26 / 17 / 29 | No. 52 | No. 14 |
|
||
|
C00008818
|
Epigallocatechin
/ (-)-Epigallocatechin |
CHEMBL47386
CHEMBL125743 CHEMBL130415 CHEMBL264167 CHEMBL404845 |
26 / 17 / 29 | No. 52 | No. 14 |
|
||
|
C00009122
|
[Epigallocatechin-(4->8)]3-epigallocatechin
|
No. 113 | No. 19 |
|
Human Protein / Gene in interactions
48 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001861 C00008817 C00008818 C00027238 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001861 C00008817 C00008818 C00027238 | 3 / 3 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001861 C00008817 C00008818 C00027238 | 4 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001861 C00008817 C00008818 C00027238 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00008817 C00008818 C00027238 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00008817 C00008818 C00027238 | 2 / 2 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00008817 C00008818 C00027238 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00008817 C00008818 C00027238 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00008817 C00008818 | 0 / 3 |
| P02768 | Serum albumin | Secreted protein | C00008817 C00008818 | 0 / 0 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00008817 C00008818 | 0 / 7 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00008817 C00008818 | 0 / 0 |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00008817 C00008818 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00008817 C00008818 | 1 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00008817 C00008818 | 2 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00008817 C00008818 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00008817 C00008818 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00008817 C00008818 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00008817 C00008818 | 1 / 1 |
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00008817 C00008818 | 1 / 1 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00008817 C00008818 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00008817 C00008818 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00008817 C00008818 | 0 / 1 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00008817 C00008818 | 2 / 3 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00008817 C00008818 | 1 / 4 |
| P56817 | Beta-secretase 1 | A1A | C00008817 C00008818 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00027238 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00027238 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001861 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001861 | 0 / 0 |
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Enzyme | C00001861 | 0 / 0 |
| Q9GZR1 | Sentrin-specific protease 6 | Enzyme | C00001861 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00027238 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00027238 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00027238 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001861 | 0 / 0 |
| Q9BQF6 | Sentrin-specific protease 7 | Enzyme | C00001861 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001861 | 1 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00027238 | 1 / 2 |
| P42574 | Caspase-3 | C14 | C00001861 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00027238 | 3 / 1 |
| Q96LD8 | Sentrin-specific protease 8 | Enzyme | C00001861 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00027238 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00027238 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00027238 | 1 / 2 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00027238 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00027238 | 7 / 37 |
| P43351 | DNA repair protein RAD52 homolog | Unclassified protein | C00001861 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (35)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (66)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P10415 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
P10415 (related) |
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
P08581 (related) P10415 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
P10415 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
P10415 (related) |
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
P08581 (related) |
| H00125 | Fabry disease |
P06280
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|