Metabolite

KNApSAcK Entry

id C00008818
Name Epigallocatechin / (-)-Epigallocatechin
CAS RN 970-74-1
Standard InChI InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1
Standard InChI (Main Layer) InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 52

Link

ChEMBL

By standard InChI CHEMBL47386
By standard InChI Main Layer CHEMBL47386 CHEMBL125743 CHEMBL130415 CHEMBL264167 CHEMBL404845

KEGG

By LinkDB C12136

CTD

By CAS RN

Human Protein / Gene in interaction

26 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL125743 CHEMBL1008510 (1)
0 / 3
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme CHEMBL47386 CHEMBL264167 CHEMBL921930 (2)
0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL47386 CHEMBL1023248 (1)
1 / 1
P02768 Serum albumin Secreted protein CHEMBL47386 CHEMBL1177441 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL404845 CHEMBL1794311 (1)
2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL125743 CHEMBL1008496 (1)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL47386 CHEMBL926465 (1) CHEMBL926470 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL404845 CHEMBL1614458 (1)
0 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL47386 CHEMBL926467 (1) CHEMBL926472 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL404845 CHEMBL1794467 (1)
0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL47386 CHEMBL1056839 (1)
2 / 3
P56817 Beta-secretase 1 A1A CHEMBL125743 CHEMBL130415 CHEMBL653507 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL404845 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL404845 CHEMBL1614038 (1)
2 / 2
P00374 Dihydrofolate reductase Oxidoreductase CHEMBL47386 CHEMBL930269 (1)
1 / 1
P35372 Mu-type opioid receptor Opioid receptor CHEMBL47386 CHEMBL926466 (1) CHEMBL926471 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL404845 CHEMBL1614240 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL404845 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL404845 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein CHEMBL47386 CHEMBL937576 (1)
0 / 7
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL404845 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL404845 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL404845 CHEMBL1613829 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL404845 CHEMBL1614364 (1) CHEMBL1738394 (1)
1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL404845 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL404845 CHEMBL1613933 (1)
1 / 6

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#119900 Digital clubbing, isolated congenital P15428
#600274 Frontotemporal dementia; ftd P10636
#114550 Hepatocellular carcinoma P08581
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989

KEGG DISEASE (29)

KEGG disease name UniProt
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
H00013 Small cell lung cancer P10415 (related)
H00028 Choriocarcinoma P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)