Species

KNApSAcK Entry

Organism name Syzygium spp.
Genus Syzygium
Family Myrtaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Syzygium
Linked NCBI taxonomy ID 178174
Linked level genus

Family

Family in NCBI taxonomy Myrtaceae
ID 3931

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00008818 External link 512 Epigallocatechin
/ (-)-Epigallocatechin
CHEMBL47386
CHEMBL125743
CHEMBL130415
CHEMBL264167
CHEMBL404845
26 / 17 / 29 No. 52 No. 14

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00008818 0 / 3
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00008818 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00008818 1 / 1
P02768 Serum albumin Secreted protein C00008818 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00008818 2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00008818 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00008818 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00008818 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00008818 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00008818 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00008818 2 / 3
P56817 Beta-secretase 1 A1A C00008818 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00008818 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00008818 2 / 2
P00374 Dihydrofolate reductase Oxidoreductase C00008818 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00008818 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00008818 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00008818 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00008818 4 / 3
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00008818 0 / 7
Q9UBT6 DNA polymerase kappa Enzyme C00008818 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00008818 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00008818 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00008818 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00008818 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00008818 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#119900 Digital clubbing, isolated congenital P15428
#600274 Frontotemporal dementia; ftd P10636
#114550 Hepatocellular carcinoma P08581
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989

KEGG DISEASE (29)

KEGG name UniProt
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
H00013 Small cell lung cancer P10415 (related)
H00028 Choriocarcinoma P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)