Species

KNApSAcK Entry

Organism name Rhodiola sachalinensis
Genus Rhodiola
Family Crassulaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rhodiola sachalinensis
Linked NCBI taxonomy ID 265354
Linked level species

Family

Family in NCBI taxonomy Crassulaceae
ID 3781

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (45)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005347 External link 512 Rhodiosin
/ Herbacetin 7-glucosyl-(1->3)-rhamnoside
CHEMBL596218
No. 1 No. 15
C00005163 External link 512 Leucoside
/ Kaempferol 3-sambubioside
/ 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-[(2-O-beta-D-xylopyranosyl-beta-D-glucopyranosyl)oxy]-4H-1-benzopyran-4-one
CHEMBL446574
CHEMBL1096690
No. 1 No. 15
C00005338 External link 512 Rhodionin
/ Herbacetin 7-rhamnoside
/ Herbacetin 7-O-alpha-L-rhamnopyranoside
CHEMBL596258
No. 2 No. 15
C00013329 External link 512 Tricin
/ 5,7,4'-Trihydroxy-3',5'-dimethoxyflavone
/ 5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL454320
C017769
No. 3 No. 15
C00031262 External link 512 Sachaloside III
/ (-)-Sachaloside III
No. 5 No. 15
C00000960 External link 512 Eriodictyol
CHEMBL8996
CHEMBL307893
CHEMBL1975989
C007619
32 / 29 / 55 5 / 0 No. 25 No. 14
C00031186 External link 512 Rosin
/ Rosin X
/ (-)-Rosin
/ trans-Cinnamyl beta-D-glucopyranoside
No. 45 No. 72
C00029468 External link 512 Phenethyl beta-D-glucopyranoside
/ 2-Phenylethyl beta-D-glucopyranoside
/ (-)-Phenethyl beta-D-glucopyranoside
CHEMBL510617
CHEMBL1802183
No. 45 No. 72
C00029812 External link 512 Benzyl beta-D-glucopyranoside
/ (-)-Benzyl-O-beta-D-glucopyranoside
CHEMBL1170453
CHEMBL2336738
C410942
No. 45 No. 72
C00031274 External link 512 Salidroside
/ Rhodioloside
/ (-)-Rhodioloside
/ Tyrosol alpha-(beta-D-glucopyranoside)
CHEMBL465208
CHEMBL1899113
C009172
3 / 0 / 0 No. 45 No. 72
C00008818 External link 512 Epigallocatechin
/ (-)-Epigallocatechin
CHEMBL47386
CHEMBL125743
CHEMBL130415
CHEMBL264167
CHEMBL404845
26 / 17 / 29 No. 52 No. 14
C00000674 External link 512 Luteolin
CHEMBL151
D047311
99 / 91 / 95 76 / 6 No. 71 No. 15
C00004565 External link 512 Kaempferol
/ Nimbecetin
/ Rhamnolutein
/ Pelargidenolon
/ 5,7,4'-Trihydroxyflavonol
/ 3,5,7,4'-Tetrahydroxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL150
C006552
76 / 69 / 87 86 / 8 No. 71 No. 15
C00031184 External link 512 Rosarin
No. 128 No. 72
C00031185 External link 512 Rosavin
CHEMBL1083511
1 / 1 / 1 No. 128 No. 72
C00030363 External link 512 Gein
/ Geoside
No. 128 No. 72
C00031260 External link 512 Sachaloside I
/ (-)-Sachaloside I
No. 167
C00031261 External link 512 Sachaloside II
/ (-)-Sachaloside II
No. 167
C00029424 External link 512 1-Octyl-beta-D-glucopyranoside
CHEMBL446037
CHEMBL1222151
CHEMBL1689637
CHEMBL2303841
C018619
No. 258 No. 73
C00031152 External link 512 Rhodiocyanoside A
No. 258 No. 73
C00001448 External link 512 Lotaustralin
/ (R)-Lotaustralin
C001556
No. 258 No. 73
C00031263 External link 512 Sachaloside V
/ (-)-Sachaloside V
No. 258 No. 73
C00002933 External link 512 Pentagalloyl-beta-D-glucose
/ 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose
/ (+)-1,2,3,4,6-Penta-O-galloyl-beta-D-glucose
CHEMBL127911
CHEMBL262173
CHEMBL206710
CHEMBL207164
CHEMBL382408
CHEMBL377052
CHEMBL425946
CHEMBL383306
CHEMBL207014
CHEMBL1224764
CHEMBL1500249
C013185
46 / 53 / 44 5 / 0 No. 302 No. 81
C00002486 External link 512 Nodakenin
CHEMBL459825
C471579
11 / 8 / 6 No. 399 No. 25
C00032577 External link 512 1,2,3,6-Tetra-O-galloyl-beta-D-glucose
CHEMBL449947
CHEMBL1159463
C060475
11 / 2 / 2 No. 448 No. 81
C00031158 External link 512 Rhodioloside E
/ Sachaloside VIII
/ (-)-Sachaloside VIII
No. 565 No. 73
C00030606 External link 512 Kenposide A
/ (-)-Kenposide A
/ Geranyl beta-vicianoside
C084878
No. 565 No. 73
C00031188 External link 512 Rosiridoside B
/ (-)-Rosiridoside B
No. 565 No. 73
C00031264 External link 512 Sachaloside VI
/ (-)-Sachaloside VI
No. 650
C00031189 External link 512 Rosiridoside C
No. 650
C00031265 External link 512 Sachaloside VII
/ (-)-Sachaloside VII
No. 650
C00029285 External link 512 Rosiridin
/ (-)-Rosiridol 1-O-beta-D-glucopyranoside
No. 650
C00002647 External link 512 Gallic acid
CHEMBL288114
D005707
42 / 53 / 68 52 / 16 No. 817 No. 81
C00000152 External link 512 p-Coumaric acid
CHEMBL66879
CHEMBL2336752
C032171
23 / 13 / 18 6 / 1 No. 904 No. 6
C00000580 External link 512 trans-p-Coumaric acid
/ trans-p-Hydroxycinnamic acid
CHEMBL66879
CHEMBL2336752
23 / 13 / 18 No. 904 No. 6
C00000615 External link 512 Caffeic acid
CHEMBL145
CHEMBL1320034
68 / 64 / 63 No. 904 No. 6
C00029515 External link 512 p-Tyrosol
/ 4-(2-Hydroxyethyl)phenol
/ p-Hydroxyphenethyl alcohol
/ 2-(4-Hydroxyphenyl)ethanol
CHEMBL53566
C011867
6 / 3 / 5 No. 936 No. 6
C00032375 External link 512 (E)-Cinnamic alcohol
/ trans-Cinnamyl alcohol
CHEMBL118958
CHEMBL324794
4 / 2 / 1 No. 2320 No. 6
C00033349 External link 512 Sachalinoside A
/ (-)-Sachalinoside A
No. 3482
C00033346 External link 512 Sachalinol A
No. 4476
C00033348 External link 512 Sachalinol C
/ (+)-Sachalinol C
No. 5085
C00033347 External link 512 Sachalinol B
/ (+)-Sachalinol B
No. 5085
C00033350 External link 512 Sachalinoside B
/ (-)-Sachalinoside B
No. 8111
C00031259 External link 512 Sachalol
No. 8174
C00031187 External link 512 Rosiridoside A
/ (-)-Rosiridoside A
No. 8654

Human Protein / Gene in interactions

197 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000615 C00000674 C00000960 C00002486 C00002647 C00002933 C00004565 C00008818 2 / 2
P10636 Microtubule-associated protein tau Unclassified protein C00000615 C00000674 C00000960 C00002647 C00002933 C00004565 C00008818 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000615 C00000674 C00000960 C00002647 C00002933 C00004565 C00008818 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000615 C00000674 C00000960 C00002647 C00002933 C00004565 C00008818 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000615 C00000674 C00000960 C00002486 C00002647 C00004565 C00008818 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000152 C00000580 C00000615 C00000674 C00002647 C00004565 C00008818 0 / 3
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000615 C00000674 C00004565 C00008818 C00031185 C00032375 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000615 C00000674 C00000960 C00002647 C00004565 C00008818 3 / 3
P03372 Estrogen receptor NR3A1 C00000152 C00000580 C00000615 C00000674 C00002647 C00004565 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000615 C00000674 C00002647 C00002933 C00004565 C00008818 1 / 1
P00915 Carbonic anhydrase 1 Lyase C00000152 C00000580 C00000615 C00002647 C00029515 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000615 C00000674 C00004565 C00008818 C00031274 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000615 C00000674 C00002486 C00002647 C00002933 0 / 0
P14679 Tyrosinase Oxidoreductase C00000152 C00000580 C00000615 C00000674 C00004565 4 / 2
Q9UBT6 DNA polymerase kappa Enzyme C00000615 C00000674 C00000960 C00002647 C00008818 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000615 C00000674 C00002647 C00002933 C00004565 11 / 10
P15121 Aldose reductase Enzyme C00000152 C00000580 C00000615 C00002647 C00004565 0 / 0
O75496 Geminin Unclassified protein C00000674 C00000960 C00002486 C00002933 C00031274 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000152 C00000580 C00000615 C00002647 C00029515 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000615 C00000674 C00000960 C00002647 C00029515 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000615 C00000674 C00000960 C00002486 C00002933 1 / 1
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000152 C00000580 C00000615 C00002647 C00029515 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000152 C00000580 C00000615 C00002647 C00029515 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000152 C00000580 C00000615 C00002647 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000674 C00000960 C00002933 C00008818 0 / 0
P06746 DNA polymerase beta Enzyme C00000615 C00000674 C00000960 C00002933 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000615 C00000674 C00002933 C00004565 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00000152 C00000580 C00000615 C00002647 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000674 C00000960 C00002486 C00004565 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000152 C00000580 C00000615 C00004565 1 / 8
P16050 Arachidonate 15-lipoxygenase Enzyme C00000674 C00000960 C00004565 C00008818 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000152 C00000580 C00000615 C00002647 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000615 C00000674 C00000960 C00004565 0 / 1
O43570 Carbonic anhydrase 12 Lyase C00000152 C00000580 C00000615 C00002647 1 / 2
P07451 Carbonic anhydrase 3 Lyase C00000152 C00000580 C00000615 C00002647 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000674 C00000960 C00002486 C00004565 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000152 C00000580 C00000615 C00002647 0 / 0
O00255 Menin Unclassified protein C00000615 C00000674 C00002933 C00004565 2 / 5
P04637 Cellular tumor antigen p53 Transcription Factor C00000674 C00000960 C00002647 C00004565 7 / 37
Q16790 Carbonic anhydrase 9 Lyase C00000152 C00000580 C00000615 C00002647 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000615 C00000960 C00002647 C00002933 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000615 C00000674 C00000960 C00004565 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000615 C00000674 C00000960 C00004565 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000152 C00000580 C00000615 C00002647 3 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000674 C00000960 C00004565 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000152 C00000580 C00000615 1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000674 C00002647 C00004565 0 / 0
P39748 Flap endonuclease 1 Enzyme C00000674 C00000960 C00004565 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00000674 C00002933 C00008818 1 / 4
Q13951 Core-binding factor subunit beta Unclassified protein C00000674 C00002933 C00008818 0 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00000615 C00000674 C00002933 3 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000615 C00000674 C00004565 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000615 C00000674 C00004565 0 / 1
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000152 C00000580 C00000615 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000152 C00000580 C00000615 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000674 C00000960 C00004565 1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000615 C00000674 C00004565 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000674 C00004565 C00008818 0 / 0
P04062 Glucosylceramidase Enzyme C00000674 C00002933 C00004565 6 / 4
P04150 Glucocorticoid receptor NR3C1 C00000674 C00002647 C00004565 0 / 1
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000152 C00000580 C00000615 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000674 C00000960 C00004565 4 / 4
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000152 C00000580 C00000615 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000674 C00000960 C00004565 1 / 1
P06280 Alpha-galactosidase A Enzyme C00000615 C00000674 C00002486 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000615 C00000674 C00002933 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000674 C00002647 C00002933 4 / 1
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000152 C00000580 C00000615 1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00002647 C00008818 C00029515 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000674 C00000960 C00004565 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000615 C00000674 C00004565 1 / 0
Q9Y3R4 Sialidase-2 Enzyme C00000674 C00004565 0 / 0
Q04760 Lactoylglutathione lyase Enzyme C00000674 C00004565 0 / 0
P10275 Androgen receptor NR3C4 C00000674 C00004565 3 / 4
P11473 Vitamin D3 receptor NR1I1 C00002647 C00008818 2 / 3
P11388 DNA topoisomerase 2-alpha Isomerase C00000674 C00004565 0 / 0
P54132 Bloom syndrome protein Enzyme C00000674 C00002933 1 / 2
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00000674 C00004565 0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 C00000674 C00004565 0 / 0
P08183 Multidrug resistance protein 1 drug C00000674 C00004565 1 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002647 C00002933 0 / 0
Q05513 Protein kinase C zeta type Iota C00002933 C00032577 0 / 0
Q04759 Protein kinase C theta type Delta C00002933 C00032577 0 / 1
P11309 Serine/threonine-protein kinase pim-1 Pim C00000674 C00004565 0 / 0
Q02156 Protein kinase C epsilon type Eta C00002933 C00032577 0 / 0
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00000674 C00004565 1 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00002933 C00032577 0 / 0
P56817 Beta-secretase 1 A1A C00002933 C00008818 0 / 0
P17252 Protein kinase C alpha type Alpha C00002933 C00032577 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000615 C00000674 3 / 2
Q05655 Protein kinase C delta type Delta C00002933 C00032577 0 / 0
P05129 Protein kinase C gamma type Alpha C00002933 C00032577 1 / 1
P05771 Protein kinase C beta type Alpha C00002933 C00032577 0 / 0
P24723 Protein kinase C eta type Eta C00002933 C00032577 1 / 0
P03956 Interstitial collagenase M10A C00000615 C00000674 0 / 1
P14780 Matrix metalloproteinase-9 M10A C00000615 C00000674 2 / 2
P41743 Protein kinase C iota type Iota C00002933 C00032577 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00002933 C00032577 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002486 C00002933 0 / 0
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00000674 C00004565 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00000674 C00004565 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00000674 C00000960 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00000615 C00002933 4 / 2
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000615 C00004565 2 / 2
P06493 Cyclin-dependent kinase 1 Cdc2 C00000674 C00004565 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000615 C00004565 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00000674 C00004565 2 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00000674 C00004565 0 / 0
P06276 Cholinesterase Hydrolase C00000674 C00004565 0 / 0
Q99700 Ataxin-2 Unclassified protein C00000674 C00004565 1 / 1
P04745 Alpha-amylase 1 Enzyme C00000674 C00004565 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00000674 C00004565 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000674 C00002933 2 / 0
P08253 72 kDa type IV collagenase M10A C00000615 C00000674 1 / 3
P49840 Glycogen synthase kinase-3 alpha Gsk C00000674 C00004565 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000615 C00002933 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00000674 C00004565 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00000674 C00002486 1 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00000674 C00000960 2 / 1
P10696 Alkaline phosphatase, placental-like Enzyme C00000960 0 / 1
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00000615 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00004565 0 / 0
P45452 Collagenase 3 M10A C00000674 1 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00004565 5 / 3
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00032375 1 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00002933 5 / 4
P83916 Chromobox protein homolog 1 Unclassified protein C00031274 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000615 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00004565 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000674 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00032375 0 / 0
Q9H2K2 Tankyrase-2 Enzyme C00000674 0 / 0
O14763 Tumor necrosis factor receptor superfamily member 10B Unclassified protein C00000674 1 / 0
P00374 Dihydrofolate reductase Oxidoreductase C00008818 1 / 1
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000960 3 / 1
P12821 Angiotensin-converting enzyme M2 C00002647 4 / 2
P09923 Intestinal-type alkaline phosphatase Enzyme C00000960 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00008818 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000615 0 / 0
Q12791 Calcium-activated potassium channel subunit alpha-1 KCNM, KCa1.x C00004565 1 / 1
P14151 L-selectin Adhesion C00002647 0 / 0
P16109 P-selectin Adhesion C00002647 1 / 0
P09874 Poly [ADP-ribose] polymerase 1 Enzyme C00000674 0 / 0
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00004565 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00004565 0 / 1
P98170 E3 ubiquitin-protein ligase XIAP Other cytosolic protein C00004565 1 / 1
P10145 Interleukin-8 Secreted protein C00002647 0 / 0
P00742 Coagulation factor X S1A C00002933 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00008818 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00000674 4 / 2
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00032375 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002647 5 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000674 2 / 0
P42858 Huntingtin Unclassified protein C00002933 1 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00002486 2 / 2
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00004565 0 / 0
P16581 E-selectin Adhesion C00002647 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000674 0 / 1
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00002933 0 / 1
P41145 Kappa-type opioid receptor Opioid receptor C00008818 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00004565 0 / 0
P08254 Stromelysin-1 M10A C00000674 1 / 0
P48147 Prolyl endopeptidase S9A C00004565 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00000674 0 / 0
Q12794 Hyaluronidase-1 Enzyme C00000615 1 / 2
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00008818 0 / 7
Q9GZU7 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Enzyme C00004565 0 / 0
P24298 Alanine aminotransferase 1 Enzyme C00000615 0 / 0
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor C00000674 0 / 0
P51570 Galactokinase Enzyme C00000674 1 / 1
Q9GZT9 Egl nine homolog 1 Enzyme C00000615 1 / 1
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00002933 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00000674 0 / 0
P49327 Fatty acid synthase Transferase C00000674 0 / 0
P78536 Disintegrin and metalloproteinase domain-containing protein 17 M12B C00002647 1 / 0
P03951 Coagulation factor XI S1A C00002933 1 / 1
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00000615 0 / 0
P02768 Serum albumin Secreted protein C00008818 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000674 1 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00004565 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002933 0 / 0
O95271 Tankyrase-1 Enzyme C00000674 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00000674 0 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000674 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00004565 0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00008818 0 / 0
P39900 Macrophage metalloelastase M10A C00000674 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002647 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00000674 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00000960 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00000615 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00000615 0 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002933 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00004565 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00004565 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00004565 0 / 0
Q15046 Lysine--tRNA ligase Enzyme C00000674 2 / 1

156 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000152 C00000674 C00002647 C00004565
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000674 C00002647 C00002933 C00004565
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000674 C00002933 C00004565
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000674 C00002647 C00004565
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000674 C00002647 C00004565
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000674 C00002647 C00004565
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000674 C00000960 C00004565
581 BAX, BCL2L4 BCL2-associated X protein C00000674 C00002647 C00004565
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000674 C00002647 C00002933
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000674 C00002647 C00004565
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000152 C00000674 C00004565
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000674 C00002647 C00004565
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000674 C00002647 C00004565
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000152 C00002647
891 CCNB1, CCNB cyclin B1 C00000674 C00004565
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00000674 C00004565
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000674 C00004565
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00000674 C00004565
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00000674 C00002647
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00002647 C00004565
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000674 C00002647
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00000674 C00004565
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000674 C00002647
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002647 C00004565
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00000674 C00004565
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000152 C00004565
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000674 C00004565
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000674 C00002647
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000674 C00004565
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00000674 C00002647
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000674 C00004565
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000674 C00004565
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00000674 C00004565
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00000674 C00004565
4616 GADD45B, GADD45BETA, MYD118 growth arrest and DNA-damage-inducible, beta C00000674 C00004565
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00000674 C00002933
4793 NFKBIB, IKBB, TRIP9 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta C00000674 C00002647
29110 TBK1, NAK, T2K TANK-binding kinase 1 (EC:2.7.11.1) C00000674 C00000960
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00000960 C00004565
8839 WISP2, CCN5, CT58, CTGF-L WNT1 inducible signaling pathway protein 2 C00000674 C00004565
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00000674 C00004565
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000674 C00004565
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00002647 C00004565
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000674 C00004565
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00000674 C00004565
7161 TP73, P73 tumor protein p73 C00000674 C00004565
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002647 C00004565
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00000674 C00004565
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00000674 C00004565
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00000674 C00002647
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00000674 C00002647
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00000674 C00004565
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002647 C00004565
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000674 C00004565
2810 SFN, YWHAS stratifin C00000674 C00004565
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002647 C00004565
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000960 C00004565
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000674 C00004565
8000 PSCA, PRO232 prostate stem cell antigen C00000674 C00004565
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC:2.7.11.13) C00002647
9970 NR1I3, CAR, CAR1, MB67 nuclear receptor subfamily 1, group I, member 3 C00004565
5241 PGR, NR3C3, PR progesterone receptor C00004565
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00004565
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00004565
8202 NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP nuclear receptor coactivator 3 (EC:2.3.1.48) C00004565
6119 RPA3, REPA3 replication protein A3, 14kDa C00004565
4586 MUC5AC, MUC5, TBM, leB mucin 5AC, oligomeric mucus/gel-forming C00004565
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00004565
6773 STAT2, ISGF-3, P113, STAT113 signal transducer and activator of transcription 2, 113kDa C00004565
7019 TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 transcription factor A, mitochondrial C00004565
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00004565
7039 TGFA, TFGA transforming growth factor, alpha C00004565
4502 MT2A, MT2 metallothionein 2A C00004565
110357 C00004565
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00004565
4297 KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS lysine (K)-specific methyltransferase 2A (EC:2.1.1.43) C00004565
3567 IL5, EDF, IL-5, TRF interleukin 5 (colony-stimulating factor, eosinophil) C00004565
7352 UCP3, SLC25A9 uncoupling protein 3 (mitochondrial, proton carrier) C00004565
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00004565
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00004565
3043 HBB, CD113t-C, beta-globin hemoglobin, beta C00004565
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00004565
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00004565
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00004565
7402 UTRN, DMDL, DRP, DRP1 utrophin C00004565
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00004565
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000960
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00004565
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002933
9687 GREB1 growth regulation by estrogen in breast cancer 1 C00004565
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00004565
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000152
1734 DIO2, 5DII, D2, DIOII, SelY, TXDI2 deiodinase, iodothyronine, type II (EC:1.97.1.10) C00004565
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00000152
25 ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) C00002647
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00002647
545 ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 ataxia telangiectasia and Rad3 related (EC:2.7.11.1) C00002647
613 BCR, ALL, BCR1, CML, D22S11, D22S662, PHL breakpoint cluster region (EC:2.7.11.1) C00002647
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00004565
898 CCNE1, CCNE cyclin E1 C00002647
998 CDC42, CDC42Hs, G25K cell division cycle 42 C00002647
37618 C00004565
7852 CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM chemokine (C-X-C motif) receptor 4 C00002647
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00002647
2551 GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 GA binding protein transcription factor, alpha subunit 60kDa C00002647
2885 GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 growth factor receptor-bound protein 2 C00002647
3551 IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) C00002647
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002647
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00002647
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00002647
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00004565
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00004565
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00002647
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002647
4316 MMP7, MMP-7, MPSL1, PUMP-1 matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) C00002647
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00004565
27113 BBC3, JFY-1, JFY1, PUMA BCL2 binding component 3 C00004565
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00004565
5591 PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) C00002647
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00002647
19412 C00002647
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00002647
388 RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 ras homolog family member B C00002647
6195 RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) C00002647
9252 RPS6KA5, MSK1, MSPK1, RLPK ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) C00002647
6622 SNCA, NACP, PARK1, PARK4, PD1 synuclein, alpha (non A4 component of amyloid precursor) C00002647
7224 TRPC5, TRP5 transient receptor potential cation channel, subfamily C, member 5 C00002647
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00004565
239 ALOX12, 12-LOX, 12S-LOX, LOG12 arachidonate 12-lipoxygenase (EC:1.13.11.31) C00004565
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00000674
177 AGER, RAGE advanced glycosylation end product-specific receptor C00000674
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00000674
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00000674
847 CAT catalase (EC:1.11.1.6) C00000674
890 CCNA2, CCN1, CCNA cyclin A2 C00000674
958 CD40, Bp50, CDW40, TNFRSF5, p50 CD40 molecule, TNF receptor superfamily member 5 C00000674
972 CD74, DHLAG, HLADG, II, Ia-GAMMA CD74 molecule, major histocompatibility complex, class II invariant chain C00000674
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00000674
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00000674
1950 EGF, HOMG4, URG epidermal growth factor C00000674
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00000674
1958 EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 early growth response 1 C00000674
2354 FOSB, AP-1, G0S3, GOS3, GOSB FBJ murine osteosarcoma viral oncogene homolog B C00000674
3726 JUNB, AP-1 jun B proto-oncogene C00000674
3727 JUND, AP-1 jun D proto-oncogene C00000674
5602 MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK mitogen-activated protein kinase 10 (EC:2.7.11.24) C00000674
4312 MMP1, CLG, CLGN matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) C00000674
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00000674
9572 NR1D1, EAR1, THRA1, THRAL, ear-1, hRev nuclear receptor subfamily 1, group D, member 1 C00000674
5347 PLK1, PLK, STPK13 polo-like kinase 1 (EC:2.7.11.21) C00000674
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00000674
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00000674
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00000674
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00000674
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00000674
10451 VAV3 vav 3 guanine nucleotide exchange factor C00000674

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (148)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#600807 Asthma, susceptibility to Q13093
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P18054
P84022
Q14191
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#227600 Factor x deficiency P00742
#612416 Factor xi deficiency P03951
#600274 Frontotemporal dementia; ftd P10636
#230200 Galactokinase deficiency P51570
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#609446 Generalized epilepsy and paroxysmal dyskinesia; gepd Q12791
#143500 Gilbert syndrome P22309
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#114550 Hepatocellular carcinoma P08581
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#614328 Inflammatory skin and bowel disease, neonatal; nisbd P78536
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04637
#300635 Lymphoproliferative syndrome, x-linked, 2; xlp2 P98170
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#163950 Noonan syndrome 1; ns1 Q06124
#601665 Obesity P37231
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#267430 Renal tubular dysgenesis; rtd P12821
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#275355 Squamous cell carcinoma, head and neck; hnscc O14763
P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601367 Stroke, ischemic P12821
P16109
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (130)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04637 (related)
P08581 (related)
P10415 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04637 (related)
P08253 (related)
P10415 (related)
H00030 Cervical cancer P00533 (related)
P10415 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
Q15046 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00938 Factor XI deficiency P03951 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P10415 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
P10415 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P27487 (marker)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
P10415 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P08581 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00408 Type I diabetes mellitus P17706 (related)
Q04759 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00192 Xanthinuria P47989 (related)
H00070 Galactosemia P51570 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00107 Other well-defined immunodeficiency syndromes P98170 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H01258 Generalized epilepsy and paroxysmal dyskinesia (GEPD) Q12791 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

29 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009202 Cardiomyopathies C00004565
C00000674
D006943 Hyperglycemia C00004565
C00002647
D006949 Hyperlipidemias C00002647
D002318 Cardiovascular Diseases C00004565
D001943 Breast Neoplasms C00004565
D007938 Leukemia C00004565
D010024 Osteoporosis C00004565
D011297 Prenatal Exposure Delayed Effects C00004565
D008545 Melanoma C00000152
D003921 Diabetes Mellitus, Experimental C00002647
D050171 Dyslipidemias C00002647
D005234 Fatty Liver C00002647
D018149 Glucose Intolerance C00002647
D006937 Hypercholesterolemia C00002647
D050197 Atherosclerosis C00004565
D015228 Hypertriglyceridemia C00002647
D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive C00002647
D008546 Melanoma, Experimental C00002647
D009069 Movement Disorders C00002647
D009203 Myocardial Infarction C00002647
D009361 Neoplasm Invasiveness C00002647
D009362 Neoplasm Metastasis C00002647
D012516 Osteosarcoma C00002647
D010182 Pancreatic Diseases C00002647
D002386 Cataract C00000674
D005483 Flushing C00000674
D006529 Hepatomegaly C00000674
D008103 Liver Cirrhosis C00000674
D010051 Ovarian Neoplasms C00000674