PCIDB

KNApSAcK Metabolite C00000674

Metabolite

KNApSAcK Entry

id C00000674
Name Luteolin
CAS RN 491-70-3
Standard InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
Standard InChI (Main Layer) InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 71

Link

ChEMBL

By standard InChI CHEMBL151
By standard InChI Main Layer CHEMBL151

KEGG

By LinkDB C01514

CTD

By CAS RN D047311

Species

Summary

Plant class

class name count
rosids 134
asterids 44
eudicotyledons 18
Liliopsida 5
Magnoliophyta 2
Euphyllophyta 1
Spermatophyta 1

Family (Top 10)

family name count
Fabaceae 128
Lamiaceae 21
Berberidaceae 14
Asteraceae 11
Crassulaceae 3
Convolvulaceae 2
Resedaceae 2
Juncaceae 2
Scrophulariaceae 2
Campanulaceae 2

List (206)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Abrus precatorius 3816 Fabaceae rosids Viridiplantae
Acacia aroma 207708 Fabaceae rosids Viridiplantae
Acacia caven 72367 Fabaceae rosids Viridiplantae
Acacia furcatispina 370701 Fabaceae rosids Viridiplantae
Acacia leucophloea 1217422 Fabaceae rosids Viridiplantae
Acacia praecox 3808 Fabaceae rosids Viridiplantae
Ajuga decumbens 167911 Lamiaceae asterids Viridiplantae
Apium graveolens 4045 Apiaceae asterids Viridiplantae
Artabotrys uncinatus 225832 Annonaceae Magnoliophyta Viridiplantae
Artemisia minor 1227633 Asteraceae asterids Viridiplantae
Astragalus coluteocarpus 339481 Fabaceae rosids Viridiplantae
Astragalus eremophilus 144098 Fabaceae rosids Viridiplantae
Astragalus kabadianus 20400 Fabaceae rosids Viridiplantae
Astragalus quisqualis 20400 Fabaceae rosids Viridiplantae
Baptisia arachnifera 49796 Fabaceae rosids Viridiplantae
Baptisia australis 149633 Fabaceae rosids Viridiplantae
Baptisia bracteata 313912 Fabaceae rosids Viridiplantae
Baptisia calycosa 49796 Fabaceae rosids Viridiplantae
Baptisia cinerea 313913 Fabaceae rosids Viridiplantae
Baptisia lanceolata 49796 Fabaceae rosids Viridiplantae
Baptisia lecontei 49796 Fabaceae rosids Viridiplantae
Baptisia megacarpa 49796 Fabaceae rosids Viridiplantae
Baptisia nuttalliana 49796 Fabaceae rosids Viridiplantae
Baptisia perfoliata 49796 Fabaceae rosids Viridiplantae
Baptisia simplicifolia 49796 Fabaceae rosids Viridiplantae
Baptisia sphaerocarpa 313914 Fabaceae rosids Viridiplantae
Baptisia tinctoria 49797 Fabaceae rosids Viridiplantae
Biebersteinia orphanidis 74351 Biebersteiniaceae rosids Viridiplantae
Cadia purpurea 53844 Fabaceae rosids Viridiplantae
Caesalpinia gilliesii 191891 Fabaceae rosids Viridiplantae
Capparis himalayensis 13394 Capparaceae rosids Viridiplantae
Capsicum annum L. 4071 Solanaceae asterids Viridiplantae
Centaurea bracteata Scop. 41503 Asteraceae asterids Viridiplantae
Chamaecrista absus 592576 Fabaceae rosids Viridiplantae
Chamaecrista mimosoides 948715 Fabaceae rosids Viridiplantae
Chrysanthemum cineraiaefolium 13422 Asteraceae asterids Viridiplantae
Chrysanthemum indicum 146995 Asteraceae asterids Viridiplantae
Codonopsis clematidea 942849 Campanulaceae asterids Viridiplantae
Codonopsis tangshen OLIV. 94284 Campanulaceae asterids Viridiplantae
Crotalaria pallida 3830 Fabaceae rosids Viridiplantae
Cytisophyllum sessilifolium 3834 Fabaceae rosids Viridiplantae
Cytisus eriocarpus 3833 Fabaceae rosids Viridiplantae
Cytisus hirsutus 1211454 Fabaceae rosids Viridiplantae
Cytisus proliferus 49805 Fabaceae rosids Viridiplantae
Cytisus striatus 176342 Fabaceae rosids Viridiplantae
Elsholtzia bodinieri 41225 Lamiaceae asterids Viridiplantae
Elsholtzia rugulosa Hemsl. 41225 Lamiaceae asterids Viridiplantae
Epimedium acuminatum 253612 Berberidaceae eudicotyledons Viridiplantae
Epimedium brevicornum 253618 Berberidaceae eudicotyledons Viridiplantae
Epimedium dolichostemen 63350 Berberidaceae eudicotyledons Viridiplantae
Epimedium fargesii 402155 Berberidaceae eudicotyledons Viridiplantae
Epimedium franchetii 253603 Berberidaceae eudicotyledons Viridiplantae
Epimedium koreanum 63351 Berberidaceae eudicotyledons Viridiplantae
Epimedium leishanense 1175245 Berberidaceae eudicotyledons Viridiplantae
Epimedium leptorrhizum 253609 Berberidaceae eudicotyledons Viridiplantae
Epimedium membranaceum 402159 Berberidaceae eudicotyledons Viridiplantae
Epimedium myrianthum 402161 Berberidaceae eudicotyledons Viridiplantae
Epimedium pubescens 153729 Berberidaceae eudicotyledons Viridiplantae
Epimedium sagittatum 253616 Berberidaceae eudicotyledons Viridiplantae
Epimedium zhenbaense 589479 Berberidaceae eudicotyledons Viridiplantae
Epimedium zhushanense 589477 Berberidaceae eudicotyledons Viridiplantae
Erycibe expansa 197385 Convolvulaceae asterids Viridiplantae
Erythrophleum suaveolens 162772 Fabaceae rosids Viridiplantae
Ficus cordata 309266 Moraceae rosids Viridiplantae
Galega officinalis 47101 Fabaceae rosids Viridiplantae
Genista acanthoclada 274560 Fabaceae rosids Viridiplantae
Genista carpetana 238478 Fabaceae rosids Viridiplantae
Genista corsica 319660 Fabaceae rosids Viridiplantae
Genista depressa 49818 Fabaceae rosids Viridiplantae
Genista ferox 49818 Fabaceae rosids Viridiplantae
Genista januensis 49824 Fabaceae rosids Viridiplantae
Genista lydia 529822 Fabaceae rosids Viridiplantae
Genista morisii 49818 Fabaceae rosids Viridiplantae
Genista nissana 136805 Fabaceae rosids Viridiplantae
Genista obtusiramea 238500 Fabaceae rosids Viridiplantae
Genista pilosa 238501 Fabaceae rosids Viridiplantae
Genista sagittalis 49809 Fabaceae rosids Viridiplantae
Genista scorpius 238509 Fabaceae rosids Viridiplantae
Genista spartioides 123911 Fabaceae rosids Viridiplantae
Genista stenopetala 49851 Fabaceae rosids Viridiplantae
Genista teretifolia 238513 Fabaceae rosids Viridiplantae
Genista tinctoria 49825 Fabaceae rosids Viridiplantae
Genista triacanthos 238516 Fabaceae rosids Viridiplantae
Genista versicolor 238524 Fabaceae rosids Viridiplantae
Gentiana arisanensis 1169730 Gentianaceae asterids Viridiplantae
Gleditsia australis 66089 Fabaceae rosids Viridiplantae
Gleditsia triacanthos 54874 Fabaceae rosids Viridiplantae
Gonocytisus angulatus 449083 Fabaceae rosids Viridiplantae
Halophila johnsonii 180125 Hydrocharitaceae Liliopsida Viridiplantae
Hesperolaburnum platycarpum 238526 Fabaceae rosids Viridiplantae
Inula britannica 119176 Asteraceae asterids Viridiplantae
Juncus effusus 13579 Juncaceae Liliopsida Viridiplantae
Lathyrus pratensis 254779 Fabaceae rosids Viridiplantae
Leiothrix curvifolia 446055 Eriocaulaceae Liliopsida Viridiplantae
Lens culinaris 3864 Fabaceae rosids Viridiplantae
Leontodon autumnalis 212686 Asteraceae asterids Viridiplantae
Lippia sidoides 320357 Verbenaceae asterids Viridiplantae
Lonicera japonica 105884 Caprifoliaceae asterids Viridiplantae
Lupinus arboreus 3872 Fabaceae rosids Viridiplantae
Lupinus polyphyllus 3874 Fabaceae rosids Viridiplantae
Lupinus sericeus 61075 Fabaceae rosids Viridiplantae
Luzula multiflora 178423 Juncaceae Liliopsida Viridiplantae
Lychnis flos-cuculi L. 42036 Caryophyllaceae eudicotyledons Viridiplantae
Machilus philippinensis 337469 Lauraceae Magnoliophyta Viridiplantae
Medicago coronata 66811 Fabaceae rosids Viridiplantae
Medicago laciniata 70952 Fabaceae rosids Viridiplantae
Medicago littoralis 75626 Fabaceae rosids Viridiplantae
Medicago marina 66815 Fabaceae rosids Viridiplantae
Medicago minima 70957 Fabaceae rosids Viridiplantae
Medicago orbicularis 70962 Fabaceae rosids Viridiplantae
Medicago sativa 3879 Fabaceae rosids Viridiplantae
Merremia tridentata 89667 Convolvulaceae asterids Viridiplantae
Myoporum bontioides 57115 Scrophulariaceae asterids Viridiplantae
Notholaena californica 414628 Pteridaceae Euphyllophyta Viridiplantae
Ocimum americanum L.var.pilosum (Willd.) Paton 39173 Lamiaceae asterids Viridiplantae
Ocimum basilicum L. 39350 Lamiaceae asterids Viridiplantae
Ocimum x citriodorum Vis. 204098 Lamiaceae asterids Viridiplantae
Ononis spinosa 58890 Fabaceae rosids Viridiplantae
Parkinsonia aculeata 58886 Fabaceae rosids Viridiplantae
Pentemon gentianoides HBK
Picris cyanocarpa 122541 Asteraceae asterids Viridiplantae
Picris kamtschatica 122541 Asteraceae asterids Viridiplantae
Podocarpus fasciculus 120615 Podocarpaceae Spermatophyta Viridiplantae
Podocytisus caramanicus 359571 Fabaceae rosids Viridiplantae
Prosopis affinis 207709 Fabaceae rosids Viridiplantae
Prosopis alba 207710 Fabaceae rosids Viridiplantae
Prosopis argentina 207712 Fabaceae rosids Viridiplantae
Prosopis chilensis 35716 Fabaceae rosids Viridiplantae
Prosopis flexuosa 207714 Fabaceae rosids Viridiplantae
Prosopis glandulosa 102697 Fabaceae rosids Viridiplantae
Prosopis juliflora 13230 Fabaceae rosids Viridiplantae
Prosopis laevigata 364022 Fabaceae rosids Viridiplantae
Prosopis nigra 207716 Fabaceae rosids Viridiplantae
Prosopis reptans 207717 Fabaceae rosids Viridiplantae
Prosopis ruscifolia 207718 Fabaceae rosids Viridiplantae
Prosopis sericantha 433933 Fabaceae rosids Viridiplantae
Prosopis strombulifera 433934 Fabaceae rosids Viridiplantae
Prosopis velutina 207719 Fabaceae rosids Viridiplantae
Prosopis vinalillo 207720 Fabaceae rosids Viridiplantae
Reseda luteola 415813 Resedaceae rosids Viridiplantae
Reseda muricata C.Presl. 26963 Resedaceae rosids Viridiplantae
Rhaponticum carthamoides 362630 Asteraceae asterids Viridiplantae
Rhodiola sachalinensis 265354 Crassulaceae eudicotyledons Viridiplantae
Rhynchosia suaveolens 132460 Fabaceae rosids Viridiplantae
Salvia aegyptiaca 392645 Lamiaceae asterids Viridiplantae
Salvia albimaculata 21880 Lamiaceae asterids Viridiplantae
Salvia dorrii 207754 Lamiaceae asterids Viridiplantae
Salvia horminum 21880 Lamiaceae asterids Viridiplantae
Salvia hypoleuca 1294397 Lamiaceae asterids Viridiplantae
Salvia lavandulaefolia 49214 Lamiaceae asterids Viridiplantae
Salvia lavandulifolia 49214 Lamiaceae asterids Viridiplantae
Salvia limbata 21880 Lamiaceae asterids Viridiplantae
Salvia nutans 21880 Lamiaceae asterids Viridiplantae
Salvia officinalis 38868 Lamiaceae asterids Viridiplantae
Salvia palaestina 268920 Lamiaceae asterids Viridiplantae
Salvia pedicellata 21880 Lamiaceae asterids Viridiplantae
Salvia pinnata 21880 Lamiaceae asterids Viridiplantae
Salvia pratensis 49216 Lamiaceae asterids Viridiplantae
Saussurea medusa 137893 Asteraceae asterids Viridiplantae
Sedum takesimense Nakai 904691 Crassulaceae eudicotyledons Viridiplantae
Senna didymobotrya 72401 Fabaceae rosids Viridiplantae
Senna siamea 346999 Fabaceae rosids Viridiplantae
Sideritis argosphacelus var. spicata 155231 Lamiaceae asterids Viridiplantae
Sinocrassula indica 91157 Crassulaceae eudicotyledons Viridiplantae
Smilax riparia 299599 Smilacaceae Liliopsida Viridiplantae
Sonneratia caseolaris 122814 Lythraceae rosids Viridiplantae
Sophora microphylla 70607 Fabaceae rosids Viridiplantae
Sophora prostrata 76398 Fabaceae rosids Viridiplantae
Syringa afghanica 24208 Oleaceae asterids Viridiplantae
Thermopsis dolichocarpa 49852 Fabaceae rosids Viridiplantae
Thermopsis macrophylla 114322 Fabaceae rosids Viridiplantae
Thermopsis mollis 49852 Fabaceae rosids Viridiplantae
Thermopsis rhombifolia 61122 Fabaceae rosids Viridiplantae
Thermopsis villosa 114325 Fabaceae rosids Viridiplantae
Trifolium pannonicum 97032 Fabaceae rosids Viridiplantae
Trifolium subterraneum 3900 Fabaceae rosids Viridiplantae
Trigonella foenum-graecum 78534 Fabaceae rosids Viridiplantae
Verbascum sinaiticum 39257 Scrophulariaceae asterids Viridiplantae
Vernonia pectoralis 13753 Asteraceae asterids Viridiplantae
Vicia acutifolia 1276805 Fabaceae rosids Viridiplantae
Vicia americana 200966 Fabaceae rosids Viridiplantae
Vicia articulata 200967 Fabaceae rosids Viridiplantae
Vicia balansae 3904 Fabaceae rosids Viridiplantae
Vicia benghalensis 154497 Fabaceae rosids Viridiplantae
Vicia ciceroidea 3904 Fabaceae rosids Viridiplantae
Vicia cracca 3905 Fabaceae rosids Viridiplantae
Vicia dumetorum 287754 Fabaceae rosids Viridiplantae
Vicia epetiolaris 1042217 Fabaceae rosids Viridiplantae
Vicia ervilia 154498 Fabaceae rosids Viridiplantae
Vicia floridana 1276822 Fabaceae rosids Viridiplantae
Vicia glauca 1276824 Fabaceae rosids Viridiplantae
Vicia hirsuta 3910 Fabaceae rosids Viridiplantae
Vicia michauxii 173235 Fabaceae rosids Viridiplantae
Vicia minutiflora 1276835 Fabaceae rosids Viridiplantae
Vicia mollis 233249 Fabaceae rosids Viridiplantae
Vicia monantha 650620 Fabaceae rosids Viridiplantae
Vicia multijuga 3904 Fabaceae rosids Viridiplantae
Vicia ochroleuca 1276839 Fabaceae rosids Viridiplantae
Vicia onobrychioides 1276840 Fabaceae rosids Viridiplantae
Vicia pannonica 29753 Fabaceae rosids Viridiplantae
Vicia pinetorum 1276845 Fabaceae rosids Viridiplantae
Vicia sicula 1276849 Fabaceae rosids Viridiplantae
Vicia splendens 3904 Fabaceae rosids Viridiplantae
Vicia sylvatica 287755 Fabaceae rosids Viridiplantae
Vicia tenuifolia 1042229 Fabaceae rosids Viridiplantae
Vigna trilobata 87086 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

99 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL151 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL151 CHEMBL1613992 (1) CHEMBL1613995 (2)
CHEMBL1738132 (1)
7 / 44
Q9NPH5 NADPH oxidase 4 Enzyme CHEMBL151 CHEMBL1249157 (1) CHEMBL1249158 (1)
CHEMBL1249160 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL151 CHEMBL1613842 (1)
4 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL151 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL151 CHEMBL2114784 (2)
1 / 1
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL151 CHEMBL1071606 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL151 CHEMBL1014030 (1) CHEMBL1014033 (1)
CHEMBL1014037 (1) CHEMBL1014038 (1)
CHEMBL1008559 (1)
0 / 3
P06746 DNA polymerase beta Enzyme CHEMBL151 CHEMBL1614079 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL151 CHEMBL1613818 (2)
6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL151 CHEMBL1614076 (1)
1 / 1
P39900 Macrophage metalloelastase M10A CHEMBL151 CHEMBL2051216 (1) CHEMBL2051222 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL151 CHEMBL2051215 (1) CHEMBL2051221 (1)
2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL151 CHEMBL1794585 (1)
0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme CHEMBL151 CHEMBL1285540 (1) CHEMBL1799589 (1)
0 / 1
O95271 Tankyrase-1 Enzyme CHEMBL151 CHEMBL2341188 (2)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL151 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL151 CHEMBL1614361 (1)
3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL151 CHEMBL1023248 (1) CHEMBL1101617 (1)
1 / 1
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL151 CHEMBL1613776 (1)
3 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL151 CHEMBL1071605 (1)
1 / 1
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family CHEMBL151 CHEMBL832923 (1)
1 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL151 CHEMBL862675 (1) CHEMBL862676 (1)
CHEMBL926333 (1)
0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL151 CHEMBL1225717 (1) CHEMBL1780345 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL151 CHEMBL2076249 (1)
1 / 0
P49327 Fatty acid synthase Transferase CHEMBL151 CHEMBL862461 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL151 CHEMBL897015 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL151 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
Q00535 Cyclin-dependent kinase 5 Cdk5 CHEMBL151 CHEMBL876996 (1)
0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family CHEMBL151 CHEMBL876996 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL151 CHEMBL1614067 (3)
1 / 2
P51570 Galactokinase Enzyme CHEMBL151 CHEMBL1613821 (1)
1 / 1
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor CHEMBL151 CHEMBL2039370 (1) CHEMBL2039371 (1)
CHEMBL2039372 (1) CHEMBL2039373 (1)
CHEMBL2039374 (1) CHEMBL2039375 (1)
CHEMBL2039376 (1) CHEMBL2039377 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL151 CHEMBL1614166 (1)
1 / 0
P11387 DNA topoisomerase 1 Isomerase CHEMBL151 CHEMBL920762 (1) CHEMBL920763 (1)
CHEMBL920764 (1) CHEMBL920765 (1)
CHEMBL920772 (1) CHEMBL920776 (1)
0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL151 CHEMBL920766 (1) CHEMBL920767 (1)
CHEMBL920768 (1) CHEMBL920769 (1)
CHEMBL919312 (1) CHEMBL919313 (1)
0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL151 CHEMBL1008560 (1)
0 / 0
Q9Y3R4 Sialidase-2 Enzyme CHEMBL151 CHEMBL1100507 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL151 CHEMBL1613800 (2)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL151 CHEMBL1614458 (2)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL151 CHEMBL2342404 (1)
1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL151 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL151 CHEMBL1794486 (2)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL151 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL151 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL151 CHEMBL2114807 (1)
4 / 2
P09874 Poly [ADP-ribose] polymerase 1 Enzyme CHEMBL151 CHEMBL2341185 (2)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL151 CHEMBL2051212 (1)
0 / 1
Q9Y253 DNA polymerase eta Enzyme CHEMBL151 CHEMBL1794569 (1)
1 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL151 CHEMBL1963893 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL151 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL151 CHEMBL1052488 (1) CHEMBL1052489 (1)
0 / 1
P14679 Tyrosinase Oxidoreductase CHEMBL151 CHEMBL814347 (1)
4 / 2
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL151 CHEMBL1225718 (1) CHEMBL1780346 (1)
4 / 4
P06276 Cholinesterase Hydrolase CHEMBL151 CHEMBL1045780 (1)
0 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL151 CHEMBL1614217 (1)
1 / 1
P04745 Alpha-amylase 1 Enzyme CHEMBL151 CHEMBL964479 (2)
0 / 0
P45452 Collagenase 3 M10A CHEMBL151 CHEMBL2051217 (1) CHEMBL2051223 (1)
1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL151 CHEMBL1614252 (2)
2 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL151 CHEMBL1225716 (1) CHEMBL1741322 (1)
0 / 0
P08253 72 kDa type IV collagenase M10A CHEMBL151 CHEMBL2051213 (1) CHEMBL2051219 (1)
1 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL151 CHEMBL1613910 (1) CHEMBL1614227 (2)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL151 CHEMBL1694230 (1) CHEMBL2076243 (1)
CHEMBL2076821 (1)
2 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL151 CHEMBL1614038 (1)
2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL151 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
Q9H2K2 Tankyrase-2 Enzyme CHEMBL151 CHEMBL2341186 (2)
0 / 0
O14763 Tumor necrosis factor receptor superfamily member 10B Unclassified protein CHEMBL151 CHEMBL1693928 (1)
1 / 0
P03372 Estrogen receptor NR3A1 CHEMBL151 CHEMBL999944 (1)
1 / 1
P22303 Acetylcholinesterase Hydrolase CHEMBL151 CHEMBL1045781 (1)
1 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL151 CHEMBL1614240 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL151 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL151 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL151 CHEMBL1794483 (2)
0 / 0
Q15046 Lysine--tRNA ligase Enzyme CHEMBL151 CHEMBL2173401 (1) CHEMBL2173408 (1)
2 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL151 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL151 CHEMBL1614211 (4)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL151 CHEMBL1614421 (2) CHEMBL1614502 (2)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL151 CHEMBL1738184 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL151 CHEMBL1052486 (1)
3 / 4
P06239 Tyrosine-protein kinase Lck Src CHEMBL151 CHEMBL941407 (1)
0 / 1
Q04760 Lactoylglutathione lyase Enzyme CHEMBL151 CHEMBL967534 (1)
0 / 0
P08254 Stromelysin-1 M10A CHEMBL151 CHEMBL2051214 (1) CHEMBL2051220 (1)
1 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL151 CHEMBL1794536 (5)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL151 CHEMBL1613914 (3)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL151 CHEMBL1613829 (4) CHEMBL1613928 (1)
CHEMBL1794433 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL151 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL151 CHEMBL1614364 (2)
1 / 1
O00255 Menin Unclassified protein CHEMBL151 CHEMBL1614257 (3) CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL151 CHEMBL1614257 (3) CHEMBL1614531 (2)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL151 CHEMBL1613933 (2)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL151 CHEMBL1613933 (2)
1 / 6
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein CHEMBL151 CHEMBL832848 (1)
0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein CHEMBL151 CHEMBL832848 (1)
0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 CHEMBL151 CHEMBL832848 (1)
0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein CHEMBL151 CHEMBL832848 (1)
0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk CHEMBL151 CHEMBL832706 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL151 CHEMBL832706 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL151 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL151 CHEMBL2114796 (1)
2 / 1

CTD interaction (152)

compound gene gene name gene description interaction interaction type form reference
pmid
D047311 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Luteolin results in decreased activity of ABCC1 protein decreases activity
protein 15670588
D047311 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 Luteolin affects the activity of ABCG2 protein affects activity
protein 20403331
D047311 177 AGER
RAGE
advanced glycosylation end product-specific receptor Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA] decreases reaction
/ increases expression
mRNA 19557821
D047311 196 AHR
bHLHe76
aryl hydrocarbon receptor Luteolin binds to and results in decreased activity of AHR protein affects binding
/ decreases activity
protein 14644660
D047311 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 22926442
D047311 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Luteolin results in decreased expression of AKT1 protein decreases expression
protein 22926442
D047311 581 BAX
BCL2L4
BCL2-associated X protein Luteolin results in increased expression of BAX protein increases expression
protein 21601631
D047311 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
/ increases degradation
protein 19557821
D047311 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Luteolin results in decreased expression of BCL2L1 protein decreases expression
protein 21601631
D047311 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 Luteolin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] decreases reaction
/ increases expression
protein 15334063
D047311 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 16140950
D047311 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Luteolin results in increased activity of CASP3 protein increases activity
protein 21074525
21601631
D047311 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Luteolin results in increased cleavage of CASP3 protein increases cleavage
protein 18331776
19397994
D047311 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Luteolin results in increased activity of CASP7 protein increases activity
protein 21074525
D047311 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Luteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein] increases activity
/ increases cleavage
/ increases reaction
protein 15334063
D047311 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein] increases activity
/ increases reaction
protein 16140950
D047311 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Luteolin results in increased activity of CASP9 protein increases activity
protein 21601631
D047311 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Luteolin results in increased cleavage of CASP9 protein increases cleavage
protein 18331776
19397994
D047311 847 CAT
catalase (EC:1.11.1.6) Luteolin affects the activity of CAT protein affects activity
protein 18503759
D047311 890 CCNA2
CCN1
CCNA
cyclin A2 Luteolin results in decreased expression of CCNA2 protein decreases expression
protein 22926442
D047311 891 CCNB1
CCNB
cyclin B1 Luteolin results in decreased expression of CCNB1 mRNA decreases expression
mRNA 18331776
19397994
D047311 891 CCNB1
CCNB
cyclin B1 Luteolin results in decreased expression of CCNB1 protein decreases expression
protein 18331776
19397994
22926442
D047311 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] affects cotreatment
/ decreases reaction
/ increases expression
protein 16601352
D047311 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 Luteolin inhibits the reaction [Calcimycin results in increased expression of CD40 protein] decreases reaction
/ increases expression
protein 16601352
D047311 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 Luteolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD40 protein] decreases reaction
/ increases expression
protein 16601352
D047311 972 CD74
DHLAG
HLADG
II
Ia-GAMMA
CD74 molecule, major histocompatibility complex, class II invariant chain Luteolin results in decreased expression of CD74 mRNA decreases expression
mRNA 18818744
D047311 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Luteolin results in decreased expression of CDK1 protein decreases expression
protein 22926442
D047311 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Luteolin results in decreased activity of CDK2 protein decreases activity
protein 11322924
D047311 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Luteolin results in decreased expression of CDK2 protein decreases expression
protein 22926442
D047311 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Luteolin results in increased expression of CDKN1A mRNA increases expression
mRNA 19397994
D047311 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Luteolin results in increased expression of CDKN1A protein increases expression
protein 11322924
11790449
19397994
22926442
D047311 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Luteolin results in increased expression of CDKN1B protein increases expression
protein 11322924
D047311 1031 CDKN2C
INK4C
p18
p18-INK4C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Luteolin results in decreased expression of CDKN2C mRNA decreases expression
mRNA 18331776
D047311 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Luteolin results in decreased expression of CSF2 mRNA decreases expression
mRNA 10718847
D047311 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 20403331
D047311 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 17090139
D047311 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Luteolin results in decreased activity of CYP1A1 protein decreases activity
protein 21482471
D047311 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Luteolin results in increased expression of CYP1A1 mRNA increases expression
mRNA 20403331
D047311 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Luteolin results in decreased activity of CYP1B1 protein decreases activity
protein 21482471
D047311 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] decreases reaction
/ increases chemical synthesis
protein 18191104
D047311 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] decreases reaction
/ increases chemical synthesis
protein 18191104
D047311 1577 CYP3A5
CP35
CYPIIIA5
P450PCN3
PCN3
cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] decreases reaction
/ increases chemical synthesis
protein 18191104
D047311 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of PTK2 protein] decreases phosphorylation
/ decreases reaction
protein 15135307
D047311 1950 EGF
HOMG4
URG
epidermal growth factor Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 22926442
D047311 1950 EGF
HOMG4
URG
epidermal growth factor Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15135307
D047311 1950 EGF
HOMG4
URG
epidermal growth factor Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] decreases reaction
/ increases phosphorylation
protein 22926442
D047311 1950 EGF
HOMG4
URG
epidermal growth factor Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] decreases reaction
/ increases phosphorylation
protein 15135307
D047311 1950 EGF
HOMG4
URG
epidermal growth factor Luteolin inhibits the reaction [EGF protein results in increased secretion of MMP9 protein] decreases reaction
/ increases secretion
protein 15135307
D047311 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15135307
D047311 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] decreases reaction
/ increases phosphorylation
protein 22926442
D047311 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) Luteolin results in decreased expression of EGFR mRNA decreases expression
mRNA 22926442
D047311 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) Luteolin results in decreased phosphorylation of and results in increased activity of EGFR protein decreases phosphorylation
/ increases activity
protein 15135307
D047311 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 Luteolin results in increased expression of EGR1 mRNA increases expression
mRNA 19397994
D047311 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Luteolin binds to ESR1 protein affects binding
protein 14579009
D047311 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Luteolin inhibits the reaction [Estradiol binds to ESR1 protein] affects binding
/ decreases reaction
protein 14579009
D047311 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Luteolin binds to ESR2 protein affects binding
protein 12224631
D047311 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Luteolin results in increased activity of ESR2 protein increases activity
protein 16860978
D047311 2203 FBP1
FBP
fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) Luteolin results in decreased expression of FBP1 mRNA decreases expression
mRNA 18331776
D047311 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] affects binding
/ decreases reaction
/ increases activity
protein 15322261
D047311 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Luteolin inhibits the reaction [TNF protein results in increased expression of FOS mRNA] decreases reaction
/ increases expression
mRNA 15322261
D047311 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Luteolin results in decreased activity of FOS protein decreases activity
protein 16343431
D047311 2354 FOSB
AP-1
G0S3
GOS3
GOSB
FBJ murine osteosarcoma viral oncogene homolog B Luteolin results in decreased activity of FOSB protein decreases activity
protein 16343431
D047311 4616 GADD45B
GADD45BETA
MYD118
growth arrest and DNA-damage-inducible, beta Luteolin results in increased expression of GADD45B mRNA increases expression
mRNA 18331776
D047311 4616 GADD45B
GADD45BETA
MYD118
growth arrest and DNA-damage-inducible, beta Luteolin results in increased expression of GADD45B protein increases expression
protein 18331776
D047311 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 15113938
15322261
D047311 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 15113938
15322261
D047311 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Luteolin inhibits the reaction [Glucose results in increased expression of IL1B mRNA] decreases reaction
/ increases expression
mRNA 19557821
D047311 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Luteolin inhibits the reaction [Glucose results in increased expression of IL1B protein] decreases reaction
/ increases expression
protein 19557821
D047311 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4] affects cotreatment
/ decreases reaction
/ increases expression
16601352
D047311 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 Luteolin results in decreased expression of IL4 protein decreases expression
protein 16343431
D047311 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] affects binding
/ decreases reaction
/ increases activity
protein 15322261
D047311 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Luteolin inhibits the reaction [TNF protein results in increased expression of JUN mRNA] decreases reaction
/ increases expression
mRNA 15322261
D047311 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Luteolin promotes the reaction [TNF protein results in increased phosphorylation of JUN protein] increases phosphorylation
/ increases reaction
protein 15334063
D047311 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Luteolin results in decreased phosphorylation of and results in decreased activity of JUN protein decreases activity
/ decreases phosphorylation
protein 16343431
D047311 3726 JUNB
AP-1
jun B proto-oncogene Luteolin results in decreased activity of JUNB protein decreases activity
protein 16343431
D047311 3727 JUND
AP-1
jun D proto-oncogene Luteolin results in decreased activity of JUND protein decreases activity
protein 16343431
D047311 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 19557821
D047311 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Luteolin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 15322261
D047311 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein decreases activity
/ decreases phosphorylation
protein 10718847
D047311 5602 MAPK10
JNK3
JNK3A
PRKM10
SAPK1b
p493F12
p54bSAPK
mitogen-activated protein kinase 10 (EC:2.7.11.24) Luteolin results in increased phosphorylation of MAPK10 protein increases phosphorylation
protein 21601631
D047311 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 19557821
D047311 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein decreases activity
/ decreases phosphorylation
protein 10718847
D047311 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Luteolin promotes the reaction [TNF protein results in increased phosphorylation of MAPK8 protein] increases phosphorylation
/ increases reaction
protein 15334063
D047311 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Luteolin results in decreased phosphorylation of and results in decreased activity of MAPK8 protein decreases activity
/ decreases phosphorylation
protein 10718847
D047311 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Luteolin results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 21601631
D047311 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) Luteolin results in increased phosphorylation of MAPK9 protein increases phosphorylation
protein 21601631
D047311 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Luteolin results in decreased expression of MMP1 mRNA decreases expression
mRNA 21112745
D047311 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Luteolin results in decreased expression of MMP1 protein decreases expression
protein 21112745
D047311 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Luteolin inhibits the reaction [EGF protein results in increased secretion of MMP9 protein] decreases reaction
/ increases secretion
protein 15135307
D047311 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Luteolin results in decreased secretion of MMP9 protein decreases secretion
protein 15135307
D047311 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Luteolin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 15334063
D047311 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein] decreases expression
/ decreases reaction
/ increases degradation
protein 19557821
D047311 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Luteolin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 15322261
D047311 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] affects binding
/ decreases reaction
/ increases phosphorylation
protein 15322261
D047311 4793 NFKBIB
IKBB
TRIP9
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] affects binding
/ decreases reaction
/ increases phosphorylation
protein 15322261
D047311 9572 NR1D1
EAR1
THRA1
THRAL
ear-1
hRev
nuclear receptor subfamily 1, group D, member 1 Luteolin results in decreased expression of NR1D1 mRNA decreases expression
mRNA 19397994
D047311 5347 PLK1
PLK
STPK13
polo-like kinase 1 (EC:2.7.11.21) Luteolin results in decreased expression of PLK1 protein decreases expression
protein 22926442
D047311 8000 PSCA
PRO232
prostate stem cell antigen Luteolin results in decreased expression of PSCA mRNA decreases expression
mRNA 18331776
19397994
D047311 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 19557821
D047311 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 19557821
D047311 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of PTK2 protein] decreases phosphorylation
/ decreases reaction
protein 15135307
D047311 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] decreases reaction
/ increases phosphorylation
protein 15135307
D047311 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Luteolin results in decreased phosphorylation of PTK2 protein decreases phosphorylation
protein 15135307
D047311 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Luteolin inhibits the reaction [Glucose affects the localization of RELA protein] affects localization
/ decreases reaction
protein 19557821
D047311 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Luteolin inhibits the reaction [TNF protein affects the localization of RELA protein] affects localization
/ decreases reaction
protein 15113938
D047311 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Luteolin inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 15334063
D047311 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E Luteolin inhibits the reaction [TNF protein results in increased expression of SELE mRNA] decreases reaction
/ increases expression
mRNA 15113938
D047311 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E Luteolin inhibits the reaction [TNF protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 15113938
D047311 2810 SFN
YWHAS
stratifin Luteolin results in increased expression of SFN mRNA increases expression
mRNA 18331776
D047311 2810 SFN
YWHAS
stratifin Luteolin results in increased expression of SFN protein increases expression
protein 18331776
D047311 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Luteolin affects the activity of SOD1 protein affects activity
protein 18503759
D047311 29110 TBK1
NAK
T2K
TANK-binding kinase 1 (EC:2.7.11.1) Luteolin results in decreased activity of TBK1 protein decreases activity
protein 19426678
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [Glucose results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 19557821
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [Glucose results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 19557821
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein affects the localization of RELA protein] affects localization
/ decreases reaction
protein 15113938
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] affects binding
/ decreases reaction
/ increases activity
protein 15322261
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 15322261
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 15334063
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 15334063
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 15322261
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] decreases reaction
/ increases expression
protein 15334063
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of FOS mRNA] decreases reaction
/ increases expression
protein 15322261
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
protein 15113938
15322261
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 15113938
15322261
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of JUN mRNA] decreases reaction
/ increases expression
protein 15322261
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of SELE mRNA] decreases reaction
/ increases expression
protein 15113938
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 15113938
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] decreases reaction
/ increases expression
protein 15334063
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 15113938
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 15113938
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] affects binding
/ decreases reaction
/ increases phosphorylation
protein 15322261
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein] increases activity
/ increases cleavage
/ increases reaction
protein 15334063
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin promotes the reaction [TNF protein results in increased phosphorylation of JUN protein] increases phosphorylation
/ increases reaction
protein 15334063
D047311 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Luteolin promotes the reaction [TNF protein results in increased phosphorylation of MAPK8 protein] increases phosphorylation
/ increases reaction
protein 15334063
D047311 7128 TNFAIP3
A20
OTUD7C
TNFA1P2
tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) Luteolin inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] decreases reaction
/ increases expression
protein 15334063
D047311 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 16140950
D047311 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein] increases activity
/ increases reaction
protein 16140950
D047311 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 Luteolin promotes the reaction [TNFSF10 protein results in increased ubiquitination of and results in increased degradation of and results in decreased expression of XIAP protein] decreases expression
/ increases degradation
/ increases reaction
/ increases ubiquitination
protein 16140950
D047311 9540 TP53I3
PIG3
tumor protein p53 inducible protein 3 Luteolin results in increased expression of TP53I3 mRNA increases expression
mRNA 18331776
19397994
D047311 9540 TP53I3
PIG3
tumor protein p53 inducible protein 3 Luteolin results in increased expression of TP53I3 protein increases expression
protein 18331776
19397994
D047311 8626 TP63
AIS
B(p51A)
B(p51B)
EEC3
KET
LMS
NBP
OFC8
RHS
SHFM4
TP53CP
TP53L
TP73L
p40
p51
p53CP
p63
p73H
p73L
tumor protein p63 Luteolin results in increased expression of TP63 protein increases expression
protein 18331776
19397994
D047311 7161 TP73
P73
tumor protein p73 Luteolin results in increased expression of TP73 protein increases expression
protein 18331776
19397994
D047311 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 mRNA] decreases reaction
/ increases expression
mRNA 20403331
D047311 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 mutant form affects the glucuronidation of Luteolin affects glucuronidation
mutant form 16738032
D047311 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of Luteolin increases glucuronidation
protein 16738032
D047311 10451 VAV3
vav 3 guanine nucleotide exchange factor Luteolin results in decreased expression of VAV3 mRNA decreases expression
mRNA 19397994
D047311 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 15113938
D047311 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Luteolin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 15113938
D047311 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Luteolin results in decreased expression of VEGFA mRNA decreases expression
mRNA 19005980
D047311 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Luteolin results in decreased expression of VEGFA protein decreases expression
protein 19005980
D047311 8839 WISP2
CCN5
CT58
CTGF-L
WNT1 inducible signaling pathway protein 2 Luteolin results in decreased expression of WISP2 mRNA decreases expression
mRNA 19397994
D047311 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Luteolin promotes the reaction [TNFSF10 protein results in increased ubiquitination of and results in increased degradation of and results in decreased expression of XIAP protein] decreases expression
/ increases degradation
/ increases reaction
/ increases ubiquitination
protein 16140950

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (91)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P18054
P84022
Q14191
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#230200 Galactokinase deficiency P51570
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#275355 Squamous cell carcinoma, head and neck; hnscc O14763
P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (95)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q15046 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00028 Choriocarcinoma P03956 (related)
P04637 (related)
P08253 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00070 Galactosemia P51570 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

6 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D009202 D047311 Cardiomyopathies therapeutic
9242351
D002386 D047311 Cataract therapeutic
22342831
D005483 D047311 Flushing therapeutic
18223672
D006529 D047311 Hepatomegaly therapeutic
19747501
D008103 D047311 Liver Cirrhosis therapeutic
19747501
D010051 D047311 Ovarian Neoplasms therapeutic
19005980