| Organism name | Myoporum bontioides | 
|---|---|
| Genus | Myoporum | 
| Family | Myoporaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Myoporum | 
|---|---|
| Linked NCBI taxonomy ID | 57115 | 
| Linked level | genus | 
| Family in NCBI taxonomy | Scrophulariaceae | 
|---|---|
| ID | 4149 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | asterids | 
|---|---|
| ID | 71274 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00013329   | Tricin / 5,7,4'-Trihydroxy-3',5'-dimethoxyflavone / 5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one | CHEMBL454320 | C017769 | No. 3 | No. 15 |   | ||
| C00001029   | Chrysoeriol / Luteolin 3'-methyl ether | CHEMBL214321 | C007054 | 20 / 24 / 20 | 8 / 0 | No. 3 | No. 15 |   | 
| C00002783   | Kusaginin / Acteoside / Verbascoside | CHEMBL231853 CHEMBL444478 CHEMBL1364101 | C058956 | 12 / 1 / 1 | 34 / 3 | No. 33 |   | |
| C00034095   | Oxoverbascoside | No. 33 |   | |||||
| C00030516   | Isoacteoside / Isoverbascoside | CHEMBL504873 | C064683 | 6 / 5 / 4 | No. 33 |   | ||
| C00033723   | Cimidahurine | No. 45 | No. 72 |   | ||||
| C00034066   | Myobontioside A / (-)-Myobontioside A | No. 64 | No. 36 |   | ||||
| C00000674   | Luteolin | CHEMBL151 | D047311 | 99 / 91 / 95 | 76 / 6 | No. 71 | No. 15 |   | 
| C00030098   | Verbasoside / (-)-Verbasoside / Decaffeoylverbascoside / (-)-Decaffeoylverbascoside | CHEMBL1779146 | No. 128 | No. 72 |   | |||
| C00034067   | Myobontioside B / (-)-Myobontioside B | No. 287 | No. 36 |   | ||||
| C00034068   | Myopochlorin / (+)-Myopochlorin | No. 787 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00000674 C00001029 C00002783 | 0 / 0 | 
| P39748 | Flap endonuclease 1 | Enzyme | C00000674 C00001029 C00002783 | 0 / 0 | 
| P08253 | 72 kDa type IV collagenase | M10A | C00000674 C00030516 | 1 / 3 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000674 C00002783 | 0 / 0 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000674 C00002783 | 0 / 0 | 
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000674 C00002783 | 0 / 0 | 
| Q99700 | Ataxin-2 | Unclassified protein | C00000674 C00002783 | 1 / 1 | 
| P08254 | Stromelysin-1 | M10A | C00000674 C00030516 | 1 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000674 C00001029 | 4 / 3 | 
| P06746 | DNA polymerase beta | Enzyme | C00000674 C00001029 | 0 / 0 | 
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000674 C00002783 | 0 / 0 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000674 C00002783 | 0 / 0 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000674 C00001029 | 0 / 0 | 
| P39900 | Macrophage metalloelastase | M10A | C00000674 C00030516 | 0 / 0 | 
| O00255 | Menin | Unclassified protein | C00000674 C00001029 | 2 / 5 | 
| P14780 | Matrix metalloproteinase-9 | M10A | C00000674 C00030516 | 2 / 2 | 
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000674 C00001029 | 0 / 0 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000674 C00001029 | 0 / 0 | 
| P45452 | Collagenase 3 | M10A | C00000674 C00030516 | 1 / 1 | 
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00000674 C00001029 | 4 / 4 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000674 C00001029 | 1 / 2 | 
| P03956 | Interstitial collagenase | M10A | C00000674 C00030516 | 0 / 1 | 
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000674 C00001029 | 4 / 2 | 
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00000674 C00001029 | 0 / 0 | 
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000674 C00001029 | 2 / 0 | 
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000674 C00002783 | 0 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000674 C00001029 | 0 / 0 | 
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00000674 C00001029 | 1 / 0 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000674 | 1 / 0 | 
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00000674 | 0 / 0 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000674 | 0 / 1 | 
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | C00000674 | 0 / 0 | 
| Q15078 | Cyclin-dependent kinase 5 activator 1 | REG serine/threonine protein kinase family | C00000674 | 0 / 0 | 
| P54132 | Bloom syndrome protein | Enzyme | C00000674 | 1 / 2 | 
| P51570 | Galactokinase | Enzyme | C00000674 | 1 / 1 | 
| Q9HC97 | G-protein coupled receptor 35 | Kynurenic acid receptor | C00000674 | 0 / 0 | 
| P08183 | Multidrug resistance protein 1 | drug | C00000674 | 1 / 0 | 
| P11387 | DNA topoisomerase 1 | Isomerase | C00000674 | 0 / 0 | 
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000674 | 0 / 0 | 
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000674 | 0 / 0 | 
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000674 | 0 / 0 | 
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00000674 | 0 / 0 | 
| P49327 | Fatty acid synthase | Transferase | C00000674 | 0 / 0 | 
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00000674 | 1 / 1 | 
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000674 | 0 / 0 | 
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00000674 | 0 / 0 | 
| Q00534 | Cyclin-dependent kinase 6 | CMGC serine/threonine protein kinase family | C00000674 | 1 / 0 | 
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000674 | 1 / 1 | 
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000674 | 3 / 1 | 
| P09874 | Poly [ADP-ribose] polymerase 1 | Enzyme | C00000674 | 0 / 0 | 
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000674 | 1 / 1 | 
| Q9Y253 | DNA polymerase eta | Enzyme | C00000674 | 1 / 1 | 
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002783 | 0 / 0 | 
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000674 | 3 / 2 | 
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002783 | 0 / 0 | 
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00000674 | 0 / 0 | 
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000674 | 0 / 0 | 
| P04150 | Glucocorticoid receptor | NR3C1 | C00000674 | 0 / 1 | 
| P14679 | Tyrosinase | Oxidoreductase | C00000674 | 4 / 2 | 
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001029 | 5 / 3 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00000674 | 11 / 10 | 
| P06276 | Cholinesterase | Hydrolase | C00000674 | 0 / 0 | 
| P06280 | Alpha-galactosidase A | Enzyme | C00000674 | 1 / 1 | 
| P04745 | Alpha-amylase 1 | Enzyme | C00000674 | 0 / 0 | 
| O95271 | Tankyrase-1 | Enzyme | C00000674 | 0 / 0 | 
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00000674 | 2 / 0 | 
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000674 | 0 / 1 | 
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001029 | 0 / 0 | 
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000674 | 3 / 3 | 
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00000674 | 2 / 0 | 
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001029 | 1 / 1 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000674 | 2 / 2 | 
| P17252 | Protein kinase C alpha type | Alpha | C00002783 | 0 / 0 | 
| Q9H2K2 | Tankyrase-2 | Enzyme | C00000674 | 0 / 0 | 
| O14763 | Tumor necrosis factor receptor superfamily member 10B | Unclassified protein | C00000674 | 1 / 0 | 
| P03372 | Estrogen receptor | NR3A1 | C00000674 | 1 / 1 | 
| P22303 | Acetylcholinesterase | Hydrolase | C00000674 | 1 / 0 | 
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000674 | 0 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000674 | 1 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000674 | 0 / 1 | 
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000674 | 1 / 1 | 
| Q15046 | Lysine--tRNA ligase | Enzyme | C00000674 | 2 / 1 | 
| P04062 | Glucosylceramidase | Enzyme | C00000674 | 6 / 4 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000674 | 0 / 0 | 
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000674 | 0 / 3 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000674 | 0 / 0 | 
| P10275 | Androgen receptor | NR3C4 | C00000674 | 3 / 4 | 
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001029 | 0 / 0 | 
| P06239 | Tyrosine-protein kinase Lck | Src | C00000674 | 0 / 1 | 
| Q04760 | Lactoylglutathione lyase | Enzyme | C00000674 | 0 / 0 | 
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00000674 | 0 / 0 | 
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000674 | 4 / 1 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000674 | 0 / 0 | 
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000674 | 0 / 0 | 
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00000674 | 0 / 0 | 
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000674 | 1 / 1 | 
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000674 | 7 / 37 | 
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000674 | 0 / 1 | 
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000674 | 1 / 4 | 
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | C00000674 | 0 / 0 | 
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | C00000674 | 0 / 0 | 
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00000674 | 0 / 0 | 
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | C00000674 | 0 / 0 | 
| P49840 | Glycogen synthase kinase-3 alpha | Gsk | C00000674 | 0 / 0 | 
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00000674 | 0 / 0 | 
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00001029 | 0 / 0 | 
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00000674 | 2 / 1 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor | C00000674
                          C00001029
                          C00002783 | 
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | C00000674
                          C00001029
                          C00002783 | 
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | C00000674
                          C00002783 | 
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 | C00000674
                          C00002783 | 
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | C00000674
                          C00001029 | 
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor | C00000674
                          C00002783 | 
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A | C00000674
                          C00002783 | 
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | C00000674
                          C00001029 | 
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) | C00000674
                          C00002783 | 
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) | C00000674
                          C00002783 | 
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 | C00000674
                          C00002783 | 
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) | C00000674
                          C00002783 | 
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | C00000674
                          C00002783 | 
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | C00000674
                          C00002783 | 
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) | C00000674
                          C00002783 | 
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) | C00000674 | 
| 1021 | CDK6, PLSTIRE | cyclin-dependent kinase 6 (EC:2.7.11.22) | C00002783 | 
| 898 | CCNE1, CCNE | cyclin E1 | C00002783 | 
| 896 | CCND3 | cyclin D3 | C00002783 | 
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 | C00002783 | 
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 | C00002783 | 
| 894 | CCND2, KIAK0002 | cyclin D2 | C00002783 | 
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 | C00002783 | 
| 3458 | IFNG, IFG, IFI | interferon, gamma | C00002783 | 
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) | C00002783 | 
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 | C00002783 | 
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | C00002783 | 
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 | C00002783 | 
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator | C00002783 | 
| 27035 | NOX1, GP91-2, MOX1, NOH-1, NOH1 | NADPH oxidase 1 | C00002783 | 
| 4835 | NQO2, DHQV, DIA6, NMOR2, QR2 | NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) | C00001029 | 
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 | C00002783 | 
| 4544 | MTNR1B, FGQTL2, MEL-1B-R, MT2 | melatonin receptor 1B | C00001029 | 
| 4087 | SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 | SMAD family member 2 | C00002783 | 
| 4088 | SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 | SMAD family member 3 | C00002783 | 
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) | C00002783 | 
| 7039 | TGFA, TFGA | transforming growth factor, alpha | C00002783 | 
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 | C00002783 | 
| 4543 | MTNR1A, MEL-1A-R, MT1 | melatonin receptor 1A | C00001029 | 
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | C00001029 | 
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 | C00000674 | 
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor | C00000674 | 
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | C00000674 | 
| 581 | BAX, BCL2L4 | BCL2-associated X protein | C00000674 | 
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 | C00000674 | 
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 | C00000674 | 
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 | C00000674 | 
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | C00000674 | 
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | C00000674 | 
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | C00000674 | 
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | C00000674 | 
| 847 | CAT | catalase (EC:1.11.1.6) | C00000674 | 
| 890 | CCNA2, CCN1, CCNA | cyclin A2 | C00000674 | 
| 891 | CCNB1, CCNB | cyclin B1 | C00000674 | 
| 958 | CD40, Bp50, CDW40, TNFRSF5, p50 | CD40 molecule, TNF receptor superfamily member 5 | C00000674 | 
| 972 | CD74, DHLAG, HLADG, II, Ia-GAMMA | CD74 molecule, major histocompatibility complex, class II invariant chain | C00000674 | 
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) | C00000674 | 
| 1031 | CDKN2C, INK4C, p18, p18-INK4C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | C00000674 | 
| 1437 | CSF2, GMCSF | colony stimulating factor 2 (granulocyte-macrophage) | C00000674 | 
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | C00000674 | 
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) | C00000674 | 
| 1950 | EGF, HOMG4, URG | epidermal growth factor | C00000674 | 
| 1958 | EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 | early growth response 1 | C00000674 | 
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 | C00000674 | 
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) | C00000674 | 
| 2203 | FBP1, FBP | fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) | C00000674 | 
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog | C00000674 | 
| 2354 | FOSB, AP-1, G0S3, GOS3, GOSB | FBJ murine osteosarcoma viral oncogene homolog B | C00000674 | 
| 4616 | GADD45B, GADD45BETA, MYD118 | growth arrest and DNA-damage-inducible, beta | C00000674 | 
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta | C00000674 | 
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 | C00000674 | 
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene | C00000674 | 
| 3726 | JUNB, AP-1 | jun B proto-oncogene | C00000674 | 
| 3727 | JUND, AP-1 | jun D proto-oncogene | C00000674 | 
| 5602 | MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK | mitogen-activated protein kinase 10 (EC:2.7.11.24) | C00000674 | 
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) | C00002783 | 
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) | C00000674 | 
| 4312 | MMP1, CLG, CLGN | matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) | C00000674 | 
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | C00000674 | 
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | C00000674 | 
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | C00000674 | 
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | C00000674 | 
| 9572 | NR1D1, EAR1, THRA1, THRAL, ear-1, hRev | nuclear receptor subfamily 1, group D, member 1 | C00000674 | 
| 5347 | PLK1, PLK, STPK13 | polo-like kinase 1 (EC:2.7.11.21) | C00000674 | 
| 8000 | PSCA, PRO232 | prostate stem cell antigen | C00000674 | 
| 5747 | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK | protein tyrosine kinase 2 (EC:2.7.10.2) | C00000674 | 
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E | C00000674 | 
| 2810 | SFN, YWHAS | stratifin | C00000674 | 
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) | C00000674 | 
| 29110 | TBK1, NAK, T2K | TANK-binding kinase 1 (EC:2.7.11.1) | C00000674 | 
| 7128 | TNFAIP3, A20, OTUD7C, TNFA1P2 | tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) | C00000674 | 
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 | C00000674 | 
| 9540 | TP53I3, PIG3 | tumor protein p53 inducible protein 3 | C00000674 | 
| 8626 | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L | tumor protein p63 | C00000674 | 
| 7161 | TP73, P73 | tumor protein p73 | C00000674 | 
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | C00000674 | 
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) | C00000674 | 
| 10451 | VAV3 | vav 3 guanine nucleotide exchange factor | C00000674 | 
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A | C00000674 | 
| 8839 | WISP2, CCN5, CT58, CTGF-L | WNT1 inducible signaling pathway protein 2 | C00000674 | 
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis | C00000674 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency | Q99714 | 
| #202300 | Adrenocortical carcinoma, hereditary; adcc | P04637 | 
| #103470 | Albinism, ocular, with sensorineural deafness | P14679 | 
| #203100 | Albinism, oculocutaneous, type ia; oca1a | P14679 | 
| #606952 | Albinism, oculocutaneous, type ib; oca1b | P14679 | 
| #300068 | Androgen insensitivity syndrome; ais | P10275 | 
| #312300 | Androgen insensitivity, partial; pais | P10275 | 
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 | P04637 | 
| #614490 | Blood group, junior system; jr | Q9UNQ0 | 
| #210900 | Bloom syndrome; blm | P54132 | 
| %606641 | Body mass index; bmi | P37231 | 
| #114480 | Breast cancer | P38398 | 
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 | P38398 | 
| #300615 | Brunner syndrome | P21397 | 
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #609338 | Carotid intimal medial thickness 1 | P37231 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #613641 | Charcot-marie-tooth disease, recessive intermediate b; cmtrib | Q15046 | 
| #114500 | Colorectal cancer; crc | P18054 P84022 Q14191 | 
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 | P08254 | 
| #613916 | Deafness, autosomal recessive 89; dfnb89 | Q15046 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #237500 | Dubin-johnson syndrome; djs | Q92887 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #133239 | Esophageal cancer | P04637 P18054 | 
| #615363 | Estrogen resistance; estrr | P03372 | 
| #301500 | Fabry disease | P06280 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #230200 | Galactokinase deficiency | P51570 | 
| #608013 | Gaucher disease, perinatal lethal | P04062 | 
| #230800 | Gaucher disease, type i | P04062 | 
| #230900 | Gaucher disease, type ii | P04062 | 
| #231000 | Gaucher disease, type iii | P04062 | 
| #231005 | Gaucher disease, type iiic | P04062 | 
| #137750 | Glaucoma 1, open angle, a; glc1a | Q16678 | 
| #231300 | Glaucoma 3, primary congenital, a; glc3a | Q16678 | 
| #137760 | Glaucoma, primary open angle; poag | Q16678 | 
| #137800 | Glioma susceptibility 1; glm1 | P37231 | 
| #232300 | Glycogen storage disease ii | P10253 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #145000 | Hyperparathyroidism 1; hrpt1 | O00255 | 
| #603373 | Hyperthyroidism, familial gestational | P16473 | 
| #609152 | Hyperthyroidism, nonautoimmune | P16473 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 | P16473 | 
| #612244 | Inflammatory bowel disease 13; ibd13 | P08183 | 
| #603932 | Intervertebral disc disease; idd | P14780 | 
| #601626 | Leukemia, acute myeloid; aml | P36888 | 
| #151623 | Li-fraumeni syndrome 1; lfs1 | P04637 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 | P37231 | 
| #613795 | Loeys-dietz syndrome, type 3; lds3 | P84022 | 
| #211980 | Lung cancer | P04637 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #300705 | Mental retardation, x-linked 17; mrx17 | Q99714 | 
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 | Q99714 | 
| #613073 | Metaphyseal anadysplasia 2; mandp2 | P14780 | 
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona | P08253 | 
| #131100 | Multiple endocrine neoplasia, type i; men1 | O00255 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #160900 | Myotonic dystrophy 1; dm1 | Q9NR56 | 
| #601665 | Obesity | P37231 | 
| #167000 | Ovarian cancer | P38398 | 
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 | P38398 | 
| #260500 | Papilloma of choroid plexus; cpp | P04637 | 
| #168600 | Parkinson disease, late-onset; pd | P04062 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #604229 | Peters anomaly | Q16678 | 
| #172700 | Pick disease of brain | P10636 | 
| #601399 | Platelet disorder, familial, with associated myeloid malignancy | Q01196 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 | P14679 | 
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 | P10275 | 
| #253300 | Spinal muscular atrophy, type i; sma1 | Q16637 | 
| #253550 | Spinal muscular atrophy, type ii; sma2 | Q16637 | 
| #253400 | Spinal muscular atrophy, type iii; sma3 | Q16637 | 
| #271150 | Spinal muscular atrophy, type iv; sma4 | Q16637 | 
| #183090 | Spinocerebellar ataxia 2; sca2 | Q99700 | 
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 | Q9NUW8 | 
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type | P45452 | 
| #275355 | Squamous cell carcinoma, head and neck; hnscc | O14763 P04637 | 
| %612223 | Stature quantitative trait locus 11; stqtl11 | Q00534 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth | P10828 | 
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth | P10828 | 
| #145650 | Thyroid hormone resistance, selective pituitary; prth | P10828 | 
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 | Q9UNQ0 | 
| #277700 | Werner syndrome; wrn | Q14191 | 
| #278300 | Xanthinuria, type i | P47989 | 
| #278750 | Xeroderma pigmentosum, variant type; xpv | Q9Y253 | 
| #112100 | Yt blood group antigen | P22303 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | O00255
                            (related) P04637 (related) | 
| H00034 | Carcinoid | O00255
                            (related) | 
| H00045 | Malignant islet cell carcinoma | O00255
                            (related) | 
| H00246 | Primary hyperparathyroidism | O00255
                            (related) | 
| H01102 | Pituitary adenomas | O00255
                            (related) | 
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) Q15046 (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) P37231 (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00026 | Endometrial Cancer | P03372
                            (marker) P04637 (related) | 
| H00028 | Choriocarcinoma | P03956
                            (related) P04637 (related) P08253 (related) | 
| H00066 | Lewy body dementia (LBD) | P04062
                            (related) | 
| H00126 | Gaucher disease | P04062
                            (related) | 
| H00426 | Defects in the degradation of ganglioside | P04062
                            (related) | 
| H00810 | Progressive myoclonic epilepsy (PME) | P04062
                            (related) | 
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) | P04150
                            (related) | 
| H00004 | Chronic myeloid leukemia (CML) | P04637
                            (related) Q01196 (related) | 
| H00005 | Chronic lymphocytic leukemia (CLL) | P04637
                            (related) P28907 (marker) | 
| H00006 | Hairy-cell leukemia | P04637
                            (related) | 
| H00008 | Burkitt lymphoma | P04637
                            (related) | 
| H00009 | Adult T-cell leukemia | P04637
                            (related) | 
| H00010 | Multiple myeloma | P04637
                            (related) | 
| H00013 | Small cell lung cancer | P04637
                            (related) | 
| H00014 | Non-small cell lung cancer | P04637
                            (related) | 
| H00015 | Malignant pleural mesothelioma | P04637
                            (related) | 
| H00016 | Oral cancer | P04637
                            (related) P04637 (marker) | 
| H00017 | Esophageal cancer | P04637
                            (related) P04637 (marker) P35354 (related) | 
| H00018 | Gastric cancer | P04637
                            (related) | 
| H00019 | Pancreatic cancer | P04637
                            (related) P04637 (marker) | 
| H00020 | Colorectal cancer | P04637
                            (related) P04637 (marker) | 
| H00022 | Bladder cancer | P04637
                            (related) | 
| H00025 | Penile cancer | P04637
                            (related) P04637 (marker) P08253 (related) P14780 (related) P35354 (related) | 
| H00027 | Ovarian cancer | P04637
                            (related) P38398 (related) | 
| H00029 | Vulvar cancer | P04637
                            (related) | 
| H00031 | Breast cancer | P04637
                            (related) P38398 (related) | 
| H00032 | Thyroid cancer | P04637
                            (related) P37231 (related) | 
| H00036 | Osteosarcoma | P04637
                            (related) P08684 (marker) | 
| H00038 | Malignant melanoma | P04637
                            (related) P14679 (marker) | 
| H00039 | Basal cell carcinoma | P04637
                            (related) | 
| H00040 | Squamous cell carcinoma | P04637
                            (related) | 
| H00041 | Kaposi's sarcoma | P04637
                            (related) | 
| H00042 | Glioma | P04637
                            (related) P04637 (marker) | 
| H00044 | Cancer of the anal canal | P04637
                            (related) | 
| H00046 | Cholangiocarcinoma | P04637
                            (related) P35354 (related) | 
| H00047 | Gallbladder cancer | P04637
                            (related) | 
| H00048 | Hepatocellular carcinoma | P04637
                            (related) | 
| H00055 | Laryngeal cancer | P04637
                            (related) P04637 (marker) | 
| H00881 | Li-Fraumeni syndrome | P04637
                            (related) | 
| H01007 | Choroid plexus papilloma | P04637
                            (related) | 
| H00021 | Renal cell carcinoma | P04637
                            (marker) | 
| H00093 | Combined immunodeficiencies (CIDs) | P06239
                            (related) | 
| H00125 | Fabry disease | P06280
                            (related) | 
| H00472 | Torg-Winchester syndrome | P08253
                            (related) | 
| H00069 | Glycogen storage diseases (GSD) | P10253
                            (related) | 
| H00024 | Prostate cancer | P10275
                            (related) | 
| H00062 | Spinal and bulbar muscular atrophy (SBMA) | P10275
                            (related) | 
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) | P10275
                            (related) | 
| H00609 | 46,XY disorders of sex development (Other) | P10275
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H00249 | Thyroid hormone resistance syndrome | P10828
                            (related) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H00168 | Oculocutaneous albinism (OCA) | P14679
                            (related) | 
| H00479 | Metaphyseal dysplasias | P14780
                            (related) P45452 (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | P16473
                            (related) | 
| H01269 | Congenital hyperthyroidism | P16473
                            (related) | 
| H00548 | Brunner syndrome | P21397
                            (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00003 | Acute myeloid leukemia (AML) | P36888
                            (related) Q01196 (related) Q01196 (marker) Q13951 (marker) | 
| H00409 | Type II diabetes mellitus | P37231
                            (related) | 
| H00192 | Xanthinuria | P47989
                            (related) | 
| H00070 | Galactosemia | P51570
                            (related) | 
| H00094 | DNA repair defects | P54132
                            (related) | 
| H00296 | Defects in RecQ helicases | P54132
                            (related) Q14191 (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q01196
                            (related) Q01196 (marker) Q03164 (related) Q03164 (marker) | 
| H00978 | Thrombocytopenia (THC) | Q01196
                            (related) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00455 | Spinal muscular atrophy (SMA) | Q16637
                            (related) | 
| H00612 | Primary open angle glaucoma | Q16678
                            (related) | 
| H01075 | Peters anomaly | Q16678
                            (related) | 
| H01159 | Anterior segment dysgenesis (ASD) | Q16678
                            (related) | 
| H01203 | Primary congenital glaucoma (PCG) | Q16678
                            (related) | 
| H00208 | Hyperbilirubinemia | Q92887
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q99700
                            (related) Q9NUW8 (related) | 
| H00480 | Non-syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00658 | Syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency | Q99714
                            (related) | 
| H00403 | Disorders of nucleotide excision repair | Q9Y253
                            (related) | 
| MESH or OMIM | name | KNApSAcK metabolite | 
|---|---|---|
| D007249 | Inflammation | C00002783 | 
| D007938 | Leukemia | C00002783 | 
| D014947 | Wounds and Injuries | C00002783 | 
| D009202 | Cardiomyopathies | C00000674 | 
| D002386 | Cataract | C00000674 | 
| D005483 | Flushing | C00000674 | 
| D006529 | Hepatomegaly | C00000674 | 
| D008103 | Liver Cirrhosis | C00000674 | 
| D010051 | Ovarian Neoplasms | C00000674 |