PCIDB

KNApSAcK Metabolite C00002783

Metabolite

KNApSAcK Entry

id C00002783
Name Kusaginin / Acteoside / Verbascoside
CAS RN 61276-17-3
Standard InChI InChI=1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13?,20?,22-,23-,24?,25?,26+,27+,28+,29-/m0/s1
Standard InChI (Main Layer) InChI=1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 33

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL231853 CHEMBL444478 CHEMBL1364101

KEGG

By LinkDB C10501

CTD

By CAS RN C058956

Species

Summary

Plant class

class name count
asterids 96
rosids 1
Magnoliophyta 1

Family (Top 10)

family name count
Plantaginaceae 33
Oleaceae 25
Lamiaceae 9
Acanthaceae 7
Bignoniaceae 7
Scrophulariaceae 6
Verbenaceae 5
Gesneriaceae 3
Malvaceae 1
Magnoliaceae 1

List (100)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Abeliophyllum distichum Nakai 126358 Oleaceae asterids Viridiplantae
Acanthus ebracteatus 241842 Acanthaceae asterids Viridiplantae
Acanthus ilicifolius 328098 Acanthaceae asterids Viridiplantae
Aeschynanthus bracteatus 175969 Gesneriaceae asterids Viridiplantae
Asystasia intrusa 141291 Acanthaceae asterids Viridiplantae
Barleria lupulina 101743 Acanthaceae asterids Viridiplantae
Barleria prionitis 4189 Acanthaceae asterids Viridiplantae
Barleria strigosa 4188 Acanthaceae asterids Viridiplantae
Barnettia kerrii 24079 Bignoniaceae asterids Viridiplantae
Buddleja globosa 168495 Scrophulariaceae asterids Viridiplantae
Buddleja officinalis 714454 Scrophulariaceae asterids Viridiplantae
Camptoloma lyperiiflorum (Vatke) Hillard 133312 Plantaginaceae asterids Viridiplantae
Chelone obliqua 46064 Plantaginaceae asterids Viridiplantae
Clerodendrum inerme 49994 Lamiaceae asterids Viridiplantae
Conandron ramoidioides 121478 Gesneriaceae asterids Viridiplantae
Dolichandrone serrulata 241843 Bignoniaceae asterids Viridiplantae
Ellisiophyllum pinnatum (Wall.ex.Benth.) 263962 Plantaginaceae asterids Viridiplantae
Fernandoa adenophylla 260310 Bignoniaceae asterids Viridiplantae
Firmiana platanifolia 190243 Malvaceae rosids Viridiplantae
Fontanesia fortunei Carr. 126408 Oleaceae asterids Viridiplantae
Fontanesia phillyreoides Labill. 126410 Oleaceae asterids Viridiplantae
Forsythia japonica Makino 205690 Oleaceae asterids Viridiplantae
Forsythia koreana (Rehd.) Nakai 55182 Oleaceae asterids Viridiplantae
Forsythia spp. 55182 Oleaceae asterids Viridiplantae
Forsythia viridissima Lindl. 205691 Oleaceae asterids Viridiplantae
Fraxinus americana 38872 Oleaceae asterids Viridiplantae
Fraxinus americana L. 38872 Oleaceae asterids Viridiplantae
Fraxinus excelsior L. 38873 Oleaceae asterids Viridiplantae
Fraxinus griffithii C.B.Clarke 880137 Oleaceae asterids Viridiplantae
Fraxinus malacophylla Hemsl. 880141 Oleaceae asterids Viridiplantae
Fraxinus ornus L. 38874 Oleaceae asterids Viridiplantae
Fraxinus oxycarba 38871 Oleaceae asterids Viridiplantae
Fraxinus oxycarpa Willd. 38871 Oleaceae asterids Viridiplantae
Fraxinus uhdei (Wenzig) Lingelsh. 38871 Oleaceae asterids Viridiplantae
Globularia davisiana 69062 Plantaginaceae asterids Viridiplantae
Globularia trichosantha 285841 Plantaginaceae asterids Viridiplantae
Jasminum amplexicaule Buch.-Ham. 4147 Oleaceae asterids Viridiplantae
Jasminum mesnyi Hance 105898 Oleaceae asterids Viridiplantae
Jasminum nudiflorum 126431 Oleaceae asterids Viridiplantae
Jasminum polyanthum Franch. 85216 Oleaceae asterids Viridiplantae
Kigelia africana 70070 Bignoniaceae asterids Viridiplantae
Lamium garganicum 53162 Lamiaceae asterids Viridiplantae
Lamium purpureum L. 53164 Lamiaceae asterids Viridiplantae
Lantana sp. 87005 Verbenaceae asterids Viridiplantae
Leucosceptrum japonicum 694320 Lamiaceae asterids Viridiplantae
Ligustrum obtusifolium Sieb.et Zucc. 13596 Oleaceae asterids Viridiplantae
Lippia alba 320345 Verbenaceae asterids Viridiplantae
Lippia dulcis TREV. 320344 Verbenaceae asterids Viridiplantae
Lysionotus pauciflorus 48809 Gesneriaceae asterids Viridiplantae
Magnolia officinalis 85864 Magnoliaceae Magnoliophyta Viridiplantae
Markhamia lutea 211921 Bignoniaceae asterids Viridiplantae
Markhamia stipulata 211921 Bignoniaceae asterids Viridiplantae
Myoporum bontioides 57115 Scrophulariaceae asterids Viridiplantae
Newbouldia laevis 211924 Bignoniaceae asterids Viridiplantae
Orobanche rapum 36747 Orobanchaceae asterids Viridiplantae
Osmanthus fragrans (Thunb.) Lour. 93977 Oleaceae asterids Viridiplantae
Osmanthus heterophyllus (G.Don) P.S.Green 126555 Oleaceae asterids Viridiplantae
Pentemon gentianoides HBK
Phlomis caucasica 316257 Lamiaceae asterids Viridiplantae
Phlomis grandiflora var. grandiflora 316257 Lamiaceae asterids Viridiplantae
Phlomis lanceolata 997724 Lamiaceae asterids Viridiplantae
Pithecotenium crucigerum (L.) A.H Gentry
Plantago afra 101998 Plantaginaceae asterids Viridiplantae
Plantago alpina 197791 Plantaginaceae asterids Viridiplantae
Plantago altissima 26867 Plantaginaceae asterids Viridiplantae
Plantago arborescens 197793 Plantaginaceae asterids Viridiplantae
Plantago arenaria 197794 Plantaginaceae asterids Viridiplantae
Plantago asiatica 197796 Plantaginaceae asterids Viridiplantae
Plantago australis 101995 Plantaginaceae asterids Viridiplantae
Plantago bellardi 26867 Plantaginaceae asterids Viridiplantae
Plantago cretica 197801 Plantaginaceae asterids Viridiplantae
Plantago hookeriana 197805 Plantaginaceae asterids Viridiplantae
Plantago lagopus 185001 Plantaginaceae asterids Viridiplantae
Plantago lanceolata 39414 Plantaginaceae asterids Viridiplantae
Plantago lundborgii 197807 Plantaginaceae asterids Viridiplantae
Plantago major 29818 Plantaginaceae asterids Viridiplantae
Plantago myosuros 197812 Plantaginaceae asterids Viridiplantae
Plantago nivalis 197813 Plantaginaceae asterids Viridiplantae
Plantago ovata 185002 Plantaginaceae asterids Viridiplantae
Plantago patagonica 197815 Plantaginaceae asterids Viridiplantae
Plantago raoulii 197816 Plantaginaceae asterids Viridiplantae
Plantago sempervirens 197819 Plantaginaceae asterids Viridiplantae
Plantago stauntonii 197823 Plantaginaceae asterids Viridiplantae
Plantago subspathulata 197825 Plantaginaceae asterids Viridiplantae
Plantago subulata 197826 Plantaginaceae asterids Viridiplantae
Plantago uniflora 197831 Plantaginaceae asterids Viridiplantae
Plantago webbii 197833 Plantaginaceae asterids Viridiplantae
Prostanthera melissifolia 1290920 Lamiaceae asterids Viridiplantae
Scrophularia ningpoensis 291326 Scrophulariaceae asterids Viridiplantae
Scrophularia nodosa L. 90363 Scrophulariaceae asterids Viridiplantae
Sibthorpia africana L. 165319 Plantaginaceae asterids Viridiplantae
Sibthorpia europea L. 165319 Plantaginaceae asterids Viridiplantae
Stachys lanata 53171 Lamiaceae asterids Viridiplantae
Strobilanthes cusia BREMEK 24051 Acanthaceae asterids Viridiplantae
Syringa reticulata (Blume) Hara 24208 Oleaceae asterids Viridiplantae
Syringa vulgaris L. 24208 Oleaceae asterids Viridiplantae
Verbascum sinuatum 1042526 Scrophulariaceae asterids Viridiplantae
Verbena littoralis 22002 Verbenaceae asterids Viridiplantae
Verbenoxylum reitzii 21910 Verbenaceae asterids Viridiplantae
Veronica austriaca L. 165327 Plantaginaceae asterids Viridiplantae

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1364101 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL444478 CHEMBL2114784 (1)
1 / 1
P17252 Protein kinase C alpha type Alpha CHEMBL231853 CHEMBL997396 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL444478 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL444478 CHEMBL2114843 (1)
0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL444478 CHEMBL1364101 CHEMBL1614280 (2)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL444478 CHEMBL1794401 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL444478 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL444478 CHEMBL1737991 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL444478 CHEMBL1794536 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1364101 CHEMBL1738442 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL444478 CHEMBL2114738 (1)
0 / 0

CTD interaction (78)

compound gene gene name gene description interaction interaction type form reference
pmid
C058956 196 AHR
bHLHe76
aryl hydrocarbon receptor acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein] increases localization
/ increases reaction
protein 21756928
C058956 196 AHR
bHLHe76
aryl hydrocarbon receptor acteoside results in decreased localization of AHR protein decreases localization
protein 21756928
C058956 405 ARNT
HIF-1-beta
HIF-1beta
HIF1-beta
HIF1B
HIF1BETA
TANGO
bHLHe2
aryl hydrocarbon receptor nuclear translocator acteoside results in increased localization of ARNT protein increases localization
protein 21756928
C058956 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
mRNA 21756928
C058956 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 acteoside results in decreased expression of CCL2 mRNA decreases expression
mRNA 21756928
21967610
C058956 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 acteoside results in decreased secretion of CCL2 protein decreases secretion
protein 21967610
C058956 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 acteoside results in decreased expression of CCND1 protein decreases expression
protein 17634406
C058956 894 CCND2
KIAK0002
cyclin D2 acteoside results in decreased expression of CCND2 protein decreases expression
protein 17634406
C058956 896 CCND3
cyclin D3 acteoside results in decreased expression of CCND3 protein decreases expression
protein 17634406
C058956 898 CCNE1
CCNE
cyclin E1 acteoside results in decreased expression of CCNE1 protein decreases expression
protein 17634406
C058956 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) acteoside results in decreased expression of and results in decreased activity of CDK2 protein decreases activity
/ decreases expression
protein 17634406
C058956 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein] affects binding
/ increases reaction
protein 17634406
C058956 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein] affects binding
/ increases reaction
protein 17634406
C058956 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) acteoside results in decreased activity of CDK4 protein decreases activity
protein 17634406
C058956 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein] affects binding
/ increases reaction
protein 17634406
C058956 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein] affects binding
/ increases reaction
protein 17634406
C058956 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) acteoside results in decreased expression of and results in decreased activity of CDK6 protein decreases activity
/ decreases expression
protein 17634406
C058956 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein] affects binding
/ increases reaction
protein 17634406
C058956 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein] affects binding
/ increases reaction
protein 17634406
C058956 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) acteoside results in increased expression of CDKN1A mRNA increases expression
mRNA 17634406
C058956 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) acteoside results in increased expression of CDKN1A protein increases expression
protein 17634406
C058956 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein] affects binding
/ increases reaction
protein 17634406
C058956 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein] affects binding
/ increases reaction
protein 17634406
C058956 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) acteoside results in increased expression of CDKN1B mRNA increases expression
mRNA 17634406
C058956 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) acteoside results in increased expression of CDKN1B protein increases expression
protein 17634406
C058956 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein] decreases reaction
/ increases secretion
protein 21967610
C058956 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
C058956 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein] decreases secretion
/ increases reaction
protein 21967610
C058956 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 acteoside results in decreased expression of CXCL10 mRNA decreases expression
mRNA 21756928
21967610
C058956 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 acteoside results in decreased secretion of CXCL10 protein decreases secretion
protein 21756928
21967610
C058956 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) acteoside results in increased expression of CYP1A1 mRNA increases expression
mRNA 21756928
C058956 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] affects binding
/ decreases phosphorylation
/ increases reaction
protein 17634406
C058956 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] affects localization
/ increases reaction
protein 21967610
C058956 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form] affects localization
/ increases reaction
protein 21967610
C058956 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) acteoside results in decreased phosphorylation of EGFR protein decreases phosphorylation
protein 21756928
21967610
C058956 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 acteoside results in decreased expression of ICAM1 mRNA decreases expression
mRNA 21371465
C058956 3458 IFNG
IFG
IFI
interferon, gamma acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 3458 IFNG
IFG
IFI
interferon, gamma acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 3458 IFNG
IFG
IFI
interferon, gamma acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 3458 IFNG
IFG
IFI
interferon, gamma acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 3458 IFNG
IFG
IFI
interferon, gamma acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
C058956 3458 IFNG
IFG
IFI
interferon, gamma acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of IL8 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
C058956 3458 IFNG
IFG
IFI
interferon, gamma acteoside results in decreased expression of IFNG mRNA decreases expression
mRNA 21371465
C058956 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] decreases reaction
/ increases expression
mRNA 21756928
C058956 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) acteoside results in decreased expression of IL6 mRNA decreases expression
mRNA 21756928
C058956 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 [acteoside co-treated with TGFA protein] results in increased expression of IL8 mRNA affects cotreatment
/ increases expression
mRNA 21756928
C058956 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acteoside inhibits the reaction [leptomycin B results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 21967610
C058956 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 21756928
C058956 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of IL8 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
C058956 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acteoside results in decreased expression of IL8 mRNA decreases expression
mRNA 21371465
21756928
C058956 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acteoside results in decreased secretion of IL8 protein decreases secretion
protein 21756928
21967610
C058956 3689 ITGB2
CD18
LAD
LCAMB
LFA-1
MAC-1
MF17
MFI7
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein] decreases reaction
/ increases expression
protein 16393473
C058956 3689 ITGB2
CD18
LAD
LCAMB
LFA-1
MAC-1
MF17
MFI7
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] decreases reaction
/ increases expression
protein 16393473
C058956 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) acteoside results in decreased phosphorylation of MAPK1 protein decreases phosphorylation
protein 21756928
C058956 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) acteoside results in decreased phosphorylation of MAPK3 protein decreases phosphorylation
protein 21756928
C058956 27035 NOX1
GP91-2
MOX1
NOH-1
NOH1
NADPH oxidase 1 acteoside results in decreased activity of NOX1 protein decreases activity
protein 16393473
C058956 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA affects cotreatment
/ decreases expression
mRNA 21756928
C058956 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 acteoside results in decreased phosphorylation of RB1 protein decreases phosphorylation
protein 17634406
C058956 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] affects binding
/ decreases phosphorylation
/ increases reaction
protein 17634406
C058956 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] decreases reaction
/ increases phosphorylation
protein 21756928
C058956 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 4087 SMAD2
JV18
JV18-1
MADH2
MADR2
hMAD-2
hSMAD2
SMAD family member 2 acteoside results in increased phosphorylation of SMAD2 protein increases phosphorylation
protein 17634406
C058956 4088 SMAD3
HSPC193
HsT17436
JV15-2
LDS1C
LDS3
MADH3
SMAD family member 3 acteoside results in increased phosphorylation of SMAD3 protein increases phosphorylation
protein 17634406
C058956 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) acteoside results in decreased expression of SOD2 mRNA decreases expression
mRNA 21371465
C058956 7039 TGFA
TFGA
transforming growth factor, alpha [acteoside co-treated with TGFA protein] results in increased expression of IL8 mRNA affects cotreatment
/ increases expression
protein 21756928
C058956 7039 TGFA
TFGA
transforming growth factor, alpha acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] affects localization
/ increases reaction
protein 21967610
C058956 7039 TGFA
TFGA
transforming growth factor, alpha acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form] affects localization
/ increases reaction
protein 21967610
C058956 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 acteoside results in increased expression of TGFB1 mRNA increases expression
mRNA 17634406
C058956 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
C058956 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
C058956 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of IL8 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
C058956 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 acteoside results in decreased expression of VCAM1 mRNA decreases expression
mRNA 21371465

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM preferred title UniProt
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (1)

KEGG disease name UniProt
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D007249 C058956 Inflammation therapeutic
21967610
D007938 C058956 Leukemia therapeutic
20932957
D014947 C058956 Wounds and Injuries therapeutic
21967610