PCIDB

Forsythia spp.

Species

KNApSAcK Entry

Organism name Forsythia spp.
Genus Forsythia
Family Oleaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Forsythia
Linked NCBI taxonomy ID 55182
Linked level genus

Family

Family in NCBI taxonomy Oleaceae
ID 4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002783 External link 512 Kusaginin
/ Acteoside
/ Verbascoside
CHEMBL231853
CHEMBL444478
CHEMBL1364101
C058956
12 / 1 / 1 34 / 3 No. 33
C00003780 External link 512 Neoxanthin
/ Folioxanthin
C011947
4 / 0 No. 114 No. 59
C00001136 External link 512 Lactose
CHEMBL417016
CHEMBL469865
CHEMBL470274
CHEMBL1254686
CHEMBL1903530
CHEMBL1908365
6 / 0 / 1 No. 423 No. 73
C00003779 External link 512 Mutatochrome
/ beta-carotene 5,8-epoxide
C001792
No. 1206 No. 59
C00003767 External link 512 5,6-epoxy-beta-Carotene
/ beta-Carotene 5,6-epoxide
C073147
No. 1206 No. 59

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002783 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002783 1 / 1
P17252 Protein kinase C alpha type Alpha C00002783 0 / 0
P47929 Galectin-7 Unclassified protein C00001136 0 / 0
P09382 Galectin-1 Other cytosolic protein C00001136 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002783 0 / 0
O00214 Galectin-8 Unclassified protein C00001136 0 / 0
O75496 Geminin Unclassified protein C00002783 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002783 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002783 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002783 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002783 0 / 0
Q6P4F1 Alpha-(1,3)-fucosyltransferase 10 Enzyme C00001136 0 / 0
P17931 Galectin-3 Other cytosolic protein C00001136 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00002783 0 / 0
O00182 Galectin-9 Unclassified protein C00001136 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002783 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002783 0 / 0

38 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00003780
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003780
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00003780
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00003780
196 AHR, bHLHe76 aryl hydrocarbon receptor C00002783
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00002783
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002783
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002783
894 CCND2, KIAK0002 cyclin D2 C00002783
896 CCND3 cyclin D3 C00002783
898 CCNE1, CCNE cyclin E1 C00002783
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00002783
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00002783
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00002783
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002783
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002783
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00002783
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002783
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00002783
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00002783
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002783
3458 IFNG, IFG, IFI interferon, gamma C00002783
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002783
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002783
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00002783
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002783
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002783
27035 NOX1, GP91-2, MOX1, NOH-1, NOH1 NADPH oxidase 1 C00002783
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002783
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002783
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002783
4087 SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 SMAD family member 2 C00002783
4088 SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 SMAD family member 3 C00002783
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00002783
7039 TGFA, TFGA transforming growth factor, alpha C00002783
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00002783
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002783
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002783

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM preferred title UniProt
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (2)

KEGG name UniProt
H00032 Thyroid cancer P17931 (marker)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007249 Inflammation C00002783
D007938 Leukemia C00002783
D014947 Wounds and Injuries C00002783