Fraxinus oxycarba

• Index
• Plant Species
• Metabolite list (13)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Fraxinus oxycarba
Genus	Fraxinus
Family	Oleaceae
Kingdom	Plantae

---

NCBI taxonomy

Entry

Linked NCBI taxonomy name	Fraxinus
Linked NCBI taxonomy ID	38871
Linked level	genus

Family

Family in NCBI taxonomy	Oleaceae
ID	4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (13)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005413	Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989	D012431	25 / 18 / 16	29 / 8	No. 1	No. 15
C00005169	Nicotiflorin / Nicotifloroside / Kaempferol 3-O-rutinoside / Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside / (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside	CHEMBL431610 CHEMBL79790 CHEMBL255020 CHEMBL501550 CHEMBL498879 CHEMBL1419228 CHEMBL1875691		22 / 10 / 12		No. 1	No. 15
C00005138	Astragalin / Kaempferol 3-glucoside / Kaempferol 3-O-beta-D-glucoside / Kaempferol 3-O-beta-D-glucopyranoside	CHEMBL233930 CHEMBL453290 CHEMBL1572115	C001579	10 / 6 / 7	0 / 1	No. 2	No. 15
C00034404	Aceoside	CHEMBL449185				No. 17	No. 11
C00002783	Kusaginin / Acteoside / Verbascoside	CHEMBL231853 CHEMBL444478 CHEMBL1364101	C058956	12 / 1 / 1	34 / 3	No. 33
C00037421	Ligstroside / (-)-Ligstroside	CHEMBL1086877		1 / 1 / 0		No. 243
C00049064	10-Hydroxyligstroside / (-)-10-Hydroxyligstroside					No. 243
C00003093	Oleuropein	CHEMBL1911053	C002769		8 / 5	No. 243
C00010786	10-Hydroxyoleuropein					No. 243
C00007191	(+)-8(1)-Hydroxypinoresinol	CHEMBL471274				No. 700	No. 21
C00049162	Fraxicarboside B					No. 842
C00049161	Fraxicarboside A					No. 842
C00049163	Fraxicarboside C					No. 842

Human Protein / Gene in interactions

47 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9UBT6	DNA polymerase kappa	Enzyme	C00002783 C00005169 C00005413	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002783 C00005138 C00005169	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002783 C00005138 C00005169	1 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00005138 C00005169 C00005413	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00005138 C00005413	4 / 2
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00005169 C00005413	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002783 C00005413	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00005138 C00005169	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00005169 C00005413	1 / 1
P06746	DNA polymerase beta	Enzyme	C00005169 C00005413	0 / 0
P07237	Protein disulfide-isomerase	Enzyme	C00005138 C00005169	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00005169 C00005413	1 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002783 C00005169	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002783 C00005169	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00002783 C00005169	0 / 0
O75496	Geminin	Unclassified protein	C00002783 C00005169	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002783 C00005169	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002783 C00005169	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00005138 C00005169	1 / 1
P33527	Multidrug resistance-associated protein 1	drugs	C00005413	0 / 0
P15121	Aldose reductase	Enzyme	C00005138	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002783	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00005413	0 / 0
P27487	Dipeptidyl peptidase 4	S9B	C00005413	0 / 1
P06276	Cholinesterase	Hydrolase	C00005413	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00005413	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00005413	3 / 3
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00005413	2 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00005138	0 / 0
P03372	Estrogen receptor	NR3A1	C00005413	1 / 1
P22303	Acetylcholinesterase	Hydrolase	C00005413	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00005413	0 / 1
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00005169	2 / 3
P11388	DNA topoisomerase 2-alpha	Isomerase	C00005413	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00005413	4 / 3
P14672	Solute carrier family 2, facilitated glucose transporter member 4	Unclassified protein	C00037421	1 / 0
P48147	Prolyl endopeptidase	S9A	C00005413	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00005413	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00005169	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00002783	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00005169	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00005169	1 / 4
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00005413	0 / 3
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00005138	0 / 3
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00005169	2 / 1

51 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002783 C00003093 C00005413
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002783 C00003093 C00005413
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002783 C00003093 C00005413
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002783 C00005413
7039	TGFA, TFGA	transforming growth factor, alpha	C00002783 C00005413
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002783 C00005413
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002783 C00003093
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00002783 C00003093
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002783 C00005413
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00002783 C00005413
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002783 C00005413
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002783 C00005413
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002783 C00005413
3458	IFNG, IFG, IFI	interferon, gamma	C00002783 C00005413
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002783 C00005413
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002783 C00005413
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00002783 C00005413
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003093
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002783
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002783
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002783
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00002783
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00002783
898	CCNE1, CCNE	cyclin E1	C00002783
896	CCND3	cyclin D3	C00002783
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00002783
894	CCND2, KIAK0002	cyclin D2	C00002783
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00002783
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002783
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00003093
27035	NOX1, GP91-2, MOX1, NOH-1, NOH1	NADPH oxidase 1	C00002783
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002783
4087	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2	SMAD family member 2	C00002783
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00002783
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002783
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00003093
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00002783
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00005413
581	BAX, BCL2L4	BCL2-associated X protein	C00005413
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00005413
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00005413
847	CAT	catalase (EC:1.11.1.6)	C00005413
873	CBR1, CBR, SDR21C1, hCBR1	carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)	C00005413
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00005413
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00005413
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00005413
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00005413
3667	IRS1, HIRS-1	insulin receptor substrate 1	C00005413
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00005413
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00005413
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions