KCF-S cluster No. 17 (160 metabolites)

Corresponding Phytochemical cluster No. 11

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (160)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Liliopsida	125
asterids	100
rosids	10
eudicotyledons	5
Euphyllophyta	1
Magnoliophyta	1

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Cumulative family count (Top 20)

class name	count
Solanaceae	89
Dioscoreaceae	50
Asparagaceae	37
Arecaceae	9
Apocynaceae	8
Amaryllidaceae	7
Fabaceae	6
Costaceae	5
Smilacaceae	5
Zygophyllaceae	4
Melanthiaceae	4
Liliaceae	3
Ruscaceae	3
Amaranthaceae	3
Ranunculaceae	2
Hyacinthaceae	1
Lamiaceae	1
Plantaginaceae	1
Magnoliaceae	1
Xanthorrhoeaceae	1

KEGG BRITE br08003

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Categories (4)

br08003 Category	# of metabolite
Steroid alkaloids	4
Spirostan	4
Furostan	2
Cholestane	1

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metabolites link (12)

br08003 Category	KEGG ID	KNApSAcK ID
Steroid alkaloids	C10796	C00002242
Steroid alkaloids	C10819	C00002260
Steroid alkaloids	C10820	C00002262
Steroid alkaloids	C10824	C00002265
Spirostan	C08894	C00003571
Spirostan	C08897	C00003575
Furostan	C08901	C00003579
Furostan	C08904	C00003582
Cholestane	C08905	C00003583
Spirostan	C08912	C00003591
Spirostan	C08919	C00003598
Spirostan	C08912	C00034244

Metabolite list (160)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002242	alpha-Chaconine		C011860
C00002260	Solamargine	CHEMBL443114 CHEMBL2005327
C00002262	alpha-Solanine	CHEMBL1212997 CHEMBL1392894 CHEMBL1975187 CHEMBL2357167	D012992	13 / 10 / 12
C00002265	Solasonine	CHEMBL438956 CHEMBL1967295
C00003571	Deltonin	CHEMBL502154 CHEMBL1964918 CHEMBL2207416	C016347
C00003575	Dioscin	CHEMBL507001 CHEMBL2036081 CHEMBL2036082	C019357		0 / 2
C00003579	Gracillin	CHEMBL500045 CHEMBL1965564	C044934
C00003582	Officinalisnin I	CHEMBL454275 CHEMBL1958309
C00003583	Osladin		C103830
C00003591	Asparinin B / Shatavarin IV / (+)-Asparinin B
C00003598	Yamogenin 3-O-neohesperidoside	CHEMBL395415 CHEMBL259202 CHEMBL554848 CHEMBL1994781 CHEMBL2036075 CHEMBL2036080
C00019213	Torvoside A
C00019214	Torvoside H
C00024131	Chinenoside III
C00024133	Chinenoside V
C00027720	21-Hydroxysycophantine
C00027797	Abutiloside A
C00027798	Abutiloside C
C00027860	Anguivine / (-)-Anguivine
C00028293	gamma-Tomatine
C00028333	Hapepunine 3-O-beta-cellobioside
C00028393	Isoanguivine
C00028685	N-Hydroxyrobustine
C00029026	Solanelagnin
C00029027	Solanidine 3-O-[alpha-L-rhamnopyranosyl-(1->2)[beta-D-glucopyranosyl-(1->4)]-beta-D-glucopyranoside
C00029067	Sycophantine
C00029249	Yibeinoside C
C00029313	(25S)-Kingianoside C
C00029745	Asparagoside E
C00029747	Asparoside B / Asparagusin A
C00029838	Borassoside A / (-)-Borassoside A
C00029839	Borassoside B / (-)-Borassoside B / 25-epi-Borassoside C
C00029840	Borassoside C / (-)-Borassoside C
C00029841	Borassoside D / (-)-Borassoside D	CHEMBL395647 CHEMBL2036079
C00029842	Borassoside E / 2'-O-Rhamnosylborassoside D	CHEMBL507001 CHEMBL2036081 CHEMBL2036082
C00029843	Borassoside F / (-)-Borassoside F	CHEMBL394043 CHEMBL503436 CHEMBL2004307
C00029922	Cesdiurin I / (-)-Cesdiurin I
C00029923	Cesdiurin II / (-)-Cesdiurin II
C00029924	Cesdiurin III
C00030069	Curillin G / (-)-Curillin G	CHEMBL86300 CHEMBL87450 CHEMBL1078617 CHEMBL1996816
C00030140	Progenin III / (-)-Progenin III / Diosgenin 3-O-alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranoside	CHEMBL395415 CHEMBL259202 CHEMBL554848 CHEMBL1994781 CHEMBL2036075 CHEMBL2036080
C00030142	Diospolysaponin A / (-)-Diospolysaponin A
C00030163	Dumoside
C00030412	Glycoside D / Protobioside	CHEMBL1159453
C00030617	Kingianoside C
C00030618	Kingianoside D
C00030763	Methyl protobioside / (-)-Methyl protobioside
C00030930	Parrisaponin		C067584		0 / 2
C00031080	Pregnadienolone-3-O-beta-D-chacotrioside	CHEMBL504581
C00031081	Pregnadienolone-3-O-beta-D-gracillimatriose
C00031085	Progenin II	CHEMBL395647 CHEMBL2036079
C00031088	Protobioside	CHEMBL1159453
C00031415	Torvoside J	CHEMBL453475 CHEMBL502467
C00031416	Torvoside K / (-)-Torvoside K	CHEMBL453475 CHEMBL502467
C00031417	Torvoside L	CHEMBL453475 CHEMBL502467
C00031568	Agamenoside H
C00032096	Orbiculatoside B / (-)-Orbiculatoside B	CHEMBL450855
C00032169	Solasodoside A / (-)-Solasodoside A
C00032184	Spiroconazole A
C00032191	Spongipregnoloside C / (-)-Spongipregnoloside C
C00032192	Spongipregnoloside D / (-)-Spongipregnoloside D
C00032360	Timosaponin BII	CHEMBL454275 CHEMBL1958309
C00032508	Wattoside I / (-)-Wattoside I
C00032538	Yamogenin 3-O-alpha-L-rhamnopyranosyl(1->4)-alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranoside	CHEMBL507001 CHEMBL2036081 CHEMBL2036082
C00032539	Yamogenin 3-O-alpha-L-rhamnopyranosyl(1->4)-beta-D-glucopyranoside	CHEMBL395647 CHEMBL2036079
C00032679	Abutiloside B
C00032682	Abutiloside F / (-)-Abutiloside F
C00032683	Abutiloside G / (-)-Abutiloside G
C00032684	Abutiloside H
C00032685	Abutiloside I / (-)-Abutiloside I
C00032686	Abutiloside J / (-)-Abutiloside J
C00032687	Abutiloside K / (-)-Abutiloside K
C00032707	Anguivioside A / (-)-Anguivioside A
C00032708	Anguivioside B / (-)-Anguivioside B
C00032709	Anguivioside C
C00033016	Hemeroside A / (-)-Hemeroside A
C00033440	Trigoneoside Xa
C00033441	Trigoneoside Xb / (-)-Trigoneoside Xb
C00033442	Trigoneoside XIb / (-)-Trigoneoside XIb
C00033443	Trigoneoside XIIa / (-)-Trigoneoside XIIa
C00033444	Trigoneoside XIIb / (-)-Trigoneoside XIIb
C00033524	12-Hydroxysolasonine
C00033702	Caucasicoside B / (-)-Caucasicoside B
C00033703	Caucasicoside C / (-)-Caucasicoside C
C00033778	Dioseptemloside A / (-)-Dioseptemloside A
C00033780	Dioseptemloside C / (-)-Dioseptemloside C
C00033781	Dioseptemloside D / (-)-Dioseptemloside D
C00033782	Dioseptemloside E / (-)-Dioseptemloside E
C00033783	Dioseptemloside F / (-)-Dioseptemloside F
C00033784	Dioseptemloside G / (-)-Dioseptemloside G
C00033785	Dioseptemloside H / (-)-Dioseptemloside H
C00033806	Elephanoside A / (-)-Elephanoside A
C00033809	Elephanoside D / (+)-Elephanoside D
C00033810	Elephanoside E / (-)-Elephanoside E
C00033951	Immunoside / (-)-Immunoside	CHEMBL438511 CHEMBL2036076 CHEMBL2049186
C00034031	Lobofrutoside
C00034038	Lyconoside Ia / (-)-Lyconoside Ia
C00034039	Lyconoside Ib / (-)-Lyconoside Ib
C00034040	Lyconoside II / (-)-Lyconoside II
C00034041	Lyconoside III / (-)-Lyconoside III
C00034042	Lyconoside IV / (-)-Lyconoside IV
C00034174	Prototribestin
C00034202	Robeneoside A / (-)-Robeneoside A
C00034203	Robeneoside B / (-)-Robeneoside B
C00034218	Asparanin A / (-)-Asparanin A / Schidigera saponin D5
C00034242	Shatavarin IX / (-)-Shatavarin IX
C00034243	Shatavarin V / (+)-Shatavarin V	CHEMBL469461
C00034244	Shatavarin VI / (-)-Shatavarin VI
C00034245	Shatavarin VII / (-)-Shatavarin VII
C00034247	Shatavarin X / (-)-Shatavarin X
C00034329	Tribestin
C00034404	Aceoside	CHEMBL449185
C00034454	beta-Chaconine		C045745
C00034457	beta-Solanine
C00034733	Turrillianoside
C00035155	Racemoside B / (-)-Racemoside B
C00035156	Racemoside C / (-)-Racemoside C
C00035866	Pentandroside E / (+)-Pentandroside E
C00036028	Abutiloside O / (-)-Abutiloside O
C00036802	beta-Solamarine	CHEMBL443114 CHEMBL2005327	C026609		11 / 0
C00037833	Solaculine A / (-)-Solaculine A
C00037976	Urginin
C00038010	Volubiloside A
C00038011	Volubiloside B / (-)-Volubiloside B
C00038012	Volubiloside C / (+)-Volubiloside C
C00040570	Tuberoside A(Allium)
C00041031	Lasianthoside A
C00041032	Lasianthoside B
C00041694	Neosibiricoside D	CHEMBL446998
C00042245	Aspaoligonin A / Sarsasapogenin M / (-)-Aspaoligonin A	CHEMBL466365
C00042246	Aspaoligonin B	CHEMBL504136
C00042477	Disporoside A / (-)-Disporoside A	CHEMBL505982
C00042692	Leptinine I
C00042693	Leptinine II
C00042934	Sansevierin A / (-)-Sansevierin A	CHEMBL505827
C00042935	Sansevistatin 1 / (-)-Sansevistatin 1	CHEMBL503505
C00042936	Sansevistatin 2 / (-)-Sansevistatin 2	CHEMBL503620 CHEMBL448194 CHEMBL505077
C00043831	Polygonatoside B	CHEMBL455222
C00043832	Polygonatoside C / (-)-Polygonatoside C
C00043833	Polygonatoside D	CHEMBL506879
C00044542	Ascaloniside A1	CHEMBL2349227
C00044543	Ascaloniside A2	CHEMBL2349227
C00045124	Triquetroside C1 / (-)-Triquetroside C1
C00045125	Triquetroside C2 / (-)-Triquetroside C2
C00045636	Anguivioside III / (-)-Anguivioside III
C00046183	Namonin C / (-)-Namonin C	CHEMBL499981
C00046184	Namonin D / (-)-Namonin D	CHEMBL504150
C00046882	Russelioside B / (-)-Russelioside B
C00046884	Russelioside D / (-)-Russelioside D
C00046943	Surculoside A / (-)-Surculoside A
C00046944	Surculoside B
C00046945	Surculoside C / (-)-Surculoside C
C00048333	Bethoside B / (-)-Bethoside B
C00048418	Hoodigoside Y / (-)-Hoodigoside Y
C00048504	Pennogenin 3-O-beta-chacotrioside / (-)-Pennogenin 3-O-beta-chacotrioside	CHEMBL501681
C00048513	Polygonatoside B3 / (-)-Polygonatoside B3	CHEMBL478738
C00049399	Solakhasoside / (-)-Solakhasoside
C00050277	Brodiosaponin A / (-)-Brodiosaponin A
C00050325	Aferoside B / (-)-Aferoside B	CHEMBL510683
C00050326	Aferoside C / (-)-Aferoside C	CHEMBL500494

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q16637	Survival motor neuron protein	Unclassified protein	C00002262	4 / 1
Q99700	Ataxin-2	Unclassified protein	C00002262	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002262	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00002262	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002262	2 / 0
O75496	Geminin	Unclassified protein	C00002262	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002262	0 / 0
Q99816	Tumor susceptibility gene 101 protein	Unclassified protein	C00002262	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002262	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002262	0 / 0
O00255	Menin	Unclassified protein	C00002262	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002262	1 / 2
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00002262	0 / 3

11 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
581	BAX, BCL2L4	BCL2-associated X protein	C00036802
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00036802
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00036802
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00036802
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00036802
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00036802
1508	CTSB, APPS, CPSB	cathepsin B (EC:3.4.22.1)	C00036802
8772	FADD, MORT1	Fas (TNFRSF6)-associated via death domain	C00036802
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00036802
7132	TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60	tumor necrosis factor receptor superfamily, member 1A	C00036802
8717	TRADD, Hs.89862	TNFRSF1A-associated via death domain	C00036802

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions