PCIDB

KNApSAcK Metabolite C00036802

Metabolite

KNApSAcK Entry

id C00036802
Name beta-Solamarine
CAS RN 3671-38-3
Standard InChI InChI=1S/C45H73NO15/c1-19-9-14-45(46-17-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(53)34(51)32(49)22(4)56-41)37(54)38(29(18-47)58-42)59-40-35(52)33(50)31(48)21(3)55-40/h7,19-22,24-42,46-54H,8-18H2,1-6H3/t19-,20-,21-,22-,24-,25+,26-,27-,28-,29+,30-,31-,32-,33+,34+,35+,36+,37-,38+,39+,40-,41-,42+,43-,44-,45-/m0/s1
Standard InChI (Main Layer) InChI=1S/C45H73NO15/c1-19-9-14-45(46-17-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(53)34(51)32(49)22(4)56-41)37(54)38(29(18-47)58-42)59-40-35(52)33(50)31(48)21(3)55-40/h7,19-22,24-42,46-54H,8-18H2,1-6H3

Cluster

Phytochemical cluster No. 11
KCF-S cluster No. 17

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL443114 CHEMBL2005327

KEGG

By LinkDB

CTD

By CAS RN C026609

Species

Summary

Plant class

class name count
asterids 2

Family

family name count
Solanaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Solanum aculeastrum Dunal 329759 Solanaceae asterids Viridiplantae
Solanum dulcamara L. 45834 Solanaceae asterids Viridiplantae

Human Protein / Gene in interaction

CTD interaction (17)

compound gene gene name gene description interaction interaction type form reference
pmid
C026609 581 BAX
BCL2L4
BCL2-associated X protein beta-solamarine promotes the reaction [Cisplatin results in increased expression of BAX protein] increases expression
/ increases reaction
protein 17619073
C026609 581 BAX
BCL2L4
BCL2-associated X protein beta-solamarine results in increased expression of BAX protein increases expression
protein 17619073
20647040
C026609 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 beta-solamarine results in decreased expression of BCL2 protein decreases expression
protein 17619073
20647040
C026609 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 beta-solamarine results in decreased expression of BCL2L1 protein decreases expression
protein 17619073
C026609 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 17619073
C026609 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) beta-solamarine results in increased activity of CASP3 protein increases activity
protein 17619073
C026609 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) beta-solamarine results in increased cleavage of CASP3 protein increases cleavage
protein 20647040
C026609 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP8 protein] increases activity
/ increases reaction
protein 17619073
C026609 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) beta-solamarine results in increased activity of CASP8 protein increases activity
protein 17619073
C026609 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP9 protein] increases activity
/ increases reaction
protein 17619073
C026609 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) beta-solamarine results in increased activity of CASP9 protein increases activity
protein 17619073
C026609 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) beta-solamarine results in increased cleavage of CASP9 protein increases cleavage
protein 20647040
C026609 1508 CTSB
APPS
CPSB
cathepsin B (EC:3.4.22.1) beta-solamarine affects the localization of CTSB protein affects localization
protein 20647040
C026609 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain beta-solamarine results in increased expression of FADD protein increases expression
protein 17619073
C026609 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor beta-solamarine results in increased expression of FAS protein increases expression
protein 17619073
C026609 7132 TNFRSF1A
CD120a
FPF
MS5
TBP1
TNF-R
TNF-R-I
TNF-R55
TNFAR
TNFR1
TNFR1-d2
TNFR55
TNFR60
p55
p55-R
p60
tumor necrosis factor receptor superfamily, member 1A beta-solamarine results in increased expression of TNFRSF1A protein increases expression
protein 17619073
C026609 8717 TRADD
Hs.89862
TNFRSF1A-associated via death domain beta-solamarine results in increased expression of TRADD protein increases expression
protein 17619073