Solanum dulcamara L.
Species
KNApSAcK Entry
| Organism name | Solanum dulcamara L. |
|---|---|
| Genus | Solanum |
| Family | Solanaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Solanum dulcamara |
|---|---|
| Linked NCBI taxonomy ID | 45834 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Solanaceae |
|---|---|
| ID | 4070 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (31)
| Species | Activity |
|---|---|
| Solanum dulcamara L. | Alterative |
| Solanum dulcamara L. | Analgesic |
| Solanum dulcamara L. | Anaphrodisiac |
| Solanum dulcamara L. | Anticholinergic |
| Solanum dulcamara L. | Antidote |
| Solanum dulcamara L. | Antiinflammatory |
| Solanum dulcamara L. | Antipyretic |
| Solanum dulcamara L. | Antisarcomic |
| Solanum dulcamara L. | Antiseptic |
| Solanum dulcamara L. | Antiviral |
| Solanum dulcamara L. | Astringent |
| Solanum dulcamara L. | Cardiotonic |
| Solanum dulcamara L. | Cytotoxic |
| Solanum dulcamara L. | Depurative |
| Solanum dulcamara L. | Diaphoretic |
| Solanum dulcamara L. | Diuretic |
| Solanum dulcamara L. | Emetic |
| Solanum dulcamara L. | Expectorant |
| Solanum dulcamara L. | Hypnotic |
| Solanum dulcamara L. | Immunostimulant |
| Solanum dulcamara L. | Laxative |
| Solanum dulcamara L. | Mucoirritant |
| Solanum dulcamara L. | Narcotic |
| Solanum dulcamara L. | Pectoral |
| Solanum dulcamara L. | Phagocytotic |
| Solanum dulcamara L. | Poison |
| Solanum dulcamara L. | Resolvent |
| Solanum dulcamara L. | Secretagogue |
| Solanum dulcamara L. | Sedative |
| Solanum dulcamara L. | Stimulant |
| Solanum dulcamara L. | Tonic |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00036802
|
beta-Solamarine
|
CHEMBL443114
CHEMBL2005327 |
C026609
|
11 / 0 | No. 17 | No. 11 |
|
|
|
C00029023
|
Soladulcidine
|
CHEMBL365417
CHEMBL1476096 CHEMBL1622974 CHEMBL1976775 CHEMBL1998601 CHEMBL2165711 |
10 / 15 / 14 | No. 171 | No. 11 |
|
||
|
C00002282
|
Calystegin A3
/ Calystegine A3 |
No. 643 | No. 1 |
|
||||
|
C00028001
|
Calystegine B1
|
CHEMBL1965915
|
C110567
|
No. 643 | No. 1 |
|
||
|
C00036863
|
Calystegine A5
|
No. 643 | No. 1 |
|
||||
|
C00036870
|
Calystegine N1
|
No. 643 | No. 1 |
|
Human Protein / Gene in interactions
10 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q15125 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Enzyme | C00029023 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00029023 | 1 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00029023 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00029023 | 11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00029023 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00029023 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00029023 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00029023 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00029023 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00029023 | 0 / 1 |
11 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00036802
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00036802
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00036802
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00036802
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00036802
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00036802
|
| 1508 | CTSB, APPS, CPSB | cathepsin B (EC:3.4.22.1) |
C00036802
|
| 8772 | FADD, MORT1 | Fas (TNFRSF6)-associated via death domain |
C00036802
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00036802
|
| 7132 | TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 | tumor necrosis factor receptor superfamily, member 1A |
C00036802
|
| 8717 | TRADD, Hs.89862 | TNFRSF1A-associated via death domain |
C00036802
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (15)
| OMIM | preferred title | UniProt |
|---|---|---|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #302960 | Chondrodysplasia punctata 2, x-linked dominant; cdpx2 |
Q15125
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (14)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H01194 | X-linked chondrodysplasia punctata |
Q15125
(related)
|