PCIDB

KNApSAcK Metabolite C00003093

Metabolite

KNApSAcK Entry

id C00003093
Name Oleuropein
CAS RN 32619-42-4
Standard InChI InChI=1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3/b13-3+/t14-,18?,20+,21-,22?,24-,25-/m0/s1
Standard InChI (Main Layer) InChI=1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 243

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL1911053

KEGG

By LinkDB C09794

CTD

By CAS RN C002769

Human Protein / Gene in interaction

CTD interaction (13)

compound gene gene name gene description interaction interaction type form reference
pmid
C002769 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) oleuropein results in decreased activity of CYP19A1 protein decreases activity
protein 17910019
C002769 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 12615669
C002769 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) oleuropein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
mRNA 22595400
C002769 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) oleuropein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein] decreases reaction
/ increases secretion
protein 22595400
C002769 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) oleuropein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 22595400
C002769 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) oleuropein inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] decreases reaction
/ increases chemical synthesis
/ increases expression
protein 22595400
C002769 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A oleuropein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased activity of RELA protein] decreases reaction
/ increases activity
/ increases localization
protein 22595400
C002769 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 12615669
C002769 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor oleuropein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12615669
C002769 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 12615669
C002769 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12615669
C002769 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 oleuropein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12615669
C002769 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 oleuropein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12615669

Related Disease

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D064420 C002769 Drug-Related Side Effects and Adverse Reactions therapeutic
17223128
D006331 C002769 Heart Diseases therapeutic
17223128
D006937 C002769 Hypercholesterolemia therapeutic
18823963
D006949 C002769 Hyperlipidemias therapeutic
18823963
D015228 C002769 Hypertriglyceridemia therapeutic
18823963