Species

KNApSAcK Entry

Organism name Fraxinus ornus
Genus Fraxinus
Family Oleaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Fraxinus ornus
Linked NCBI taxonomy ID 38874
Linked level species

Family

Family in NCBI taxonomy Oleaceae
ID 4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00037437 External link 512 Lugrandoside
/ (-)-Lugrandoside
No. 33
C00030516 External link 512 Isoacteoside
/ Isoverbascoside
CHEMBL504873
C064683
6 / 5 / 4 No. 33
C00003093 External link 512 Oleuropein
CHEMBL1911053
C002769
8 / 5 No. 243
C00037421 External link 512 Ligstroside
/ (-)-Ligstroside
CHEMBL1086877
1 / 1 / 0 No. 243
C00033686 External link 512 Calceolarioside B
CHEMBL518414
3 / 2 / 5 No. 382
C00040787 External link 512 2-(4-Hydroxyphenyl)-ethyl-(6-O-caffeoyl)-beta-D-glucopyranoside
No. 382
C00007191 External link 512 (+)-8(1)-Hydroxypinoresinol
CHEMBL471274
No. 700 No. 21
C00042518 External link 512 Framoside
No. 842
C00042597 External link 512 Hydroxyframoside B
No. 842
C00042596 External link 512 Hydroxyframoside A
No. 842
C00001150 External link 512 Stachyose
CHEMBL1625803
C005695
No. 1212
C00042598 External link 512 Hydroxyornoside
/ (-)-Hydroxyornoside
No. 4674

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00033686 0 / 3
P17252 Protein kinase C alpha type Alpha C00033686 0 / 0
P39900 Macrophage metalloelastase M10A C00030516 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00030516 2 / 2
P03956 Interstitial collagenase M10A C00030516 0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00033686 2 / 2
P45452 Collagenase 3 M10A C00030516 1 / 1
P08253 72 kDa type IV collagenase M10A C00030516 1 / 3
P14672 Solute carrier family 2, facilitated glucose transporter member 4 Unclassified protein C00037421 1 / 0
P08254 Stromelysin-1 M10A C00030516 1 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003093
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00003093
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00003093
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00003093
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00003093
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00003093
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00003093
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00003093

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#125853 Diabetes mellitus, noninsulin-dependent; niddm P14672
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452

KEGG DISEASE (8)

KEGG name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00017 Esophageal cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D064420 Drug-Related Side Effects and Adverse Reactions C00003093
D006331 Heart Diseases C00003093
D006937 Hypercholesterolemia C00003093
D006949 Hyperlipidemias C00003093
D015228 Hypertriglyceridemia C00003093